Evaluating the potential of semi-continuous itaconic acid fermentation by Aspergillus terreus: operational profile and experiences
Itaconic acid is an important bio-based chemical. The present study aims to evaluate the applicability of semi-continuous fermentation technique for itaconic acid production by Aspergillus terreus. The fermentation is planned to be connected with bipolar membrane electrodialysis unit for acid recove...
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| Veröffentlicht in: | World journal of microbiology & biotechnology 2023-12, Vol.39 (12), p.346-346, Article 346 |
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| creator | Hülber-Beyer, Éva Bélafi-Bakó, Katalin Rózsenberszki, Tamás Komáromy, Péter Nemestóthy, Nándor |
| description | Itaconic acid is an important bio-based chemical. The present study aims to evaluate the applicability of semi-continuous fermentation technique for itaconic acid production by
Aspergillus terreus.
The fermentation is planned to be connected with bipolar membrane electrodialysis unit for acid recovery. This process allows the reuse of residual glucose from the effluent. Our particular attention was focused on the effect of glucose concentration. Two different glucose supplementation strategies were tested: constant glucose concentration in the refilling medium and adjusted glucose concentration in order to maintain a continuously high – 120 g/L – glucose concentration in the fermentor. The itaconic acid titre, yield and productivity for the 24 h time periods between draining/refilling interventions were investigated. The constantly high glucose concentration in the fermentor resulted in doubled biomass formation. The average itaconic acid titre was 32.9 ± 2.7 g/L. The producing strain formed numerous spores during semi-continuous fermentation that germinated continuously. Yield and volumetric productivity showed a periodic pattern during the procedure. |
| doi_str_mv | 10.1007/s11274-023-03797-9 |
| format | Article |
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Aspergillus terreus.
The fermentation is planned to be connected with bipolar membrane electrodialysis unit for acid recovery. This process allows the reuse of residual glucose from the effluent. Our particular attention was focused on the effect of glucose concentration. Two different glucose supplementation strategies were tested: constant glucose concentration in the refilling medium and adjusted glucose concentration in order to maintain a continuously high – 120 g/L – glucose concentration in the fermentor. The itaconic acid titre, yield and productivity for the 24 h time periods between draining/refilling interventions were investigated. The constantly high glucose concentration in the fermentor resulted in doubled biomass formation. The average itaconic acid titre was 32.9 ± 2.7 g/L. The producing strain formed numerous spores during semi-continuous fermentation that germinated continuously. Yield and volumetric productivity showed a periodic pattern during the procedure.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>37843644</pmid><doi>10.1007/s11274-023-03797-9</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0799-7128</orcidid><orcidid>https://orcid.org/0000-0002-9052-4507</orcidid><orcidid>https://orcid.org/0000-0003-4702-5857</orcidid><orcidid>https://orcid.org/0000-0002-4203-0449</orcidid><orcidid>https://orcid.org/0000-0001-6983-5223</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of microbiology & biotechnology, 2023-12, Vol.39 (12), p.346-346, Article 346 |
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| subjects | Acid production Acids Applied Microbiology Aspergillus terreus Biochemistry Biomedical and Life Sciences Biotechnology Electrodialysis Environmental Engineering/Biotechnology Fermentation Glucose Itaconic acid Life Sciences Microbiology Productivity Refilling Spores |
| title | Evaluating the potential of semi-continuous itaconic acid fermentation by Aspergillus terreus: operational profile and experiences |
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