Stepwise conversion of the Cys6[4Fe–3S] to a Cys4[4Fe–4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase

The membrane-bound [NiFe]-hydrogenase of Cupriavidus necator is a rare example of a truly O2-tolerant hydrogenase. It catalyzes the oxidation of H2 into 2e− and 2H+ in the presence of high O2 concentrations. This characteristic trait is intimately linked to the unique Cys6[4Fe–3S] cluster located in...

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Veröffentlicht in:	Chemical science (Cambridge) 2023-09, Vol.14 (40), p.11105-11120
Hauptverfasser:	Schmidt, Andrea, Kalms, Jacqueline, Lorent, Christian, Katz, Sagie, Frielingsdorf, Stefan, Evans, Rhiannon M, Fritsch, Johannes, Siebert, Elisabeth, Teutloff, Christian, Armstrong, Fraser A, Zebger, Ingo, Lenz, Oliver, Scheerer, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Clusters Crystallography Electrons Enzymes Glycine Hydrogenase Intermetallic compounds Iron compounds Nickel compounds Oxidation
Online-Zugang:	Volltext
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