Relationship Between Asthma Control Status and Health-Related Quality of Life in Japan: A Cross-Sectional Mixed-Methods Study
Introduction There is limited information regarding multidimensional relationships between asthma control and health-related quality of life (HRQoL), work productivity, and asthma symptom burden in Japan. Furthermore, systematic qualitative investigations about asthma burden have not been performed....
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| Veröffentlicht in: | Advances in therapy 2023-11, Vol.40 (11), p.4857-4876 |
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| creator | Nagase, Hiroyuki Ito, Risako Ishii, Moe Shibata, Hideki Suo, Shintaro Mukai, Isao Zhang, Shiyuan Rothnie, Kieran J. Trennery, Claire Yuanita, Liza Ishii, Takeo |
| description | Introduction
There is limited information regarding multidimensional relationships between asthma control and health-related quality of life (HRQoL), work productivity, and asthma symptom burden in Japan. Furthermore, systematic qualitative investigations about asthma burden have not been performed.
Methods
This cross-sectional, mixed-methods study included Japanese patients (≥ 20 years) with asthma adherent to inhaled corticosteroids/long-acting β
2
-agonists (ICS/LABA). The primary endpoint was impact of asthma on HRQoL, measured using the Asthma Health Questionnaire-33 (AHQ-33). Secondary endpoints were cough burden (Japanese-adapted Leicester Cough Questionnaire [J-LCQ]) and impact of asthma on work/activities (asthma-specific Work Productivity and Activity Impairment Questionnaire [WPAI:Asthma]). Quantitative data were assessed for the overall population and for well-controlled (WC) and not well-controlled (NWC) asthma subgroups. Qualitative verbal interviews further assessed the impact of NWC asthma on patients’ HRQoL; emergent themes were extracted using thematic analyses.
Results
Of 454 patients, 45.2% (
n
= 205) had NWC asthma. Patients with NWC asthma had significantly worse asthma- and cough-related HRQoL across all AHQ-33 and J-LCQ domains and significantly greater work and activity impairment versus patients with WC asthma, across all assessed WPAI:Asthma domains. AHQ-33 total score was highly correlated with J-LCQ total and domain scores (
r
= − 0.8132 to
r
= − 0.7407). Nine themes emerged from qualitative interviews and confirmed that patients with NWC asthma had considerable HRQoL impairment due to asthma symptoms.
Conclusions
Patients with NWC asthma had higher symptom burden and worse HRQoL than patients with WC asthma, despite ICS/LABA adherence. Cough burden correlated with HRQoL, suggesting cough may be one of the key markers to inform treatment strategy for patients with asthma. |
| doi_str_mv | 10.1007/s12325-023-02660-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10567960</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2864156847</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-625c897e1fad0539355767d215f3ef198b895989f1f925d6f3a724fdd8e6a8313</originalsourceid><addsrcrecordid>eNp9kT1vFDEQhi1ERI7AH6BALmkM_lh_LA06TkCILkIQkOgsZz3OOtpbH2svcAX_HV8uRNBQjKaY933GnhehJ4w-Z5TqF5lxwSWhXNRSihJ5Dy2YUZLU4vfRguqGES7M12P0MOdrSjnV0jxAx0Kr1mimF-jXJxhciWnMfdzi11B-AIx4mUu_cXiVxjKlAV8UV-aM3ejxKbih9OTGBR5_nN0Qyw6ngNcxAI4jPnNbN77ES7yaUs7kAro93g34PP4ET86h9Mnnypz97hE6Cm7I8Pi2n6Avb998Xp2S9Yd371fLNemaRheiuOxMq4EF56kUrZBSK-05k0FAYK25NK1sTRtYaLn0KgineRO8N6CcEUycoFcH7na-3IDvoP7LDXY7xY2bdja5aP-djLG3V-m7ZVQq3SpaCc9uCVP6NkMudhNzB8PgRkhzttyohkllGl2l_CDt9geYINztYdTug7OH4GwNzt4EZ2U1Pf37hXeWP0lVgTgIch2NVzDZ6zRP9a75f9jffOClHQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2864156847</pqid></control><display><type>article</type><title>Relationship Between Asthma Control Status and Health-Related Quality of Life in Japan: A Cross-Sectional Mixed-Methods Study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Nagase, Hiroyuki ; Ito, Risako ; Ishii, Moe ; Shibata, Hideki ; Suo, Shintaro ; Mukai, Isao ; Zhang, Shiyuan ; Rothnie, Kieran J. ; Trennery, Claire ; Yuanita, Liza ; Ishii, Takeo</creator><creatorcontrib>Nagase, Hiroyuki ; Ito, Risako ; Ishii, Moe ; Shibata, Hideki ; Suo, Shintaro ; Mukai, Isao ; Zhang, Shiyuan ; Rothnie, Kieran J. ; Trennery, Claire ; Yuanita, Liza ; Ishii, Takeo</creatorcontrib><description>Introduction
There is limited information regarding multidimensional relationships between asthma control and health-related quality of life (HRQoL), work productivity, and asthma symptom burden in Japan. Furthermore, systematic qualitative investigations about asthma burden have not been performed.
