Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia
the management of septic metaphyseal nonunions is challenging, with inconsistent outcomes. Antibiotic cement-coated implants have been demonstrated good outcome for diaphyseal infected nonunions, however there is no data in metaphyseal infected nonunions. fifteen adult patients with septic metaphyse...
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| Veröffentlicht in: | Revista do Colegio Brasileiro de Cirurgioes 2022, Vol.49, p.e20223060 |
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| container_title | Revista do Colegio Brasileiro de Cirurgioes |
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| creator | Bidolegui, Fernando Codesido, Mariano Pereira, Sebastián Abraham, Agustín Pires, Robinson Esteves Giordano, Vincenzo |
| description | the management of septic metaphyseal nonunions is challenging, with inconsistent outcomes. Antibiotic cement-coated implants have been demonstrated good outcome for diaphyseal infected nonunions, however there is no data in metaphyseal infected nonunions.
fifteen adult patients with septic metaphyseal nonunions of the femur or tibia were treated with antibiotic cement-coated plates. The antibiotic cement-coated plate was prepared with either gentamicin or vancomycin. Outcome measures were infection control, bone healing, return to pre-injury level on daily activities, and quality of life at the last follow-up visit. A p value of |
| doi_str_mv | 10.1590/0100-6991e-20223060-en |
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fifteen adult patients with septic metaphyseal nonunions of the femur or tibia were treated with antibiotic cement-coated plates. The antibiotic cement-coated plate was prepared with either gentamicin or vancomycin. Outcome measures were infection control, bone healing, return to pre-injury level on daily activities, and quality of life at the last follow-up visit. A p value of <5% was considered significant.
Methicillin-susceptible S. aureus was isolated in 53.3% cases. Average postoperative follow-up time was 18 months. Local infection control and radiographic bone healing were adequately achieved in 93.3% patients. No patient presented recurrent symptoms of surgical site infection. Fourteen patients reported to be either able, or on the same level as before injury, with 73.3% reporting no problems in all five dimensions of the EQ-5D-3L. Persistent infection was the only variable associated with a reduced long-term quality of life.
antibiotic cement-coated plate is a viable and efficient surgical technique for the definitive management of juxta-articular metaphyseal septic nonunions of the femur and tibia.</description><identifier>ISSN: 0100-6991</identifier><identifier>EISSN: 1809-4546</identifier><identifier>DOI: 10.1590/0100-6991e-20223060-en</identifier><identifier>PMID: 36629717</identifier><language>eng ; por</language><publisher>Brazil: Colégio Brasileiro de Cirurgiões</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Bone Cements - therapeutic use ; Femur - surgery ; Fractures, Ununited - surgery ; Humans ; Original ; Quality of Life ; Staphylococcus aureus ; Tibia - surgery ; Treatment Outcome</subject><ispartof>Revista do Colegio Brasileiro de Cirurgioes, 2022, Vol.49, p.e20223060</ispartof><rights>2022 Revista do Colégio Brasileiro de Cirurgiões 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c316n-c0a56c4ecbe9bdb8262a0d9b6ed855c163bf0006ef519a0387584a1d9fe11ce73</cites><orcidid>0000-0001-8322-7072 ; 0000-0002-3572-5576 ; 0000-0002-0502-2300 ; 0000-0001-9475-3158 ; 0000-0002-2280-1816 ; 0000-0002-4429-312X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578849/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578849/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36629717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bidolegui, Fernando</creatorcontrib><creatorcontrib>Codesido, Mariano</creatorcontrib><creatorcontrib>Pereira, Sebastián</creatorcontrib><creatorcontrib>Abraham, Agustín</creatorcontrib><creatorcontrib>Pires, Robinson Esteves</creatorcontrib><creatorcontrib>Giordano, Vincenzo</creatorcontrib><title>Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia</title><title>Revista do Colegio Brasileiro de Cirurgioes</title><addtitle>Rev Col Bras Cir</addtitle><description>the management of septic metaphyseal nonunions is challenging, with inconsistent outcomes. Antibiotic cement-coated implants have been demonstrated good outcome for diaphyseal infected nonunions, however there is no data in metaphyseal infected nonunions.
fifteen adult patients with septic metaphyseal nonunions of the femur or tibia were treated with antibiotic cement-coated plates. The antibiotic cement-coated plate was prepared with either gentamicin or vancomycin. Outcome measures were infection control, bone healing, return to pre-injury level on daily activities, and quality of life at the last follow-up visit. A p value of <5% was considered significant.
Methicillin-susceptible S. aureus was isolated in 53.3% cases. Average postoperative follow-up time was 18 months. Local infection control and radiographic bone healing were adequately achieved in 93.3% patients. No patient presented recurrent symptoms of surgical site infection. Fourteen patients reported to be either able, or on the same level as before injury, with 73.3% reporting no problems in all five dimensions of the EQ-5D-3L. Persistent infection was the only variable associated with a reduced long-term quality of life.
