Cytokinin antagonist activity of substituted phenethylamines in plant cell culture
A series of structurally related substituted phenethylamines shows extreme toxicity toward wild-type callus tissue cultures of tobacco (Nicotiana tabacum), soybean (Glycine max), corn (Zea mays), and sunflower (Helianthus annuus L.), but tobacco crown gall cultures are resistant to the compounds. Th...
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| Veröffentlicht in: | Plant physiology (Bethesda) 1989-02, Vol.89 (2), p.564-568 |
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| creator | Christou, P Barton, K.A |
| description | A series of structurally related substituted phenethylamines shows extreme toxicity toward wild-type callus tissue cultures of tobacco (Nicotiana tabacum), soybean (Glycine max), corn (Zea mays), and sunflower (Helianthus annuus L.), but tobacco crown gall cultures are resistant to the compounds. The essential components that result in toxicity of the phenethylamines include one aromatic hydroxyl and one primary aliphatic amino group. A series of attenuated crown gall cultures, generated by transformation of tobacco with various modified Agrobacterium strains, has been used to demonstrate that the resistance of crown galls to the phenethylamines is due to the expression in these tissues of isopentenyl transferase, a first step in cytokinin biosynthesis. The toxicity of the compounds to tissue cultures is very rapid, but can be overcome by prior exposure of the calli to exogenous cytokinin. Because of the relationships we have observed between cytokinins and these compounds, we propose that the substituted phenethylamines may represent a class of chemicals that can be used as specific probes to further an understanding of cytokinin metabolism in plant tissues |
| doi_str_mv | 10.1104/pp.89.2.564 |
| format | Article |
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The essential components that result in toxicity of the phenethylamines include one aromatic hydroxyl and one primary aliphatic amino group. A series of attenuated crown gall cultures, generated by transformation of tobacco with various modified Agrobacterium strains, has been used to demonstrate that the resistance of crown galls to the phenethylamines is due to the expression in these tissues of isopentenyl transferase, a first step in cytokinin biosynthesis. The toxicity of the compounds to tissue cultures is very rapid, but can be overcome by prior exposure of the calli to exogenous cytokinin. Because of the relationships we have observed between cytokinins and these compounds, we propose that the substituted phenethylamines may represent a class of chemicals that can be used as specific probes to further an understanding of cytokinin metabolism in plant tissues</description><identifier>ISSN: 0032-0889</identifier><identifier>EISSN: 1532-2548</identifier><identifier>DOI: 10.1104/pp.89.2.564</identifier><identifier>PMID: 16666583</identifier><identifier>CODEN: PPHYA5</identifier><language>eng</language><publisher>Rockville, MD: American Society of Plant Physiologists</publisher><subject>Agrobacterium ; AMINAS ; AMINE ; Auxins ; Biological and medical sciences ; BIOSINTESIS ; BIOSYNTHESE ; Biosynthesis ; Biotechnology ; Callus ; Catecholamines ; CITOCININAS ; CULTIVO DE CELULAS ; CULTURE DE CELLULES ; Cultured cells ; CYTOKININE ; Cytokinins ; Eukaryotic cell cultures ; Fundamental and applied biological sciences. Psychology ; GLYCINE MAX ; GOSSYPIUM HIRSUTUM ; HELIANTHUS ANNUUS ; In vitro propagation: entire plant regeneration from tissues and cell cultures ; METABOLISME ; METABOLISMO ; Methods. Procedures. Technologies ; Molecular Biology and Gene Regulation ; NICOTIANA TABACUM ; Phenethylamines ; Plant cells ; Plant cells and fungal cells ; Plant gall ; Plant physiology and development ; Tissue cultures, protoplasts ; ZEA MAYS</subject><ispartof>Plant physiology (Bethesda), 1989-02, Vol.89 (2), p.564-568</ispartof><rights>Copyright 1989 American Society of Plant