Methods
This cross-sectional, mixed-methods study included Japanese patients (≥ 20 years) with asthma adherent to inhaled corticosteroids/long-acting β
2
-agonists (ICS/LABA). The primary endpoint was impact of asthma on HRQoL, measured using the Asthma Health Questionnaire-33 (AHQ-33). Secondary endpoints were cough burden (Japanese-adapted Leicester Cough Questionnaire [J-LCQ]) and impact of asthma on work/activities (asthma-specific Work Productivity and Activity Impairment Questionnaire [WPAI:Asthma]). Quantitative data were assessed for the overall population and for well-controlled (WC) and not well-controlled (NWC) asthma subgroups. Qualitative verbal interviews further assessed the impact of NWC asthma on patients’ HRQoL; emergent themes were extracted using thematic analyses.
Results
Of 454 patients, 45.2% (
n
= 205) had NWC asthma. Patients with NWC asthma had significantly worse asthma- and cough-related HRQoL across all AHQ-33 and J-LCQ domains and significantly greater work and activity impairment versus patients with WC asthma, across all assessed WPAI:Asthma domains. AHQ-33 total score was highly correlated with J-LCQ total and domain scores (
r
= − 0.8132 to
r
= − 0.7407). Nine themes emerged from qualitative interviews and confirmed that patients with NWC asthma had considerable HRQoL impairment due to asthma symptoms.
Conclusions
Patients with NWC asthma had higher symptom burden and worse HRQoL than patients with WC asthma, despite ICS/LABA adherence. Cough burden correlated with HRQoL, suggesting cough may be one of the key markers to inform treatment strategy for patients with asthma.</description><identifier>ISSN: 0741-238X</identifier><identifier>ISSN: 1865-8652</identifier><identifier>EISSN: 1865-8652</identifier><identifier>DOI: 10.1007/s12325-023-02660-5</identifier><identifier>PMID: 37698717</identifier><language>eng</language><publisher>Cheshire: Springer Healthcare</publisher><subject>Administration, Inhalation ; Adrenal Cortex Hormones - therapeutic use ; Asthma - drug therapy ; Cardiology ; Cough - etiology ; Cross-Sectional Studies ; Drug Therapy, Combination ; Endocrinology ; Humans ; Internal Medicine ; Japan ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Pharmacology/Toxicology ; Quality of Life ; Rheumatology</subject><ispartof>Advances in therapy, 2023-11, Vol.40 (11), p.4857-4876</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-625c897e1fad0539355767d215f3ef198b895989f1f925d6f3a724fdd8e6a8313</citedby><cites>FETCH-LOGICAL-c447t-625c897e1fad0539355767d215f3ef198b895989f1f925d6f3a724fdd8e6a8313</cites><orcidid>0000-0001-8523-0419 ; 0000-0001-6865-1967 ; 0000-0002-0296-5901</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12325-023-02660-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12325-023-02660-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37698717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagase, Hiroyuki</creatorcontrib><creatorcontrib>Ito, Risako</creatorcontrib><creatorcontrib>Ishii, Moe</creatorcontrib><creatorcontrib>Shibata, Hideki</creatorcontrib><creatorcontrib>Suo, Shintaro</creatorcontrib><creatorcontrib>Mukai, Isao</creatorcontrib><creatorcontrib>Zhang, Shiyuan</creatorcontrib><creatorcontrib>Rothnie, Kieran J.</creatorcontrib><creatorcontrib>Trennery, Claire</creatorcontrib><creatorcontrib>Yuanita, Liza</creatorcontrib><creatorcontrib>Ishii, Takeo</creatorcontrib><title>Relationship Between Asthma Control Status and Health-Related Quality of Life in Japan: A Cross-Sectional Mixed-Methods Study</title><title>Advances in therapy</title><addtitle>Adv Ther</addtitle><addtitle>Adv Ther</addtitle><description>Introduction
There is limited information regarding multidimensional relationships between asthma control and health-related quality of life (HRQoL), work productivity, and asthma symptom burden in Japan. Furthermore, systematic qualitative investigations about asthma burden have not been performed.
