Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer
Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor invasion and metastasis. Recent efforts to understand EMT biology have uncovered that cells undergoing EMT attain a s...
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| Veröffentlicht in: | Oncogene 2023-07, Vol.42 (29), p.2237-2248 |
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| creator | Sample, Reilly A. Nogueira, Marina F. Mitra, Robi D. Puram, Sidharth V. |
| description | Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor invasion and metastasis. Recent efforts to understand EMT biology have uncovered that cells undergoing EMT attain a spectrum of intermediate “hybrid E/M” states, which exist along an epithelial-mesenchymal continuum. Here, we summarize recent studies characterizing the epigenetic drivers of hybrid E/M states. We focus on the histone-modification writers, erasers, and readers that assist or oppose the canonical hybrid E/M transcription factors that modulate hybrid E/M state transitions. We also examine the role of chromatin remodelers and DNA methylation in hybrid E/M states. Finally, we highlight the challenges of targeting hybrid E/M pharmacologically, and we propose future directions that might reveal the specific and targetable mechanisms by which hybrid E/M drives metastasis in patients. |
| doi_str_mv | 10.1038/s41388-023-02749-9 |
| format | Article |
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In cancer, EMT is thought to drive tumor invasion and metastasis. Recent efforts to understand EMT biology have uncovered that cells undergoing EMT attain a spectrum of intermediate “hybrid E/M” states, which exist along an epithelial-mesenchymal continuum. Here, we summarize recent studies characterizing the epigenetic drivers of hybrid E/M states. We focus on the histone-modification writers, erasers, and readers that assist or oppose the canonical hybrid E/M transcription factors that modulate hybrid E/M state transitions. We also examine the role of chromatin remodelers and DNA methylation in hybrid E/M states. Finally, we highlight the challenges of targeting hybrid E/M pharmacologically, and we propose future directions that might reveal the specific and targetable mechanisms by which hybrid E/M drives metastasis in patients.</description><subject>631/208/68</subject><subject>631/67/68</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell Biology</subject><subject>Chromatin</subject><subject>DNA methylation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Genes</subject><subject>Histones</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - pathology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Review Article</subject><subject>Transcription factors</subject><subject>Transcription Factors - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sample, Reilly A.</au><au>Nogueira, Marina F.</au><au>Mitra, Robi D.</au><au>Puram, Sidharth V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2023-07-14</date><risdate>2023</risdate><volume>42</volume><issue>29</issue><spage>2237</spage><epage>2248</epage><pages>2237-2248</pages><issn>0950-9232</issn><issn>1476-5594</issn><eissn>1476-5594</eissn><abstract>Epithelial-to-mesenchymal transition (EMT) is a process by which cells lose their epithelial characteristics and gain mesenchymal phenotypes. In cancer, EMT is thought to drive tumor invasion and metastasis. Recent efforts to understand EMT biology have uncovered that cells undergoing EMT attain a spectrum of intermediate “hybrid E/M” states, which exist along an epithelial-mesenchymal continuum. Here, we summarize recent studies characterizing the epigenetic drivers of hybrid E/M states. We focus on the histone-modification writers, erasers, and readers that assist or oppose the canonical hybrid E/M transcription factors that modulate hybrid E/M state transitions. We also examine the role of chromatin remodelers and DNA methylation in hybrid E/M states. Finally, we highlight the challenges of targeting hybrid E/M pharmacologically, and we propose future directions that might reveal the specific and targetable mechanisms by which hybrid E/M drives metastasis in patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37344626</pmid><doi>10.1038/s41388-023-02749-9</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3543-889X</orcidid><orcidid>https://orcid.org/0000-0001-5830-5083</orcidid></addata></record> |
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| subjects | 631/208/68 631/67/68 Apoptosis Cancer Cell adhesion & migration Cell Biology Chromatin DNA methylation Epigenesis, Genetic Epigenetics Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - genetics Genes Histones Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Metastases Metastasis Neoplasms - genetics Neoplasms - pathology Oncology Patients Phenotype Phenotypes Review Article Transcription factors Transcription Factors - genetics |
| title | Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer |
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