Structural insights into the complex of oncogenic KRas4BG12V and Rgl2, a RalA/B activator

About a quarter of total human cancers carry mutations in Ras isoforms. Accumulating evidence suggests that small GTPases, RalA, and RalB, and their activators, Ral guanine nucleotide exchange factors (RalGEFs), play an essential role in oncogenic Ras-induced signalling. We studied the interaction b...

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Veröffentlicht in:	Life science alliance 2024-01, Vol.7 (1)
Hauptverfasser:	Tariq, Mishal, Ikeya, Teppei, Togashi, Naoyuki, Fairall, Louise, Kamei, Shun, Mayooramurugan, Sannojah, Abbott, Lauren R, Hasan, Anab, Bueno-Alejo, Carlos, Sukegawa, Sakura, Romartinez-Alonso, Beatriz, Muro Campillo, Miguel Angel, Hudson, Andrew J, Ito, Yutaka, Schwabe, John Wr, Dominguez, Cyril, Tanaka, Kayoko
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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