Standardized Computer-Assisted Analysis of 5-hmC Immunoreactivity in Dysplastic Nevi and Superficial Spreading Melanomas

5-Hydroxymethylcytosine (5-hmC) is an important intermediate of DNA demethylation. Hypomethylation of DNA is frequent in cancer, resulting in deregulation of 5-hmC levels in melanoma. However, the interpretation of the intensity and distribution of 5-hmC immunoreactivity is not very standardized, wh...

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Veröffentlicht in:	International journal of molecular sciences 2023-09, Vol.24 (19), p.14711
Hauptverfasser:	Koch, Elias A T, Berking, Carola, Erber, Ramona, Erdmann, Michael, Kiesewetter, Franklin, Schliep, Stefan, Heppt, Markus V
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biopsy Computers DNA methylation Dysplastic Nevus Syndrome - genetics Dysplastic Nevus Syndrome - pathology Enzymes Epigenetic inheritance Epigenetics Humans Medical prognosis Melanoma Melanoma - pathology Melanoma, Cutaneous Malignant RNA polymerase Skin Skin cancer Skin Neoplasms - pathology Stains & staining
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