Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study
Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients fr...
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| Veröffentlicht in: | Journal of clinical medicine 2023-09, Vol.12 (19), p.6255 |
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| creator | Kim, Dong-Hyun Jung, Yong-Wook Jin, Byung-Chul Oh, Hyung-Hoon Song, Hyo-Yeop Kim, Seong-Jung Myung, Dae-Seong Kim, Sang-Wook Lee, Jun Seo, Geom-Seog Joo, Young-Eun Kim, Hyun-Soo |
| description | Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients from five tertiary medical centers. The Charlson Comorbidity Index (CCI) and age-adjusted CCI (ACCI) were analyzed, and the differences in complete resection and complication rates were analyzed. The CCI, ACCI, and complication rates tended to gradually increase proportionally, and the complication resection rate increased from CCI 2 to ACCI 4 as the starting point, followed by a decreasing trend. Of these, 140 patients (9.7%) had a CCI score of 3 or higher. The high CCI group was older (70.6% vs. 64.7%, p < 0.01) and had a higher proportion of men (70.7% vs. 58.7%, p < 0.01) than the low CCI group. The high CCI group had a higher incidence of cancer than the low CCI group (77.9% vs. 65.2%, p < 0.01). The en bloc resection rate (90.0% vs. 89.3%, p = 0.79) and complete resection rate (75.7% vs. 81.2%, p = 0.12) were not significantly different between the two groups. Colorectal ESD can be safely and effectively performed in patients with various underlying medical conditions. |
| doi_str_mv | 10.3390/jcm12196255 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10573342</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A772064773</galeid><sourcerecordid>A772064773</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-47d249ee6567584d81d936619a8bae9681a37c828c299c8f2dc9bd43143ca563</originalsourceid><addsrcrecordid>eNptUstqGzEUHUpLE9Ks-gOCbgrFyegxI6mbYiZubEgfMNkLWQ9bRiO50kxS_1C_szIJbVIqLXSle865OtxbVW9hfYExry93aoAI8hY1zYvqFNWUzmrM8Msn8Ul1nvOuLosxgiB9XZ1gyjBhnJ9WvxbWGjW6OxNMzkAGDXppzXgA0YJF0DGruHcK9NN6mFTM0oMrl_OREgOwMYEu-pjKvWS-mrj3Mg_ABfBdjs6EMYN7N27B0m22oNvK5HOhdXGIae20K2VWQZufoFdF4yOYg-W8X12BL5MfnSp0k0A_Tvrwpnplpc_m_PE8q24_L2675ezm2_Wqm9_MFIFonBGqEeHGtE1LG0Y0g5rjtoVcsrU0vGVQYqoYYgpxrphFWvG1JhgSrGTT4rPq04Psvtg1-viDJL3YJzfIdBBROvE8E9xWbOKdgHVDMSaoKLx_VEjxx2TyKAaXlfFeBhOnLBCjtPQNw6ZA3_0D3cUphWLviGpLf2CD_qI20hvhgo2lsDqKijmlqG5JESyoi_-gytZmcCoGY115f0b48EBQKeacjP1jEtbiOFniyWTh37Kev8A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2876489152</pqid></control><display><type>article</type><title>Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Kim, Dong-Hyun ; Jung, Yong-Wook ; Jin, Byung-Chul ; Oh, Hyung-Hoon ; Song, Hyo-Yeop ; Kim, Seong-Jung ; Myung, Dae-Seong ; Kim, Sang-Wook ; Lee, Jun ; Seo, Geom-Seog ; Joo, Young-Eun ; Kim, Hyun-Soo</creator><creatorcontrib>Kim, Dong-Hyun ; Jung, Yong-Wook ; Jin, Byung-Chul ; Oh, Hyung-Hoon ; Song, Hyo-Yeop ; Kim, Seong-Jung ; Myung, Dae-Seong ; Kim, Sang-Wook ; Lee, Jun ; Seo, Geom-Seog ; Joo, Young-Eun ; Kim, Hyun-Soo</creatorcontrib><description>Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients from five tertiary medical centers. The Charlson Comorbidity Index (CCI) and age-adjusted CCI (ACCI) were analyzed, and the differences in complete resection and complication rates were analyzed. The CCI, ACCI, and complication rates tended to gradually increase proportionally, and the complication resection rate increased from CCI 2 to ACCI 4 as the starting point, followed by a decreasing trend. Of these, 140 patients (9.7%) had a CCI score of 3 or higher. The high CCI group was older (70.6% vs. 64.7%, p < 0.01) and had a higher proportion of men (70.7% vs. 58.7%, p < 0.01) than the low CCI group. The high CCI group had a higher incidence of cancer than the low CCI group (77.9% vs. 65.2%, p < 0.01). The en bloc resection rate (90.0% vs. 89.3%, p = 0.79) and complete resection rate (75.7% vs. 81.2%, p = 0.12) were not significantly different between the two groups. Colorectal ESD can be safely and effectively performed in patients with various underlying medical conditions.