Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism
Individuals with autism spectrum disorder (henceforth referred to as autism) display significant variation in clinical outcome. For instance, across age, some individuals’ adaptive skills naturally improve or remain stable, while others’ decrease. To pave the way for ‘precision-medicine’ approaches,...
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| Veröffentlicht in: | Molecular psychiatry 2023-05, Vol.28 (5), p.2158-2169 |
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| creator | Pretzsch, Charlotte M. Floris, Dorothea L. Schäfer, Tim Bletsch, Anke Gurr, Caroline Lombardo, Michael V. Chatham, Chris H. Tillmann, Julian Charman, Tony Arenella, Martina Jones, Emily Ambrosino, Sara Bourgeron, Thomas Dumas, Guillaume Cliquet, Freddy Leblond, Claire S. Loth, Eva Oakley, Bethany Buitelaar, Jan K. Baron-Cohen, Simon Beckmann, Christian F. Persico, Antonio M. Banaschewski, Tobias Durston, Sarah Freitag, Christine M. Murphy, Declan G. M. Ecker, Christine |
| description | Individuals with autism spectrum disorder (henceforth referred to as autism) display significant variation in clinical outcome. For instance, across age, some individuals’ adaptive skills naturally improve or remain stable, while others’ decrease. To pave the way for ‘precision-medicine’ approaches, it is crucial to identify the cross-sectional and, given the developmental nature of autism, longitudinal neurobiological (including neuroanatomical and linked genetic) correlates of this variation. We conducted a longitudinal follow-up study of 333 individuals (161 autistic and 172 neurotypical individuals, aged 6–30 years), with two assessment time points separated by ~12–24 months. We collected behavioural (Vineland Adaptive Behaviour Scale-II, VABS-II) and neuroanatomical (structural magnetic resonance imaging) data. Autistic participants were grouped into clinically meaningful “Increasers”, “No-changers”, and “Decreasers” in adaptive behaviour (based on VABS-II scores). We compared each clinical subgroup’s neuroanatomy (surface area and cortical thickness at T1, ∆T (intra-individual change) and T2) to that of the neurotypicals. Next, we explored the neuroanatomical differences’ potential genomic associates using the Allen Human Brain Atlas. Clinical subgroups had distinct neuroanatomical profiles in surface area and cortical thickness at baseline, neuroanatomical development, and follow-up. These profiles were enriched for genes previously associated with autism and for genes previously linked to neurobiological pathways implicated in autism (e.g. excitation-inhibition systems). Our findings suggest that distinct clinical outcomes (i.e. intra-individual change in clinical profiles) linked to autism core symptoms are associated with atypical cross-sectional and longitudinal, i.e. developmental, neurobiological profiles. If validated, our findings may advance the development of interventions, e.g. targeting mechanisms linked to relatively poorer outcomes. |
| doi_str_mv | 10.1038/s41380-023-02016-z |
| format | Article |
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M. ; Ecker, Christine</creator><creatorcontrib>Pretzsch, Charlotte M. ; Floris, Dorothea L. ; Schäfer, Tim ; Bletsch, Anke ; Gurr, Caroline ; Lombardo, Michael V. ; Chatham, Chris H. ; Tillmann, Julian ; Charman, Tony ; Arenella, Martina ; Jones, Emily ; Ambrosino, Sara ; Bourgeron, Thomas ; Dumas, Guillaume ; Cliquet, Freddy ; Leblond, Claire S. ; Loth, Eva ; Oakley, Bethany ; Buitelaar, Jan K. ; Baron-Cohen, Simon ; Beckmann, Christian F. ; Persico, Antonio M. ; Banaschewski, Tobias ; Durston, Sarah ; Freitag, Christine M. ; Murphy, Declan G. M. ; Ecker, Christine ; EU-AIMS/AIMS-2-TRIALS Consortium</creatorcontrib><description>Individuals with autism spectrum disorder (henceforth referred to as autism) display significant variation in clinical outcome. For instance, across age, some individuals’ adaptive skills naturally improve or remain stable, while others’ decrease. To pave the way for ‘precision-medicine’ approaches, it is crucial to identify the cross-sectional and, given the developmental nature of autism, longitudinal neurobiological (including neuroanatomical and linked genetic) correlates of this variation. We conducted a longitudinal follow-up study of 333 individuals (161 autistic and 172 neurotypical individuals, aged 6–30 years), with two assessment time points separated by ~12–24 months. We collected behavioural (Vineland Adaptive Behaviour Scale-II, VABS-II) and neuroanatomical (structural magnetic resonance imaging) data. Autistic participants were grouped into clinically meaningful “Increasers”, “No-changers”, and “Decreasers” in adaptive behaviour (based on VABS-II scores). We compared each clinical subgroup’s neuroanatomy (surface area and cortical thickness at T1, ∆T (intra-individual change) and T2) to that of the neurotypicals. Next, we explored the neuroanatomical differences’ potential genomic associates using the Allen Human Brain Atlas. Clinical subgroups had distinct neuroanatomical profiles in surface area and cortical thickness at baseline, neuroanatomical development, and follow-up. These profiles were enriched for genes previously associated with autism and for genes previously linked to neurobiological pathways implicated in autism (e.g. excitation-inhibition systems). Our findings suggest that distinct clinical outcomes (i.e. intra-individual change in clinical profiles) linked to autism core symptoms are associated with atypical cross-sectional and longitudinal, i.e. developmental, neurobiological profiles. If validated, our findings may advance the development of interventions, e.g. targeting mechanisms linked to relatively poorer outcomes.