Engineered lentivirus-derived nanoparticles (LVNPs) for delivery of CRISPR/Cas ribonucleoprotein complexes supporting base editing, prime editing and in vivo gene modification

Abstract Implementation of therapeutic in vivo gene editing using CRISPR/Cas relies on potent delivery of gene editing tools. Administration of ribonucleoprotein (RNP) complexes consisting of Cas protein and single guide RNA (sgRNA) offers short-lived editing activity and safety advantages over conv...

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Veröffentlicht in:	Nucleic acids research 2023-10, Vol.51 (18), p.10059-10074
Hauptverfasser:	Haldrup, Jakob, Andersen, Sofie, Labial, Alexander Rafael LaVilla, Wolff, Jonas Holst, Frandsen, Frederik Plum, Skov, Thomas Wisbech, Rovsing, Anne Bruun, Nielsen, Ian, Jakobsen, Thomas Stax, Askou, Anne Louise, Thomsen, Martin K, Corydon, Thomas J, Thomsen, Emil Aagaard, Mikkelsen, Jacob Giehm
Format:	Artikel
Sprache:	eng
Schlagworte:	Synthetic Biology and Bioengineering
Online-Zugang:	Volltext
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