Diagnostic challenges of incidental lung lesions on liver MRI during the COVID-19 pandemic
The CT uncovered multiple ground glass opacities in a bilateral, multilobar and peripheral distribution, corresponding to the British Society of Thoracic Imaging classification of, classic/probable COVID-19 infection.3 Figure 2 shows the CT. The lack of sensitivity of RT-PCR and the poor specificity...
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description | The CT uncovered multiple ground glass opacities in a bilateral, multilobar and peripheral distribution, corresponding to the British Society of Thoracic Imaging classification of, classic/probable COVID-19 infection.3 Figure 2 shows the CT. The lack of sensitivity of RT-PCR and the poor specificity of thoracic CT, which are currently the two most commonly used diagnostic tests for COVID-19 infection, make it difficult to draw definite conclusions about suspicious lesions on MRI.4 5 At the time of writing this report, all published examples of pulmonary COVID-19 on MRI are descriptive.6–8 The limited available data primarily from thoracic MRI, however, suggest that on liver and abdominal imaging protocols, COVID-19 presents as lung lesions with: high T1 signal due to partial alveolar collapse and higher tissue density, high T2 signal caused by oedema or consolidation, high DWI signal because of increased cell density from the inflammatory reaction and partial collapse, and with a heterogeneous enhancement pattern after contrast administration. There is a need for more reliable diagnostic tests and better descriptors of COVID-19 infection on common abdominal MRI sequences so that the correct management decisions can be made when incidental lesions are detected such as in the case of the patient described here. |
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The lack of sensitivity of RT-PCR and the poor specificity of thoracic CT, which are currently the two most commonly used diagnostic tests for COVID-19 infection, make it difficult to draw definite conclusions about suspicious lesions on MRI.4 5 At the time of writing this report, all published examples of pulmonary COVID-19 on MRI are descriptive.6–8 The limited available data primarily from thoracic MRI, however, suggest that on liver and abdominal imaging protocols, COVID-19 presents as lung lesions with: high T1 signal due to partial alveolar collapse and higher tissue density, high T2 signal caused by oedema or consolidation, high DWI signal because of increased cell density from the inflammatory reaction and partial collapse, and with a heterogeneous enhancement pattern after contrast administration. There is a need for more reliable diagnostic tests and better descriptors of COVID-19 infection on common abdominal MRI sequences so that the correct management decisions can be made when incidental lesions are detected such as in the case of the patient described here.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2020-237430</identifier><identifier>PMID: 32690573</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Case reports ; Clinical Laboratory Techniques ; Coronavirus Infections - diagnosis ; Coronavirus Infections - diagnostic imaging ; Coronaviruses ; COVID-19 ; COVID-19 Testing ; Diffusion Magnetic Resonance Imaging ; Fatty Liver - complications ; Fatty Liver - diagnostic imaging ; Female ; Global health ; Hemangioma - complications ; Hemangioma - diagnostic imaging ; Humans ; Images In ; Incidental Findings ; infections ; infectious diseases ; Injuries ; Liver Neoplasms - complications ; Liver Neoplasms - diagnostic imaging ; Lung - diagnostic imaging ; Lungs ; Magnetic Resonance Imaging ; Medical diagnosis ; Middle Aged ; Neoplasms, Multiple Primary - complications ; Neoplasms, Multiple Primary - diagnostic imaging ; Pandemics ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - diagnostic imaging ; radiology (diagnostics) ; respiratory system ; Reverse Transcriptase Polymerase Chain Reaction ; Sensitivity and Specificity ; Tomography, X-Ray Computed</subject><ispartof>BMJ case reports, 2020-07, Vol.13 (7), p.e237430</ispartof><rights>BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. https://bmj.com/coronavirus/usage</rights><rights>BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b493t-e193a8c8c6e8084b85fafa85eea68fdfdba654fc3e8d309a12aaa07ac38363ef3</citedby><cites>FETCH-LOGICAL-b493t-e193a8c8c6e8084b85fafa85eea68fdfdba654fc3e8d309a12aaa07ac38363ef3</cites><orcidid>0000-0002-6206-7337</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577742/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577742/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32690573$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deen, Surrin Shazam</creatorcontrib><creatorcontrib>Wetscherek, Maria</creatorcontrib><creatorcontrib>Karia, Sumit</creatorcontrib><creatorcontrib>Godfrey, Edmund M</creatorcontrib><title>Diagnostic challenges of incidental lung lesions on liver MRI during the COVID-19 pandemic</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><addtitle>BMJ Case Rep</addtitle><description>The CT uncovered multiple ground glass opacities in a bilateral, multilobar and peripheral distribution, corresponding to the British Society of Thoracic Imaging classification of, classic/probable COVID-19 infection.3 Figure 2 shows the CT. The lack of sensitivity of RT-PCR and the poor specificity of thoracic CT, which are currently the two most commonly used diagnostic tests for COVID-19 infection, make it difficult to draw definite conclusions about suspicious lesions on MRI.4 5 At the time of writing this report, all published examples of pulmonary COVID-19 on MRI are descriptive.6–8 The limited available data primarily from thoracic MRI, however, suggest that on liver and abdominal imaging protocols, COVID-19 presents as lung lesions with: high T1 signal due to partial alveolar collapse and higher tissue density, high T2 signal caused by oedema or consolidation, high DWI signal because of increased cell density from the inflammatory reaction and partial collapse, and with a heterogeneous enhancement pattern after contrast administration. There is a need for more reliable diagnostic tests and better descriptors of COVID-19 infection on common abdominal MRI sequences so that the correct management decisions can be made when incidental lesions are detected such as in the case of the patient described here.</description><subject>Case reports</subject><subject>Clinical Laboratory Techniques</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - diagnostic imaging</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 Testing</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - diagnostic imaging</subject><subject>Female</subject><subject>Global health</subject><subject>Hemangioma - complications</subject><subject>Hemangioma - diagnostic imaging</subject><subject>Humans</subject><subject>Images In</subject><subject>Incidental Findings</subject><subject>infections</subject><subject>infectious diseases</subject><subject>Injuries</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Lung - diagnostic imaging</subject><subject>Lungs</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Neoplasms, Multiple Primary - complications</subject><subject>Neoplasms, Multiple Primary - diagnostic imaging</subject><subject>Pandemics</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - diagnostic imaging</subject><subject>radiology (diagnostics)</subject><subject>respiratory system</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkd1rFDEUxQdRbKl99k0CvogybT5mJpknka22C5WCqIgv4U7mzm6WTLImMwX_e1O2bluhYF4SOL8czr2nKF4yesKYaE47E0tOOS25kJWgT4pDJmtZypb-eHrvfVAcp7Sh-QhWqUo8Lw4Eb1paS3FY_DyzsPIhTdYQswbn0K8wkTAQ643t0U_giJv9ijhMNvgseeLsNUby-cuS9HO0WZvWSBZX35dnJWvJFnyPozUvimcDuITHt_dR8e3Tx6-Li_Ly6ny5-HBZdlUrphJZK0AZZRpUVFWdqgcYQNWI0KihH_oOmroajEDVC9oC4wBAJRihRCNwEEfF-53vdu5G7E3OHMHpbbQjxN86gNUPFW_XehWuNcsrkLLi2eHNrUMMv2ZMkx5tMugceAxz0rzitWorVouMvv4H3YQ5-jxfpoTgXNJGZup0R5kYUoo47NMwqm-607k7fdOd3nWXf7y6P8Se_9tUBt7ugG7c_Ifbuzt4H_Ax-g8I1a-6</recordid><startdate>20200720</startdate><enddate>20200720</enddate><creator>Deen, Surrin Shazam</creator><creator>Wetscherek, Maria</creator><creator>Karia, Sumit</creator><creator>Godfrey, Edmund M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6206-7337</orcidid></search><sort><creationdate>20200720</creationdate><title>Diagnostic challenges of incidental lung lesions on liver MRI during the COVID-19 pandemic</title><author>Deen, Surrin Shazam ; Wetscherek, Maria ; Karia, Sumit ; Godfrey, Edmund M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b493t-e193a8c8c6e8084b85fafa85eea68fdfdba654fc3e8d309a12aaa07ac38363ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Case