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-023-02016-z</identifier><identifier>PMID: 36991132</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/208 ; 631/378 ; 692/699/476/1373 ; Anatomy ; Autism ; Behavioral Sciences ; Biological Psychology ; Brain architecture ; Cognitive science ; Genetic diversity ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; Neurobiology ; Neuroimaging ; Neuroscience ; Neurosciences ; Pharmacotherapy ; Psychiatry ; Surface area</subject><ispartof>Molecular psychiatry, 2023-05, Vol.28 (5), p.2158-2169</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. 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These profiles were enriched for genes previously associated with autism and for genes previously linked to neurobiological pathways implicated in autism (e.g. excitation-inhibition systems). Our findings suggest that distinct clinical outcomes (i.e. intra-individual change in clinical profiles) linked to autism core symptoms are associated with atypical cross-sectional and longitudinal, i.e. developmental, neurobiological profiles. 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M.</au><au>Ecker, Christine</au><aucorp>EU-AIMS/AIMS-2-TRIALS Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>28</volume><issue>5</issue><spage>2158</spage><epage>2169</epage><pages>2158-2169</pages><issn>1359-4184</issn><eissn>1476-5578</eissn><abstract>Individuals with autism spectrum disorder (henceforth referred to as autism) display significant variation in clinical outcome. For instance, across age, some individuals’ adaptive skills naturally improve or remain stable, while others’ decrease. To pave the way for ‘precision-medicine’ approaches, it is crucial to identify the cross-sectional and, given the developmental nature of autism, longitudinal neurobiological (including neuroanatomical and linked genetic) correlates of this variation. We conducted a longitudinal follow-up study of 333 individuals (161 autistic and 172 neurotypical individuals, aged 6–30 years), with two assessment time points separated by ~12–24 months. We collected behavioural (Vineland Adaptive Behaviour Scale-II, VABS-II) and neuroanatomical (structural magnetic resonance imaging) data. Autistic participants were grouped into clinically meaningful “Increasers”, “No-changers”, and “Decreasers” in adaptive behaviour (based on VABS-II scores). We compared each clinical subgroup’s neuroanatomy (surface area and cortical thickness at T1, ∆T (intra-individual change) and T2) to that of the neurotypicals. Next, we explored the neuroanatomical differences’ potential genomic associates using the Allen Human Brain Atlas. Clinical subgroups had distinct neuroanatomical profiles in surface area and cortical thickness at baseline, neuroanatomical development, and follow-up. These profiles were enriched for genes previously associated with autism and for genes previously linked to neurobiological pathways implicated in autism (e.g. excitation-inhibition systems). Our findings suggest that distinct clinical outcomes (i.e. intra-individual change in clinical profiles) linked to autism core symptoms are associated with atypical cross-sectional and longitudinal, i.e. developmental, neurobiological profiles. If validated, our findings may advance the development of interventions, e.g. targeting mechanisms linked to relatively poorer outcomes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36991132</pmid><doi>10.1038/s41380-023-02016-z</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4595-1144</orcidid><orcidid>https://orcid.org/0000-0001-8288-7757</orcidid><orcidid>https://orcid.org/0000-0002-6664-7451</orcidid><orcidid>https://orcid.org/0000-0002-6857-4065</orcidid><orcidid>https://orcid.org/0000-0001-9217-2544</orcidid><orcidid>https://orcid.org/0000-0002-9989-0685</orcidid><orcidid>https://orcid.org/0000-0002-2761-6628</orcidid><orcidid>https://orcid.org/0000-0002-3683-8070</orcidid><orcidid>https://orcid.org/0000-0003-1993-6549</orcidid><orcidid>https://orcid.org/0000-0002-2253-1844</orcidid><orcidid>https://orcid.org/0000-0001-9458-9167</orcidid><orcidid>https://orcid.org/0000-0003-4427-8285</orcidid><orcidid>https://orcid.org/0000-0001-8164-9220</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 2023-05, Vol.28 (5), p.2158-2169 |
| issn | 1359-4184 1476-5578 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10575772 |
| source | Springer Nature - Complete Springer Journals |
| subjects | 59/57 631/208 631/378 692/699/476/1373 Anatomy Autism Behavioral Sciences Biological Psychology Brain architecture Cognitive science Genetic diversity Magnetic resonance imaging Medicine Medicine & Public Health Neurobiology Neuroimaging Neuroscience Neurosciences Pharmacotherapy Psychiatry Surface area |
| title | Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A55%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cross-sectional%20and%20longitudinal%20neuroanatomical%20profiles%20of%20distinct%20clinical%20(adaptive)%20outcomes%20in%20autism&rft.jtitle=Molecular%20psychiatry&rft.au=Pretzsch,%20Charlotte%20M.&rft.aucorp=EU-AIMS/AIMS-2-TRIALS%20Consortium&rft.date=2023-05-01&rft.volume=28&rft.issue=5&rft.spage=2158&rft.epage=2169&rft.pages=2158-2169&rft.issn=1359-4184&rft.eissn=1476-5578&rft_id=info:doi/10.1038/s41380-023-02016-z&rft_dat=%3Cproquest_pubme%3E2876775256%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2876775256&rft_id=info:pmid/36991132&rfr_iscdi=true |