antibiotic cement-coated plate is a viable and efficient surgical technique for the definitive management of juxta-articular metaphyseal septic nonunions of the femur and tibia.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bone Cements - therapeutic use</subject><subject>Femur - surgery</subject><subject>Fractures, Ununited - surgery</subject><subject>Humans</subject><subject>Original</subject><subject>Quality of Life</subject><subject>Staphylococcus aureus</subject><subject>Tibia - surgery</subject><subject>Treatment Outcome</subject><issn>0100-6991</issn><issn>1809-4546</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtu2zAQhomgQew8rhDwAmqGokSJq8Iw2qRAgGzaNTGihjEDiVRF2UBO0utWcmqjXf2L-R8DfIzdC_gsSg0PIAAypbWgLIc8l6Ago3DB1qIGnRVloT6x9dm0YtcpvQEUUmh5xVZSqVxXolqz35sw-cbHyVtuqacwZTbiRC0fulm4Txz5wWPTEcfQcnLOWz_b-ER2F_yvPXEXRz7tiLfkfPCTPxDvMeDrsY5Hx3uacNi9J8KOJxqWrRDDPvgY0nJfwo76_XicWP7BW3bpsEt091dv2M9vX39sn7Lnl8fv281zZqVQIbOApbIF2YZ00zZ1rnKEVjeK2rosrVCycQCgyJVCI8i6KusCRasdCWGpkjfsy0fvsG96au388YidGUbf4_huInrz_yX4nXmNByOgrOq60HOD-miwY0xpJHcOCzALK7NgMEdW5sTKUJiD9_9On2MnOPIPD7aV4w</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Bidolegui, Fernando</creator><creator>Codesido, Mariano</creator><creator>Pereira, Sebastián</creator><creator>Abraham, Agustín</creator><creator>Pires, Robinson Esteves</creator><creator>Giordano, Vincenzo</creator><general>Colégio Brasileiro de Cirurgiões</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8322-7072</orcidid><orcidid>https://orcid.org/0000-0002-3572-5576</orcidid><orcidid>https://orcid.org/0000-0002-0502-2300</orcidid><orcidid>https://orcid.org/0000-0001-9475-3158</orcidid><orcidid>https://orcid.org/0000-0002-2280-1816</orcidid><orcidid>https://orcid.org/0000-0002-4429-312X</orcidid></search><sort><creationdate>2022</creationdate><title>Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia</title><author>Bidolegui, Fernando ; Codesido, Mariano ; Pereira, Sebastián ; Abraham, Agustín ; Pires, Robinson Esteves ; Giordano, Vincenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316n-c0a56c4ecbe9bdb8262a0d9b6ed855c163bf0006ef519a0387584a1d9fe11ce73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bone Cements - therapeutic use</topic><topic>Femur - surgery</topic><topic>Fractures, Ununited - surgery</topic><topic>Humans</topic><topic>Original</topic><topic>Quality of Life</topic><topic>Staphylococcus aureus</topic><topic>Tibia - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bidolegui, Fernando</creatorcontrib><creatorcontrib>Codesido, Mariano</creatorcontrib><creatorcontrib>Pereira, Sebastián</creatorcontrib><creatorcontrib>Abraham, Agustín</creatorcontrib><creatorcontrib>Pires, Robinson Esteves</creatorcontrib><creatorcontrib>Giordano, Vincenzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Revista do Colegio Brasileiro de Cirurgioes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bidolegui, Fernando</au><au>Codesido, Mariano</au><au>Pereira, Sebastián</au><au>Abraham, Agustín</au><au>Pires, Robinson Esteves</au><au>Giordano, Vincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia</atitle><jtitle>Revista do Colegio Brasileiro de Cirurgioes</jtitle><addtitle>Rev Col Bras Cir</addtitle><date>2022</date><risdate>2022</risdate><volume>49</volume><spage>e20223060</spage><pages>e20223060-</pages><issn>0100-6991</issn><eissn>1809-4546</eissn><abstract>the management of septic metaphyseal nonunions is challenging, with inconsistent outcomes. Antibiotic cement-coated implants have been demonstrated good outcome for diaphyseal infected nonunions, however there is no data in metaphyseal infected nonunions.
fifteen adult patients with septic metaphyseal nonunions of the femur or tibia were treated with antibiotic cement-coated plates. The antibiotic cement-coated plate was prepared with either gentamicin or vancomycin. Outcome measures were infection control, bone healing, return to pre-injury level on daily activities, and quality of life at the last follow-up visit. A p value of <5% was considered significant.
Methicillin-susceptible S. aureus was isolated in 53.3% cases. Average postoperative follow-up time was 18 months. Local infection control and radiographic bone healing were adequately achieved in 93.3% patients. No patient presented recurrent symptoms of surgical site infection. Fourteen patients reported to be either able, or on the same level as before injury, with 73.3% reporting no problems in all five dimensions of the EQ-5D-3L. Persistent infection was the only variable associated with a reduced long-term quality of life.
antibiotic cement-coated plate is a viable and efficient surgical technique for the definitive management of juxta-articular metaphyseal septic nonunions of the femur and tibia.</abstract><cop>Brazil</cop><pub>Colégio Brasileiro de Cirurgiões</pub><pmid>36629717</pmid><doi>10.1590/0100-6991e-20223060-en</doi><orcidid>https://orcid.org/0000-0001-8322-7072</orcidid><orcidid>https://orcid.org/0000-0002-3572-5576</orcidid><orcidid>https://orcid.org/0000-0002-0502-2300</orcidid><orcidid>https://orcid.org/0000-0001-9475-3158</orcidid><orcidid>https://orcid.org/0000-0002-2280-1816</orcidid><orcidid>https://orcid.org/0000-0002-4429-312X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Adult Anti-Bacterial Agents - therapeutic use Bone Cements - therapeutic use Femur - surgery Fractures, Ununited - surgery Humans Original Quality of Life Staphylococcus aureus Tibia - surgery Treatment Outcome |
| title | Antibiotic cement-coated plate is a viable and efficient technique for the definitive management of metaphyseal septic nonunions of the femur and tibia |
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