Methods
This cross-sectional, mixed-methods study included Japanese patients (≥ 20 years) with asthma adherent to inhaled corticosteroids/long-acting β
2
-agonists (ICS/LABA). The primary endpoint was impact of asthma on HRQoL, measured using the Asthma Health Questionnaire-33 (AHQ-33). Secondary endpoints were cough burden (Japanese-adapted Leicester Cough Questionnaire [J-LCQ]) and impact of asthma on work/activities (asthma-specific Work Productivity and Activity Impairment Questionnaire [WPAI:Asthma]). Quantitative data were assessed for the overall population and for well-controlled (WC) and not well-controlled (NWC) asthma subgroups. Qualitative verbal interviews further assessed the impact of NWC asthma on patients’ HRQoL; emergent themes were extracted using thematic analyses.
Results
Of 454 patients, 45.2% (
n
= 205) had NWC asthma. Patients with NWC asthma had significantly worse asthma- and cough-related HRQoL across all AHQ-33 and J-LCQ domains and significantly greater work and activity impairment versus patients with WC asthma, across all assessed WPAI:Asthma domains. AHQ-33 total score was highly correlated with J-LCQ total and domain scores (
r
= − 0.8132 to
r
= − 0.7407). Nine themes emerged from qualitative interviews and confirmed that patients with NWC asthma had considerable HRQoL impairment due to asthma symptoms.
Conclusions
Patients with NWC asthma had higher symptom burden and worse HRQoL than patients with WC asthma, despite ICS/LABA adherence. Cough burden correlated with HRQoL, suggesting cough may be one of the key markers to inform treatment strategy for patients with asthma.</description><subject>Administration, Inhalation</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Asthma - drug therapy</subject><subject>Cardiology</subject><subject>Cough - etiology</subject><subject>Cross-Sectional Studies</subject><subject>Drug Therapy, Combination</subject><subject>Endocrinology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Japan</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><subject>Quality of Life</subject><subject>Rheumatology</subject><issn>0741-238X</issn><issn>1865-8652</issn><issn>1865-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kT1vFDEQhi1ERI7AH6BALmkM_lh_LA06TkCILkIQkOgsZz3OOtpbH2svcAX_HV8uRNBQjKaY933GnhehJ4w-Z5TqF5lxwSWhXNRSihJ5Dy2YUZLU4vfRguqGES7M12P0MOdrSjnV0jxAx0Kr1mimF-jXJxhciWnMfdzi11B-AIx4mUu_cXiVxjKlAV8UV-aM3ejxKbih9OTGBR5_nN0Qyw6ngNcxAI4jPnNbN77ES7yaUs7kAro93g34PP4ET86h9Mnnypz97hE6Cm7I8Pi2n6Avb998Xp2S9Yd371fLNemaRheiuOxMq4EF56kUrZBSK-05k0FAYK25NK1sTRtYaLn0KgineRO8N6CcEUycoFcH7na-3IDvoP7LDXY7xY2bdja5aP-djLG3V-m7ZVQq3SpaCc9uCVP6NkMudhNzB8PgRkhzttyohkllGl2l_CDt9geYINztYdTug7OH4GwNzt4EZ2U1Pf37hXeWP0lVgTgIch2NVzDZ6zRP9a75f9jffOClHQ</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Nagase, Hiroyuki</creator><creator>Ito, Risako</creator><creator>Ishii, Moe</creator><creator>Shibata, Hideki</creator><creator>Suo, Shintaro</creator><creator>Mukai, Isao</creator><creator>Zhang, Shiyuan</creator><creator>Rothnie, Kieran J.</creator><creator>Trennery, Claire</creator><creator>Yuanita, Liza</creator><creator>Ishii, Takeo</creator><general>Springer Healthcare</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8523-0419</orcidid><orcidid>https://orcid.org/0000-0001-6865-1967</orcidid><orcidid>https://orcid.org/0000-0002-0296-5901</orcidid></search><sort><creationdate>20231101</creationdate><title>Relationship Between Asthma Control Status and Health-Related Quality of Life in Japan: A Cross-Sectional Mixed-Methods Study</title><author>Nagase, Hiroyuki ; Ito, Risako ; Ishii, Moe ; Shibata, Hideki ; Suo, Shintaro ; Mukai, Isao ; Zhang, Shiyuan ; Rothnie, Kieran J. ; Trennery, Claire ; Yuanita, Liza ; Ishii, Takeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-625c897e1fad0539355767d215f3ef198b895989f1f925d6f3a724fdd8e6a8313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Administration, Inhalation</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Asthma - drug therapy</topic><topic>Cardiology</topic><topic>Cough - etiology</topic><topic>Cross-Sectional Studies</topic><topic>Drug Therapy, Combination</topic><topic>Endocrinology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Japan</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><topic>Quality of Life</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagase, Hiroyuki</creatorcontrib><creatorcontrib>Ito, Risako</creatorcontrib><creatorcontrib>Ishii, Moe</creatorcontrib><creatorcontrib>Shibata, Hideki</creatorcontrib><creatorcontrib>Suo, Shintaro</creatorcontrib><creatorcontrib>Mukai, Isao</creatorcontrib><creatorcontrib>Zhang, Shiyuan</creatorcontrib><creatorcontrib>Rothnie, Kieran J.