An Adult With Undifferentiated Embryonal Sarcoma of the Liver: A Case Report of a Rare Encounter
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare, aggressive tumor mainly found in children but can also appear in adults. Its diagnosis in adults remains a conundrum; it is often identified late due to its non-specific symptoms and resemblance to benign lesions. A comprehensive trea...
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description | Undifferentiated embryonal sarcoma of the liver (UESL) is a rare, aggressive tumor mainly found in children but can also appear in adults. Its diagnosis in adults remains a conundrum; it is often identified late due to its non-specific symptoms and resemblance to benign lesions. A comprehensive treatment regimen involving surgical intervention, chemotherapy, and possibly radiation significantly boosts survival rates. Imaging often yields inconclusive outcomes, further complicating the diagnostic process.Here, we report the case of a 28-year-old female diagnosed with UESL, emphasizing the need for timely intervention. Undifferentiated embryonal sarcoma of the liver requires differentiation from a variety of hepatic tumors in adults. Though there are no distinctive characteristics to differentiate UESL from other hepatic masses, its morphology and immunohistochemical profiles significantly vary. The staging often reveals UESL as a large, well-defined mass with the potential for diverse differentiation. Its prognosis has been considerably improved with the advent of multidisciplinary treatment. Surgical resection remains a cornerstone, often combined with chemotherapy. While pediatric cases exhibit better overall survival rates than adults, outcomes heavily depend on the chosen treatment regimen. A combination of chemotherapy and complete tumor removal has been found to significantly elevate survival chances.Disease recurrence remains a challenge and is influenced by treatment strategy. In conclusion, the diagnosis and treatment of UESL are fraught with challenges, particularly in adults. A multidimensional approach, combining various therapies, is paramount for better outcomes. Continuous research and enhanced awareness are crucial for improving diagnostic precision and treatment outcomes for UESL patients. |
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Its diagnosis in adults remains a conundrum; it is often identified late due to its non-specific symptoms and resemblance to benign lesions. A comprehensive treatment regimen involving surgical intervention, chemotherapy, and possibly radiation significantly boosts survival rates. Imaging often yields inconclusive outcomes, further complicating the diagnostic process.Here, we report the case of a 28-year-old female diagnosed with UESL, emphasizing the need for timely intervention. Undifferentiated embryonal sarcoma of the liver requires differentiation from a variety of hepatic tumors in adults. Though there are no distinctive characteristics to differentiate UESL from other hepatic masses, its morphology and immunohistochemical profiles significantly vary. The staging often reveals UESL as a large, well-defined mass with the potential for diverse differentiation. Its prognosis has been considerably improved with the advent of multidisciplinary treatment. Surgical resection remains a cornerstone, often combined with chemotherapy. While pediatric cases exhibit better overall survival rates than adults, outcomes heavily depend on the chosen treatment regimen. A combination of chemotherapy and complete tumor removal has been found to significantly elevate survival chances.Disease recurrence remains a challenge and is influenced by treatment strategy. In conclusion, the diagnosis and treatment of UESL are fraught with challenges, particularly in adults. A multidimensional approach, combining various therapies, is paramount for better outcomes. Continuous research and enhanced awareness are crucial for improving diagnostic precision and treatment outcomes for UESL patients.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.45018</identifier><language>eng</language><publisher>Palo Alto: Cureus Inc</publisher><subject>Abdomen ; Abscesses ; Case reports ; Chemotherapy ; Gastroenterology ; General Surgery ; Liver ; Liver cancer ; Medical prognosis ; Metastasis ; Mutation ; Oncology ; Patients ; Pediatrics ; Radiation ; Sarcoma ; Surgery ; Telomerase ; Tumors</subject><ispartof>Curēus (Palo Alto, CA), 2023-09, Vol.15 (9)</ispartof><rights>Copyright © 2023, Rammohan et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Rammohan et al. 2023 Rammohan et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c244t-4383af68d67357a0eb85adfbe6145c45f3addf14ca62cf6ef564b890c46f5593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565881/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565881/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Rammohan, Rajmohan</creatorcontrib><creatorcontrib>Joy, Melvin</creatorcontrib><creatorcontrib>Magam, Sai Greeshma</creatorcontrib><creatorcontrib>Patel, Achal</creatorcontrib><creatorcontrib>Magam, Sai Reshma</creatorcontrib><creatorcontrib>Natt, Dilman</creatorcontrib><creatorcontrib>Desai, Jiten</creatorcontrib><creatorcontrib>Bunting, Susan</creatorcontrib><creatorcontrib>Mustacchia, Paul</creatorcontrib><title>An Adult With Undifferentiated Embryonal Sarcoma of the Liver: A Case Report of a Rare Encounter</title><title>Curēus (Palo Alto, CA)</title><description>Undifferentiated embryonal sarcoma of the