Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis
Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility...
Gespeichert in:
Veröffentlicht in: | International journal of molecular sciences 2023-10, Vol.24 (19), p.14930 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 19 |
container_start_page | 14930 |
container_title | International journal of molecular sciences |
container_volume | 24 |
creator | Peña-Corona, Sheila I Chávez-Corona, Juan I Pérez-Caltzontzin, Luis E Vargas-Estrada, Dinorah Mendoza-Rodríguez, C. Adriana Ramos-Martínez, Edgar Cerbón-Gutiérrez, Jose L Herrera-Barragán, José A Quintanar-Guerrero, David Leyva-Gómez, Gerardo |
description | Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols. |
doi_str_mv | 10.3390/ijms241914930 |
format | Article |
fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10573514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A771910355</galeid><sourcerecordid>A771910355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c460t-5ac1dad4477e94f973230e8ba697468154a1c1fc7637da0c634f2ff0b3da20c03</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEoqVw5G6JC5cUO3bihEu1VAUqdQWCAkdr1hlvvErsre1d2H_Cz8XdVsAiZMkf4-d9xyNPUTxn9JTzjr6yqylWgnVMdJw-KI6ZqKqS0kY-_Gt_VDyJcUVpxau6e1wccdlykafj4uccR0jeWUfA9eSrTTBZFwlE8jH4hDr5kE9LyMFE0oDkE66D7zc62S2Sa__Dapt2xBvyxsb1gM6P8TX5Nlg9kMu4V8x9ll4Yg3vNGZmRz7uYcIJkdbbbWvy-Tz7HBOXMwbiLNj4tHhkYIz67X0-KL28vrs_fl1cf3l2ez65KLRqayho066EXQkrshOkkrzjFdgFNJ0XTsloA08xo2XDZA9UNF6Yyhi54DxXVlJ8UZ3e-681iwl6jSwFGtQ52grBTHqw6vHF2UEu_VYzWktdMZIeX9w7B32wwJjXZqHEcwaHfRFW1UvKuYqzN6It_0JXfhFzxnmryi2Un_lBLGFFZZ3xOrG9N1UzK_NWU13WmTv9D5dHjZLV3aGyOHwjKO4EOPsaA5neRjKrbXlIHvcR_AdQGvBs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2876746794</pqid></control><display><type>article</type><title>Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Peña-Corona, Sheila I ; Chávez-Corona, Juan I ; Pérez-Caltzontzin, Luis E ; Vargas-Estrada, Dinorah ; Mendoza-Rodríguez, C. Adriana ; Ramos-Martínez, Edgar ; Cerbón-Gutiérrez, Jose L ; Herrera-Barragán, José A ; Quintanar-Guerrero, David ; Leyva-Gómez, Gerardo</creator><creatorcontrib>Peña-Corona, Sheila I ; Chávez-Corona, Juan I ; Pérez-Caltzontzin, Luis E ; Vargas-Estrada, Dinorah ; Mendoza-Rodríguez, C. Adriana ; Ramos-Martínez, Edgar ; Cerbón-Gutiérrez, Jose L ; Herrera-Barragán, José A ; Quintanar-Guerrero, David ; Leyva-Gómez, Gerardo</creatorcontrib><description>Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241914930</identifier><identifier>PMID: 37834378</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Amino acids ; Androgens ; Antioxidants ; Bisphenol A ; Endocrine disruptors ; Estrogen ; Estrogens ; Fatty acids ; Melatonin ; Meta-analysis ; Morphology ; Motility ; Phthalates ; Review ; Sperm ; Systematic review ; Testosterone ; Toxicity ; Vitamin E ; Vitamins</subject><ispartof>International journal of molecular sciences, 2023-10, Vol.24 (19), p.14930</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-5ac1dad4477e94f973230e8ba697468154a1c1fc7637da0c634f2ff0b3da20c03</citedby><cites>FETCH-LOGICAL-c460t-5ac1dad4477e94f973230e8ba697468154a1c1fc7637da0c634f2ff0b3da20c03</cites><orcidid>0000-0002-7940-1100 ; 0000-0002-0881-0943 ; 0000-0001-5399-609X ; 0000-0003-2982-1315 ; 0000-0003-3985-3628</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573514/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573514/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><creatorcontrib>Peña-Corona, Sheila I</creatorcontrib><creatorcontrib>Chávez-Corona, Juan I</creatorcontrib><creatorcontrib>Pérez-Caltzontzin, Luis E</creatorcontrib><creatorcontrib>Vargas-Estrada, Dinorah</creatorcontrib><creatorcontrib>Mendoza-Rodríguez, C. Adriana</creatorcontrib><creatorcontrib>Ramos-Martínez, Edgar</creatorcontrib><creatorcontrib>Cerbón-Gutiérrez, Jose L</creatorcontrib><creatorcontrib>Herrera-Barragán, José A</creatorcontrib><creatorcontrib>Quintanar-Guerrero, David</creatorcontrib><creatorcontrib>Leyva-Gómez, Gerardo</creatorcontrib><title>Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis</title><title>International journal of molecular sciences</title><description>Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols.