Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects

The metabolic consequences of mitophagy alterations due to age-related stress in healthy aging brains versus neurodegeneration remain unknown. Here, we demonstrate that ceramide synthase 1 (CerS1) is transported to the outer mitochondrial membrane by the p17/PERMIT transporter that recognizes misloc...

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Veröffentlicht in:	Aging cell 2023-10, Vol.22 (10), p.e13954-e13954
Hauptverfasser:	Oleinik, Natalia, Albayram, Onder, Kassir, Mohamed Faisal, Atilgan, F Cansu, Walton, Chase, Karakaya, Eda, Kurtz, John, Alekseyenko, Alexander, Alsudani, Habeeb, Sheridan, Megan, Szulc, Zdzislaw M, Ogretmen, Besim
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer's disease Amyotrophic lateral sclerosis Animals Ceramide Ceramides - metabolism Cerebellum Cytochrome Dehydrogenases Endoplasmic reticulum Experiments Fumarates Glucose Localization Malates Metabolism Mice Mitochondria Mitochondrial DNA Mitophagy Motor Neurons - metabolism Neurodegeneration Parkinson's disease Proteins Quality control Ribonucleic acid Ribosomes RNA Selenium Sensorimotor system Sodium selenite Ubiquitin-Protein Ligases
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