Molecular basis of signal transduction mediated by the human GIPR splice variants

Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a potential drug target for metabolic disorders. It works with glucagon-like peptide-1 receptor and glucagon receptor in humans to maintain glucose homeostasis. Unlike the other two receptors, GIPR has at least 13 reported splice varian...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-10, Vol.120 (41), p.e2306145120-e2306145120
Hauptverfasser:	Zhao, Fenghui, Hang, Kaini, Zhou, Qingtong, Shao, Lijun, Li, Hao, Li, Wenzhuo, Lin, Shi, Dai, Antao, Cai, Xiaoqing, Liu, Yanyun, Xu, Yingna, Feng, Wenbo, Yang, Dehua, Wang, Ming-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adenosine Alternative splicing Arrestin Binding Biological Sciences Cell surface Conformation Cyclic AMP GIP protein Glucagon Glucagon-like peptide 1 Glucose Growth hormone-releasing hormone Growth hormones Helices Homeostasis Ligands Localization Metabolic disorders Peptides Polypeptides Receptors Signal transduction Therapeutic targets
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