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12196255</identifier><identifier>PMID: 37834899</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age ; Anesthesia ; Blood pressure ; Cancer ; Care and treatment ; Clinical medicine ; Clinical outcomes ; Colorectal cancer ; Comorbidity ; Data collection ; Diabetes ; Diagnosis ; Dissection ; Endoscopy ; Hospitals ; Intestine, Large ; Liver diseases ; Medical prognosis ; Medical research ; Mortality ; Oxygen saturation ; Patient outcomes ; Patients ; Relapse ; Surgery ; Tumors</subject><ispartof>Journal of clinical medicine, 2023-09, Vol.12 (19), p.6255</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c412t-47d249ee6567584d81d936619a8bae9681a37c828c299c8f2dc9bd43143ca563</cites><orcidid>0000-0001-5778-1264 ; 0000-0003-0422-2439</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573342/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573342/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Jung, Yong-Wook</creatorcontrib><creatorcontrib>Jin, Byung-Chul</creatorcontrib><creatorcontrib>Oh, Hyung-Hoon</creatorcontrib><creatorcontrib>Song, Hyo-Yeop</creatorcontrib><creatorcontrib>Kim, Seong-Jung</creatorcontrib><creatorcontrib>Myung, Dae-Seong</creatorcontrib><creatorcontrib>Kim, Sang-Wook</creatorcontrib><creatorcontrib>Lee, Jun</creatorcontrib><creatorcontrib>Seo, Geom-Seog</creatorcontrib><creatorcontrib>Joo, Young-Eun</creatorcontrib><creatorcontrib>Kim, Hyun-Soo</creatorcontrib><title>Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study</title><title>Journal of clinical medicine</title><description>Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients from five tertiary medical centers. The Charlson Comorbidity Index (CCI) and age-adjusted CCI (ACCI) were analyzed, and the differences in complete resection and complication rates were analyzed. The CCI, ACCI, and complication rates tended to gradually increase proportionally, and the complication resection rate increased from CCI 2 to ACCI 4 as the starting point, followed by a decreasing trend. Of these, 140 patients (9.7%) had a CCI score of 3 or higher. The high CCI group was older (70.6% vs. 64.7%, p < 0.01) and had a higher proportion of men (70.7% vs. 58.7%, p < 0.01) than the low CCI group. The high CCI group had a higher incidence of cancer than the low CCI group (77.9% vs. 65.2%, p < 0.01). The en bloc resection rate (90.0% vs. 89.3%, p = 0.79) and complete resection rate (75.7% vs. 81.2%, p = 0.12) were not significantly different between the two groups. Colorectal ESD can be safely and effectively performed in patients with various underlying medical conditions.</description><subject>Age</subject><subject>Anesthesia</subject><subject>Blood pressure</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Clinical medicine</subject><subject>Clinical outcomes</subject><subject>Colorectal cancer</subject><subject>Comorbidity</subject><subject>Data collection</subject><subject>Diabetes</subject><subject>Diagnosis</subject><subject>Dissection</subject><subject>Endoscopy</subject><subject>Hospitals</subject><subject>Intestine, Large</subject><subject>Liver diseases</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Mortality</subject><subject>Oxygen saturation</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Relapse</subject><subject>Surgery</subject><subject>Tumors</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptUstqGzEUHUpLE9Ks-gOCbgrFyegxI6mbYiZubEgfMNkLWQ9bRiO50kxS_1C_szIJbVIqLXSle865OtxbVW9hfYExry93aoAI8hY1zYvqFNWUzmrM8Msn8Ul1nvOuLosxgiB9XZ1gyjBhnJ9WvxbWGjW6OxNMzkAGDXppzXgA0YJF0DGruHcK9NN6mFTM0oMrl_OREgOwMYEu-pjKvWS-mrj3Mg_ABfBdjs6EMYN7N27B0m22oNvK5HOhdXGIae20K2VWQZufoFdF4yOYg-W8X12BL5MfnSp0k0A_Tvrwpnplpc_m_PE8q24_L2675ezm2_Wqm9_MFIFonBGqEeHGtE1LG0Y0g5rjtoVcsrU0vGVQYqoYYgpxrphFWvG1JhgSrGTT4rPq04Psvtg1-viDJL3YJzfIdBBROvE8E9xWbOKdgHVDMSaoKLx_VEjxx2TyKAaXlfFeBhOnLBCjtPQNw6ZA3_0D3cUphWLviGpLf2CD_qI20hvhgo2lsDqKijmlqG5JESyoi_-gytZmcCoGY115f0b48EBQKeacjP1jEtbiOFniyWTh37Kev8A</recordid><startdate>20230928</startdate><enddate>20230928</enddate><creator>Kim, Dong-Hyun</creator><creator>Jung, Yong-Wook</creator><creator>Jin, Byung-Chul</creator><creator>Oh, Hyung-Hoon</creator><creator>Song, Hyo-Yeop</creator><creator>Kim, Seong-Jung</creator><creator>Myung, Dae-Seong</creator><creator>Kim, Sang-Wook</creator><creator>Lee, Jun</creator><creator>Seo, Geom-Seog</creator><creator>Joo, Young-Eun</creator><creator>Kim, Hyun-Soo</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5778-1264</orcidid><orcidid>https://orcid.org/0000-0003-0422-2439</orcidid></search><sort><creationdate>20230928</creationdate><title>Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study</title><author>Kim, Dong-Hyun ; Jung, Yong-Wook ; Jin, Byung-Chul ; Oh, Hyung-Hoon ; Song, Hyo-Yeop ; Kim, Seong-Jung ; Myung, Dae-Seong ; Kim, Sang-Wook ; Lee, Jun ; Seo, Geom-Seog ; Joo, Young-Eun ; Kim, Hyun-Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-47d249ee6567584d81d936619a8bae9681a37c828c299c8f2dc9bd43143ca563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Anesthesia</topic><topic>Blood pressure</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Clinical medicine</topic><topic>Clinical outcomes</topic><topic>Colorectal cancer</topic><topic>Comorbidity</topic><topic>Data collection</topic><topic>Diabetes</topic><topic>Diagnosis</topic><topic>Dissection</topic><topic>Endoscopy</topic><topic>Hospitals</topic><topic>Intestine, Large</topic><topic>Liver diseases</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Mortality</topic><topic>Oxygen saturation</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Relapse</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Jung, Yong-Wook</creatorcontrib><creatorcontrib>Jin, Byung-Chul</creatorcontrib><creatorcontrib>Oh, Hyung-Hoon</creatorcontrib><creatorcontrib>Song, Hyo-Yeop</creatorcontrib><creatorcontrib>Kim, Seong-Jung</creatorcontrib><creatorcontrib>Myung, Dae-Seong</creatorcontrib><creatorcontrib>Kim, Sang-Wook</creatorcontrib><creatorcontrib>Lee, Jun</creatorcontrib><creatorcontrib>Seo, Geom-Seog</creatorcontrib><creatorcontrib>Joo, Young-Eun</creatorcontrib><creatorcontrib>Kim, Hyun-Soo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Dong-Hyun</au><au>Jung, Yong-Wook</au><au>Jin, Byung-Chul</au><au>Oh, Hyung-Hoon</au><au>Song, Hyo-Yeop</au><au>Kim, Seong-Jung</au><au>Myung, Dae-Seong</au><au>Kim, Sang-Wook</au><au>Lee, Jun</au><au>Seo, Geom-Seog</au><au>Joo, Young-Eun</au><au>Kim, Hyun-Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study</atitle><jtitle>Journal of clinical medicine</jtitle><date>2023-09-28</date><risdate>2023</risdate><volume>12</volume><issue>19</issue><spage>6255</spage><pages>6255-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Endoscopic submucosal dissection (ESD) is an effective method for removing early colorectal lesions. However, research on the safety and efficacy of ESD in patients with various underlying conditions remains limited. This study retrospectively examined ESD outcomes in colorectal neoplasm patients from five tertiary medical centers. The Charlson Comorbidity Index (CCI) and age-adjusted CCI (ACCI) were analyzed, and the differences in complete resection and complication rates were analyzed. The CCI, ACCI, and complication rates tended to gradually increase proportionally, and the complication resection rate increased from CCI 2 to ACCI 4 as the starting point, followed by a decreasing trend. Of these, 140 patients (9.7%) had a CCI score of 3 or higher. The high CCI group was older (70.6% vs. 64.7%, p < 0.01) and had a higher proportion of men (70.7% vs. 58.7%, p < 0.01) than the low CCI group. The high CCI group had a higher incidence of cancer than the low CCI group (77.9% vs. 65.2%, p < 0.01). The en bloc resection rate (90.0% vs. 89.3%, p = 0.79) and complete resection rate (75.7% vs. 81.2%, p = 0.12) were not significantly different between the two groups. Colorectal ESD can be safely and effectively performed in patients with various underlying medical conditions.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>37834899</pmid><doi>10.3390/jcm12196255</doi><orcidid>https://orcid.org/0000-0001-5778-1264</orcidid><orcidid>https://orcid.org/0000-0003-0422-2439</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Anesthesia Blood pressure Cancer Care and treatment Clinical medicine Clinical outcomes Colorectal cancer Comorbidity Data collection Diabetes Diagnosis Dissection Endoscopy Hospitals Intestine, Large Liver diseases Medical prognosis Medical research Mortality Oxygen saturation Patient outcomes Patients Relapse Surgery Tumors |
| title | Effectiveness and Safety of Endoscopic Submucosal Dissection for Colorectal Neoplasm in Patients with High Charlson Comorbidity Index Score: A HASID Multicenter Study |
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