</creatorcontrib><creatorcontrib>Trennery, Claire</creatorcontrib><creatorcontrib>Yuanita, Liza</creatorcontrib><creatorcontrib>Ishii, Takeo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advances in therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagase, Hiroyuki</au><au>Ito, Risako</au><au>Ishii, Moe</au><au>Shibata, Hideki</au><au>Suo, Shintaro</au><au>Mukai, Isao</au><au>Zhang, Shiyuan</au><au>Rothnie, Kieran J.</au><au>Trennery, Claire</au><au>Yuanita, Liza</au><au>Ishii, Takeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Asthma Control Status and Health-Related Quality of Life in Japan: A Cross-Sectional Mixed-Methods Study</atitle><jtitle>Advances in therapy</jtitle><stitle>Adv Ther</stitle><addtitle>Adv Ther</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>40</volume><issue>11</issue><spage>4857</spage><epage>4876</epage><pages>4857-4876</pages><issn>0741-238X</issn><issn>1865-8652</issn><eissn>1865-8652</eissn><abstract>Introduction
There is limited information regarding multidimensional relationships between asthma control and health-related quality of life (HRQoL), work productivity, and asthma symptom burden in Japan. Furthermore, systematic qualitative investigations about asthma burden have not been performed.
Methods
This cross-sectional, mixed-methods study included Japanese patients (≥ 20 years) with asthma adherent to inhaled corticosteroids/long-acting β
2
-agonists (ICS/LABA). The primary endpoint was impact of asthma on HRQoL, measured using the Asthma Health Questionnaire-33 (AHQ-33). Secondary endpoints were cough burden (Japanese-adapted Leicester Cough Questionnaire [J-LCQ]) and impact of asthma on work/activities (asthma-specific Work Productivity and Activity Impairment Questionnaire [WPAI:Asthma]). Quantitative data were assessed for the overall population and for well-controlled (WC) and not well-controlled (NWC) asthma subgroups. Qualitative verbal interviews further assessed the impact of NWC asthma on patients’ HRQoL; emergent themes were extracted using thematic analyses.
Results
Of 454 patients, 45.2% (
n
= 205) had NWC asthma. Patients with NWC asthma had significantly worse asthma- and cough-related HRQoL across all AHQ-33 and J-LCQ domains and significantly greater work and activity impairment versus patients with WC asthma, across all assessed WPAI:Asthma domains. AHQ-33 total score was highly correlated with J-LCQ total and domain scores (
r
= − 0.8132 to
r
= − 0.7407). Nine themes emerged from qualitative interviews and confirmed that patients with NWC asthma had considerable HRQoL impairment due to asthma symptoms.
Conclusions
Patients with NWC asthma had higher symptom burden and worse HRQoL than patients with WC asthma, despite ICS/LABA adherence. Cough burden correlated with HRQoL, suggesting cough may be one of the key markers to inform treatment strategy for patients with asthma.</abstract><cop>Cheshire</cop><pub>Springer Healthcare</pub><pmid>37698717</pmid><doi>10.1007/s12325-023-02660-5</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0001-8523-0419</orcidid><orcidid>https://orcid.org/0000-0001-6865-1967</orcidid><orcidid>https://orcid.org/0000-0002-0296-5901</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Advances in therapy, 2023-11, Vol.40 (11), p.4857-4876 |
| issn | 0741-238X 1865-8652 1865-8652 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Administration, Inhalation Adrenal Cortex Hormones - therapeutic use Asthma - drug therapy Cardiology Cough - etiology Cross-Sectional Studies Drug Therapy, Combination Endocrinology Humans Internal Medicine Japan Medicine Medicine & Public Health Oncology Original Research Pharmacology/Toxicology Quality of Life Rheumatology |
| title | Relationship Between Asthma Control Status and Health-Related Quality of Life in Japan: A Cross-Sectional Mixed-Methods Study |
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