Adjuvant radiotherapy mitigates impact of perineural invasion on oncologic outcomes in early-stage oral cavity squamous cell carcinoma. A multi-institutional analysis of 557 patients

•Perineural invasion is associated with worse disease control in oral squamous cell carcinoma.•Early-stage oral cancers with perineural invasion have worse disease-free survival.•Radiation mitigates hazard for disease-free survival in perineural invasion positive cancers. Understand the prognostic i...

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Veröffentlicht in:	Oral oncology 2023-07, Vol.142, p.106420-106420, Article 106420
Hauptverfasser:	Holcomb, Andrew J., Farrokhian, Nathan, Tolan, Claire, Whiteford, Erin, Villwock, Mark, Kakarala, Kiran, Shnayder, Yelizaveta, Sykes, Kevin, Lominska, Christopher, Gan, Gregory, Buchakjian, Marisa R., Harding, Brette, Dooley, Laura, Shinn, Justin, Burton Wood, C., Rohde, Sarah, Khaja, Sobia, Abt, Nicholas B., Varvares, Mark, Bur, Andrés M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant radiation Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - surgery Cohort Studies Female Head and neck cancer Head and Neck Neoplasms - pathology Humans Male Middle Aged Mouth Neoplasms - radiotherapy Mouth Neoplasms - surgery Neoplasm Invasiveness - pathology Neoplasm Staging Oral cancer Perineural invasion Prognosis Radiation Radiotherapy, Adjuvant Retrospective Studies Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - pathology
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