Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis

Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility...

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Veröffentlicht in:International journal of molecular sciences 2023-10, Vol.24 (19), p.14930
Hauptverfasser: Peña-Corona, Sheila I, Chávez-Corona, Juan I, Pérez-Caltzontzin, Luis E, Vargas-Estrada, Dinorah, Mendoza-Rodríguez, C. Adriana, Ramos-Martínez, Edgar, Cerbón-Gutiérrez, Jose L, Herrera-Barragán, José A, Quintanar-Guerrero, David, Leyva-Gómez, Gerardo
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container_end_page
container_issue 19
container_start_page 14930
container_title International journal of molecular sciences
container_volume 24
creator Peña-Corona, Sheila I
Chávez-Corona, Juan I
Pérez-Caltzontzin, Luis E
Vargas-Estrada, Dinorah
Mendoza-Rodríguez, C. Adriana
Ramos-Martínez, Edgar
Cerbón-Gutiérrez, Jose L
Herrera-Barragán, José A
Quintanar-Guerrero, David
Leyva-Gómez, Gerardo
description Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols.
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Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. 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subjects Amino acids
Androgens
Antioxidants
Bisphenol A
Endocrine disruptors
Estrogen
Estrogens
Fatty acids
Melatonin
Meta-analysis
Morphology
Motility
Phthalates
Review
Sperm
Systematic review
Testosterone
Toxicity
Vitamin E
Vitamins
title Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis
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