liver (UESL) is a rare, aggressive tumor mainly found in children but can also appear in adults. Its diagnosis in adults remains a conundrum; it is often identified late due to its non-specific symptoms and resemblance to benign lesions. A comprehensive treatment regimen involving surgical intervention, chemotherapy, and possibly radiation significantly boosts survival rates. Imaging often yields inconclusive outcomes, further complicating the diagnostic process.Here, we report the case of a 28-year-old female diagnosed with UESL, emphasizing the need for timely intervention. Undifferentiated embryonal sarcoma of the liver requires differentiation from a variety of hepatic tumors in adults. Though there are no distinctive characteristics to differentiate UESL from other hepatic masses, its morphology and immunohistochemical profiles significantly vary. The staging often reveals UESL as a large, well-defined mass with the potential for diverse differentiation. Its prognosis has been considerably improved with the advent of multidisciplinary treatment. Surgical resection remains a cornerstone, often combined with chemotherapy. While pediatric cases exhibit better overall survival rates than adults, outcomes heavily depend on the chosen treatment regimen. A combination of chemotherapy and complete tumor removal has been found to significantly elevate survival chances.Disease recurrence remains a challenge and is influenced by treatment strategy. In conclusion, the diagnosis and treatment of UESL are fraught with challenges, particularly in adults. A multidimensional approach, combining various therapies, is paramount for better outcomes. Continuous research and enhanced awareness are crucial for improving diagnostic precision and treatment outcomes for UESL patients.</description><subject>Abdomen</subject><subject>Abscesses</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Gastroenterology</subject><subject>General Surgery</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Radiation</subject><subject>Sarcoma</subject><subject>Surgery</subject><subject>Telomerase</subject><subject>Tumors</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpVkV9LwzAUxYMoOObe_AABX-1M2iTNfJEx5h8YCHPiY0zTG9fRNjNJB_v2dk5En-6Fc_jdezgIXVIyznM-uTGdhy6MGSdUnqBBSoVMJJXs9M9-jkYhbAghlOQpyckAvU9bPC27OuK3Kq7xa1tW1oKHNlY6QonnTeH3rtU1ftHeuEZjZ3FcA15UO_C3eIpnOgBewtb5eNA0XmoPeN4a17UR_AU6s7oOMPqZQ7S6n69mj8ni-eFpNl0kJmUsJiyTmbZCliLPeK4JFJLr0hYgKOOGcZvpsrSUGS1SYwVYLlghJ8QwYTmfZEN0d8Ruu6KB0vQBvK7V1leN9nvldKX-K221Vh9upyjhgktJe8LVD8G7zw5CVBvX-T55UKmUjPePZHnvuj66jHcheLC_JyhRhx7UsQf13UP2BRigfUs</recordid><startdate>20230911</startdate><enddate>20230911</enddate><creator>Rammohan, Rajmohan</creator><creator>Joy, Melvin</creator><creator>Magam, Sai Greeshma</creator><creator>Patel, Achal</creator><creator>Magam, Sai Reshma</creator><creator>Natt, Dilman</creator><creator>Desai, Jiten</creator><creator>Bunting, Susan</creator><creator>Mustacchia, Paul</creator><general>Cureus Inc</general><general>Cureus</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20230911</creationdate><title>An Adult With Undifferentiated Embryonal Sarcoma of the Liver: A Case Report of a Rare Encounter</title><author>Rammohan, Rajmohan ; 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Its diagnosis in adults remains a conundrum; it is often identified late due to its non-specific symptoms and resemblance to benign lesions. A comprehensive treatment regimen involving surgical intervention, chemotherapy, and possibly radiation significantly boosts survival rates. Imaging often yields inconclusive outcomes, further complicating the diagnostic process.Here, we report the case of a 28-year-old female diagnosed with UESL, emphasizing the need for timely intervention. Undifferentiated embryonal sarcoma of the liver requires differentiation from a variety of hepatic tumors in adults. Though there are no distinctive characteristics to differentiate UESL from other hepatic masses, its morphology and immunohistochemical profiles significantly vary. The staging often reveals UESL as a large, well-defined mass with the potential for diverse differentiation. Its prognosis has been considerably improved with the advent of multidisciplinary treatment. Surgical resection remains a cornerstone, often combined with chemotherapy. While pediatric cases exhibit better overall survival rates than adults, outcomes heavily depend on the chosen treatment regimen. A combination of chemotherapy and complete tumor removal has been found to significantly elevate survival chances.Disease recurrence remains a challenge and is influenced by treatment strategy. In conclusion, the diagnosis and treatment of UESL are fraught with challenges, particularly in adults. A multidimensional approach, combining various therapies, is paramount for better outcomes. Continuous research and enhanced awareness are crucial for improving diagnostic precision and treatment outcomes for UESL patients.</abstract><cop>Palo Alto</cop><pub>Cureus Inc</pub><doi>10.7759/cureus.45018</doi><oa>free_for_read</oa></addata></record> |
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subjects | Abdomen Abscesses Case reports Chemotherapy Gastroenterology General Surgery Liver Liver cancer Medical prognosis Metastasis Mutation Oncology Patients Pediatrics Radiation Sarcoma Surgery Telomerase Tumors |
title | An Adult With Undifferentiated Embryonal Sarcoma of the Liver: A Case Report of a Rare Encounter |
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