Dynamics of the Microbiota and Its Relationship with Post-COVID-19 Syndrome
Coronavirus disease (COVID-19) is an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can be asymptomatic or present with multiple organ dysfunction. Many infected individuals have chronic alterations associated with neuropsychiatric, endocrine, gastrointestina...
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| Veröffentlicht in: | International journal of molecular sciences 2023-10, Vol.24 (19), p.14822 |
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| creator | Moreno-Corona, Nidia Carolina López-Ortega, Orestes Pérez-Martínez, Cesar Augusto Martínez-Castillo, Macario De Jesús-González, Luis Adrián León-Reyes, Guadalupe León-Juárez, Moisés |
| description | Coronavirus disease (COVID-19) is an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can be asymptomatic or present with multiple organ dysfunction. Many infected individuals have chronic alterations associated with neuropsychiatric, endocrine, gastrointestinal, and musculoskeletal symptoms, even several months after disease onset, developing long-COVID or post-acute COVID-19 syndrome (PACS). Microbiota dysbiosis contributes to the onset and progression of many viral diseases, including COVID-19 and post-COVID-19 manifestations, which could serve as potential diagnostic and prognostic biomarkers. This review aimed to discuss the most recent findings on gut microbiota dysbiosis and its relationship with the sequelae of PACS. Elucidating these mechanisms could help develop personalized and non-invasive clinical strategies to identify individuals at a higher risk of experiencing severe disease progression or complications associated with PACS. Moreover, the review highlights the importance of targeting the gut microbiota composition to avoid dysbiosis and to develop possible prophylactic and therapeutic measures against COVID-19 and PACS in future studies. |
| doi_str_mv | 10.3390/ijms241914822 |
| format | Article |
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Many infected individuals have chronic alterations associated with neuropsychiatric, endocrine, gastrointestinal, and musculoskeletal symptoms, even several months after disease onset, developing long-COVID or post-acute COVID-19 syndrome (PACS). Microbiota dysbiosis contributes to the onset and progression of many viral diseases, including COVID-19 and post-COVID-19 manifestations, which could serve as potential diagnostic and prognostic biomarkers. This review aimed to discuss the most recent findings on gut microbiota dysbiosis and its relationship with the sequelae of PACS. Elucidating these mechanisms could help develop personalized and non-invasive clinical strategies to identify individuals at a higher risk of experiencing severe disease progression or complications associated with PACS. Moreover, the review highlights the importance of targeting the gut microbiota composition to avoid dysbiosis and to develop possible prophylactic and therapeutic measures against COVID-19 and PACS in future studies.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms241914822</identifier><identifier>PMID: 37834270</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>B cells ; Bacteria ; Coronaviruses ; COVID-19 ; Development and progression ; Dyspnea ; Health aspects ; HIV ; Homeostasis ; Human immunodeficiency virus ; Immune system ; Infections ; Inflammation ; Influenza ; Long COVID ; Lung diseases ; Lungs ; Metabolites ; Microbiota ; Microbiota (Symbiotic organisms) ; Pathogens ; Remission (Medicine) ; Review ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Viral infections ; Virus diseases ; Viruses</subject><ispartof>International journal of molecular sciences, 2023-10, Vol.24 (19), p.14822</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Many infected individuals have chronic alterations associated with neuropsychiatric, endocrine, gastrointestinal, and musculoskeletal symptoms, even several months after disease onset, developing long-COVID or post-acute COVID-19 syndrome (PACS). Microbiota dysbiosis contributes to the onset and progression of many viral diseases, including COVID-19 and post-COVID-19 manifestations, which could serve as potential diagnostic and prognostic biomarkers. This review aimed to discuss the most recent findings on gut microbiota dysbiosis and its relationship with the sequelae of PACS. Elucidating these mechanisms could help develop personalized and non-invasive clinical strategies to identify individuals at a higher risk of experiencing severe disease progression or complications associated with PACS. 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Many infected individuals have chronic alterations associated with neuropsychiatric, endocrine, gastrointestinal, and musculoskeletal symptoms, even several months after disease onset, developing long-COVID or post-acute COVID-19 syndrome (PACS). Microbiota dysbiosis contributes to the onset and progression of many viral diseases, including COVID-19 and post-COVID-19 manifestations, which could serve as potential diagnostic and prognostic biomarkers. This review aimed to discuss the most recent findings on gut microbiota dysbiosis and its relationship with the sequelae of PACS. Elucidating these mechanisms could help develop personalized and non-invasive clinical strategies to identify individuals at a higher risk of experiencing severe disease progression or complications associated with PACS. 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| subjects | B cells Bacteria Coronaviruses COVID-19 Development and progression Dyspnea Health aspects HIV Homeostasis Human immunodeficiency virus Immune system Infections Inflammation Influenza Long COVID Lung diseases Lungs Metabolites Microbiota Microbiota (Symbiotic organisms) Pathogens Remission (Medicine) Review Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral infections Virus diseases Viruses |
| title | Dynamics of the Microbiota and Its Relationship with Post-COVID-19 Syndrome |
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