reports</topic><topic>Clinical Laboratory Techniques</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - diagnostic imaging</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 Testing</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - diagnostic imaging</topic><topic>Female</topic><topic>Global health</topic><topic>Hemangioma - complications</topic><topic>Hemangioma - diagnostic imaging</topic><topic>Humans</topic><topic>Images In</topic><topic>Incidental Findings</topic><topic>infections</topic><topic>infectious diseases</topic><topic>Injuries</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Lung - diagnostic imaging</topic><topic>Lungs</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Neoplasms, Multiple Primary - complications</topic><topic>Neoplasms, Multiple Primary - diagnostic imaging</topic><topic>Pandemics</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - diagnostic imaging</topic><topic>radiology (diagnostics)</topic><topic>respiratory system</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deen, Surrin Shazam</creatorcontrib><creatorcontrib>Wetscherek, Maria</creatorcontrib><creatorcontrib>Karia, Sumit</creatorcontrib><creatorcontrib>Godfrey, Edmund M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deen, Surrin Shazam</au><au>Wetscherek, Maria</au><au>Karia, Sumit</au><au>Godfrey, Edmund M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic challenges of incidental lung lesions on liver MRI during the COVID-19 pandemic</atitle><jtitle>BMJ case reports</jtitle><stitle>BMJ Case Rep</stitle><addtitle>BMJ Case Rep</addtitle><date>2020-07-20</date><risdate>2020</risdate><volume>13</volume><issue>7</issue><spage>e237430</spage><pages>e237430-</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>The CT uncovered multiple ground glass opacities in a bilateral, multilobar and peripheral distribution, corresponding to the British Society of Thoracic Imaging classification of, classic/probable COVID-19 infection.3 Figure 2 shows the CT. The lack of sensitivity of RT-PCR and the poor specificity of thoracic CT, which are currently the two most commonly used diagnostic tests for COVID-19 infection, make it difficult to draw definite conclusions about suspicious lesions on MRI.4 5 At the time of writing this report, all published examples of pulmonary COVID-19 on MRI are descriptive.6–8 The limited available data primarily from thoracic MRI, however, suggest that on liver and abdominal imaging protocols, COVID-19 presents as lung lesions with: high T1 signal due to partial alveolar collapse and higher tissue density, high T2 signal caused by oedema or consolidation, high DWI signal because of increased cell density from the inflammatory reaction and partial collapse, and with a heterogeneous enhancement pattern after contrast administration. There is a need for more reliable diagnostic tests and better descriptors of COVID-19 infection on common abdominal MRI sequences so that the correct management decisions can be made when incidental lesions are detected such as in the case of the patient described here.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>32690573</pmid><doi>10.1136/bcr-2020-237430</doi><orcidid>https://orcid.org/0000-0002-6206-7337</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Case reports Clinical Laboratory Techniques Coronavirus Infections - diagnosis Coronavirus Infections - diagnostic imaging Coronaviruses COVID-19 COVID-19 Testing Diffusion Magnetic Resonance Imaging Fatty Liver - complications Fatty Liver - diagnostic imaging Female Global health Hemangioma - complications Hemangioma - diagnostic imaging Humans Images In Incidental Findings infections infectious diseases Injuries Liver Neoplasms - complications Liver Neoplasms - diagnostic imaging Lung - diagnostic imaging Lungs Magnetic Resonance Imaging Medical diagnosis Middle Aged Neoplasms, Multiple Primary - complications Neoplasms, Multiple Primary - diagnostic imaging Pandemics Pneumonia, Viral - diagnosis Pneumonia, Viral - diagnostic imaging radiology (diagnostics) respiratory system Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Tomography, X-Ray Computed |
title | Diagnostic challenges of incidental lung lesions on liver MRI during the COVID-19 pandemic |
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