Design and testing of a humanized porcine donor for xenotransplantation

Recent human decedent model studies 1 , 2 and compassionate xenograft use 3 have explored the promise of porcine organs for human transplantation. To proceed to human studies, a clinically ready porcine donor must be engineered and its xenograft successfully tested in nonhuman primates. Here we desc...

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Veröffentlicht in:	Nature (London) 2023-10, Vol.622 (7982), p.393-401
Hauptverfasser:	Anand, Ranjith P., Layer, Jacob V., Heja, David, Hirose, Takayuki, Lassiter, Grace, Firl, Daniel J., Paragas, Violette B., Akkad, Adam, Chhangawala, Sagar, Colvin, Robert B., Ernst, Russell J., Esch, Nicholas, Getchell, Kristen, Griffin, Alexandra K., Guo, Xiaoyun, Hall, Katherine C., Hamilton, Paula, Kalekar, Lokesh A., Kan, Yinan, Karadagi, Ahmad, Li, Feng, Low, Susan C., Matheson, Rudy, Nehring, Claudia, Otsuka, Ryo, Pandelakis, Matthew, Policastro, Robert A., Pols, Rebecca, Queiroz, Luis, Rosales, Ivy A., Serkin, William T., Stiede, Kathryn, Tomosugi, Toshihide, Xue, Yongqiang, Zentner, Gabriel E., Angeles-Albores, David, Chris Chao, J., Crabtree, Juliet N., Harken, Sierra, Hinkle, Nicole, Lemos, Tania, Li, Mailin, Pantano, Lorena, Stevens, Denise, Subedar, Omar D., Tan, Xiaoqing, Yin, Shiyi, Anwar, Imran J., Aufhauser, David, Capuano, Saverio, Kaufman, Dixon B., Knechtle, Stuart J., Kwun, Jean, Shanmuganayagam, Dhanansayan, Markmann, James F., Church, George M., Curtis, Mike, Kawai, Tatsuo, Youd, Michele E., Qin, Wenning
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/107 13/31 13/44 13/51 38/22 38/35 45/23 45/41 45/91 631/61/338/552 692/308/2778 Animals Animals, Genetically Modified Antibodies Antigens Biocompatibility Biopsy Clinical trials CRISPR Endogenous retroviruses Endothelial cells Endothelial Cells - immunology Endothelial Cells - metabolism Genes Genetic engineering Genomes Glycan Graft Rejection - immunology Graft Rejection - prevention & control Hogs Humanities and Social Sciences Humans In vivo methods and tests Inflammation Kidney transplantation Kidney Transplantation - methods Kidneys Macaca fascicularis Monkeys Monkeys & apes multidisciplinary Polysaccharides - deficiency Primates Proteins Science Science (multidisciplinary) Survival Swine - genetics Transgenes Transgenes - genetics Transplantation, Heterologous - methods Transplants & implants Xenografts Xenotransplantation
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