</description><subject>Amino acids</subject><subject>Androgens</subject><subject>Antioxidants</subject><subject>Bisphenol A</subject><subject>Endocrine disruptors</subject><subject>Estrogen</subject><subject>Estrogens</subject><subject>Fatty acids</subject><subject>Melatonin</subject><subject>Meta-analysis</subject><subject>Morphology</subject><subject>Motility</subject><subject>Phthalates</subject><subject>Review</subject><subject>Sperm</subject><subject>Systematic review</subject><subject>Testosterone</subject><subject>Toxicity</subject><subject>Vitamin E</subject><subject>Vitamins</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v1DAQhiMEoqVw5G6JC5cUO3bihEu1VAUqdQWCAkdr1hlvvErsre1d2H_Cz8XdVsAiZMkf4-d9xyNPUTxn9JTzjr6yqylWgnVMdJw-KI6ZqKqS0kY-_Gt_VDyJcUVpxau6e1wccdlykafj4uccR0jeWUfA9eSrTTBZFwlE8jH4hDr5kE9LyMFE0oDkE66D7zc62S2Sa__Dapt2xBvyxsb1gM6P8TX5Nlg9kMu4V8x9ll4Yg3vNGZmRz7uYcIJkdbbbWvy-Tz7HBOXMwbiLNj4tHhkYIz67X0-KL28vrs_fl1cf3l2ez65KLRqayho066EXQkrshOkkrzjFdgFNJ0XTsloA08xo2XDZA9UNF6Yyhi54DxXVlJ8UZ3e-681iwl6jSwFGtQ52grBTHqw6vHF2UEu_VYzWktdMZIeX9w7B32wwJjXZqHEcwaHfRFW1UvKuYqzN6It_0JXfhFzxnmryi2Un_lBLGFFZZ3xOrG9N1UzK_NWU13WmTv9D5dHjZLV3aGyOHwjKO4EOPsaA5neRjKrbXlIHvcR_AdQGvBs</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Peña-Corona, Sheila I</creator><creator>Chávez-Corona, Juan I</creator><creator>Pérez-Caltzontzin, Luis E</creator><creator>Vargas-Estrada, Dinorah</creator><creator>Mendoza-Rodríguez, C. Adriana</creator><creator>Ramos-Martínez, Edgar</creator><creator>Cerbón-Gutiérrez, Jose L</creator><creator>Herrera-Barragán, José A</creator><creator>Quintanar-Guerrero, David</creator><creator>Leyva-Gómez, Gerardo</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7940-1100</orcidid><orcidid>https://orcid.org/0000-0002-0881-0943</orcidid><orcidid>https://orcid.org/0000-0001-5399-609X</orcidid><orcidid>https://orcid.org/0000-0003-2982-1315</orcidid><orcidid>https://orcid.org/0000-0003-3985-3628</orcidid></search><sort><creationdate>20231001</creationdate><title>Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis</title><author>Peña-Corona, Sheila I ; Chávez-Corona, Juan I ; Pérez-Caltzontzin, Luis E ; Vargas-Estrada, Dinorah ; Mendoza-Rodríguez, C. Adriana ; Ramos-Martínez, Edgar ; Cerbón-Gutiérrez, Jose L ; Herrera-Barragán, José A ; Quintanar-Guerrero, David ; Leyva-Gómez, Gerardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-5ac1dad4477e94f973230e8ba697468154a1c1fc7637da0c634f2ff0b3da20c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amino acids</topic><topic>Androgens</topic><topic>Antioxidants</topic><topic>Bisphenol A</topic><topic>Endocrine disruptors</topic><topic>Estrogen</topic><topic>Estrogens</topic><topic>Fatty acids</topic><topic>Melatonin</topic><topic>Meta-analysis</topic><topic>Morphology</topic><topic>Motility</topic><topic>Phthalates</topic><topic>Review</topic><topic>Sperm</topic><topic>Systematic review</topic><topic>Testosterone</topic><topic>Toxicity</topic><topic>Vitamin E</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peña-Corona, Sheila I</creatorcontrib><creatorcontrib>Chávez-Corona, Juan I</creatorcontrib><creatorcontrib>Pérez-Caltzontzin, Luis E</creatorcontrib><creatorcontrib>Vargas-Estrada, Dinorah</creatorcontrib><creatorcontrib>Mendoza-Rodríguez, C. Adriana</creatorcontrib><creatorcontrib>Ramos-Martínez, Edgar</creatorcontrib><creatorcontrib>Cerbón-Gutiérrez, Jose L</creatorcontrib><creatorcontrib>Herrera-Barragán, José A</creatorcontrib><creatorcontrib>Quintanar-Guerrero, David</creatorcontrib><creatorcontrib>Leyva-Gómez, Gerardo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peña-Corona, Sheila I</au><au>Chávez-Corona, Juan I</au><au>Pérez-Caltzontzin, Luis E</au><au>Vargas-Estrada, Dinorah</au><au>Mendoza-Rodríguez, C. Adriana</au><au>Ramos-Martínez, Edgar</au><au>Cerbón-Gutiérrez, Jose L</au><au>Herrera-Barragán, José A</au><au>Quintanar-Guerrero, David</au><au>Leyva-Gómez, Gerardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis</atitle><jtitle>International journal of molecular sciences</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>24</volume><issue>19</issue><spage>14930</spage><pages>14930-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Bisphenols such as bisphenol A (BPA), S (BPS), C (BPC), F (BPF), AF (BPAF), tetrabromobisphenol, nonylphenol, and octylphenol are plasticizers used worldwide to manufacture daily-use articles. Exposure to these compounds is related to many pathologies of public health importance, such as infertility. Using a protector compound against the reproductive toxicological effects of bisphenols is of scientific interest. Melatonin and vitamins have been tested, but the results are not conclusive. To this end, this systematic review and meta-analysis compared the response of reproductive variables to melatonin and vitamin administration as protectors against damage caused by bisphenols. We search for controlled studies of male rats exposed to bisphenols to induce alterations in reproduction, with at least one intervention group receiving melatonin or vitamins (B, C, or E). Also, molecular docking simulations were performed between the androgen (AR) and estrogen receptors (ER), melatonin, and vitamins. About 1234 records were initially found; finally, 13 studies were qualified for review and meta-analysis. Melatonin plus bisphenol improves sperm concentration and viability of sperm and increases testosterone serum levels compared with control groups; however, groups receiving vitamins plus bisphenols had lower sperm concentration, total testis weight, and testosterone serum levels than the control. In the docking analysis, vitamin E had the highest negative MolDock score, representing the best binding affinity with AR and ER, compared with other vitamins and melatonin in the docking. Our findings suggest that vitamins could act as an endocrine disruptor, and melatonin is most effective in protecting against the toxic effects of bisphenols.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>37834378</pmid><doi>10.3390/ijms241914930</doi><orcidid>https://orcid.org/0000-0002-7940-1100</orcidid><orcidid>https://orcid.org/0000-0002-0881-0943</orcidid><orcidid>https://orcid.org/0000-0001-5399-609X</orcidid><orcidid>https://orcid.org/0000-0003-2982-1315</orcidid><orcidid>https://orcid.org/0000-0003-3985-3628</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1422-0067 |
ispartof | International journal of molecular sciences, 2023-10, Vol.24 (19), p.14930 |
issn | 1422-0067 1661-6596 1422-0067 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10573514 |
source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Amino acids Androgens Antioxidants Bisphenol A Endocrine disruptors Estrogen Estrogens Fatty acids Melatonin Meta-analysis Morphology Motility Phthalates Review Sperm Systematic review Testosterone Toxicity Vitamin E Vitamins |
title | Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T13%3A16%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Melatonin%20and%20Vitamins%20as%20Protectors%20against%20the%20Reproductive%20Toxicity%20of%20Bisphenols:%20Which%20Is%20the%20Most%20Effective?%20A%20Systematic%20Review%20and%20Meta-Analysis&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Pe%C3%B1a-Corona,%20Sheila%20I&rft.date=2023-10-01&rft.volume=24&rft.issue=19&rft.spage=14930&rft.pages=14930-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms241914930&rft_dat=%3Cgale_pubme%3EA771910355%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2876746794&rft_id=info:pmid/37834378&rft_galeid=A771910355&rfr_iscdi=true |