Physiologists</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-d5eb2162097e7a304e0e3aadfedc0295f3e9f312434d27b0f6cc9ed533ef61443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4271875$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4271875$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6792190$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16666583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christou, P</creatorcontrib><creatorcontrib>Barton, K.A</creatorcontrib><title>Cytokinin antagonist activity of substituted phenethylamines in plant cell culture</title><title>Plant physiology (Bethesda)</title><addtitle>Plant Physiol</addtitle><description>A series of structurally related substituted phenethylamines shows extreme toxicity toward wild-type callus tissue cultures of tobacco (Nicotiana tabacum), soybean (Glycine max), corn (Zea mays), and sunflower (Helianthus annuus L.), but tobacco crown gall cultures are resistant to the compounds. The essential components that result in toxicity of the phenethylamines include one aromatic hydroxyl and one primary aliphatic amino group. A series of attenuated crown gall cultures, generated by transformation of tobacco with various modified Agrobacterium strains, has been used to demonstrate that the resistance of crown galls to the phenethylamines is due to the expression in these tissues of isopentenyl transferase, a first step in cytokinin biosynthesis. The toxicity of the compounds to tissue cultures is very rapid, but can be overcome by prior exposure of the calli to exogenous cytokinin. Because of the relationships we have observed between cytokinins and these compounds, we propose that the substituted phenethylamines may represent a class of chemicals that can be used as specific probes to further an understanding of cytokinin metabolism in plant tissues</description><subject>Agrobacterium</subject><subject>AMINAS</subject><subject>AMINE</subject><subject>Auxins</subject><subject>Biological and medical sciences</subject><subject>BIOSINTESIS</subject><subject>BIOSYNTHESE</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Callus</subject><subject>Catecholamines</subject><subject>CITOCININAS</subject><subject>CULTIVO DE CELULAS</subject><subject>CULTURE DE CELLULES</subject><subject>Cultured cells</subject><subject>CYTOKININE</subject><subject>Cytokinins</subject><subject>Eukaryotic cell cultures</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLYCINE MAX</subject><subject>GOSSYPIUM HIRSUTUM</subject><subject>HELIANTHUS ANNUUS</subject><subject>In vitro propagation: entire plant regeneration from tissues and cell cultures</subject><subject>METABOLISME</subject><subject>METABOLISMO</subject><subject>Methods. Procedures. Technologies</subject><subject>Molecular Biology and Gene Regulation</subject><subject>NICOTIANA TABACUM</subject><subject>Phenethylamines</subject><subject>Plant cells</subject><subject>Plant cells and fungal cells</subject><subject>Plant gall</subject><subject>Plant physiology and development</subject><subject>Tissue cultures, protoplasts</subject><subject>ZEA MAYS</subject><issn>0032-0889</issn><issn>1532-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNpVkc1rGzEQxUVoSZykp9xCKHsI9FDs6nNXuhSK6RcECmlzFrJ2ZCtdS1tJG_B_XwUbN9VlBO_33kgzCF0RvCAE8w_juJBqQRei5SdoRgSjcyq4fIVmGNc7llKdofOcHzHGhBF-is5IW4-QbIbul7sSf_vgQ2NCMesYfC6NscU_-bJromvytMrFl6lA34wbCFA2u8FsfYDcVNc4VF9jYRgaOw1lSnCJXjszZHhzqBfo4cvnX8tv87sfX78vP93NLSe8zHsBK0pailUHnWGYAwZmTO-gt5gq4RgoxwjljPe0W2HXWqugF4yBawnn7AJ93OeO02pbTRBKMoMek9-atNPReP2_EvxGr-OTJlgIKWkNeHcISPHPBLnorc_PPzEB4pR1xxhXQghVyfd70qaYcwJ37EKwfl6CHkctlaa6LqHSb18-7B97mHoFbg-AydYMLplgfT5ybacoUbhiN3vsMZeYjjKnHZGdqPL1XnYmarNONeHhp1SUESzZX6sIo7M</recordid><startdate>19890201</startdate><enddate>19890201</enddate><creator>Christou, P</creator><creator>Barton, K.A</creator><general>American Society of Plant Physiologists</general><scope>FBQ</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890201</creationdate><title>Cytokinin antagonist activity of substituted phenethylamines in plant cell culture</title><author>Christou, P ; Barton, K.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-d5eb2162097e7a304e0e3aadfedc0295f3e9f312434d27b0f6cc9ed533ef61443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Agrobacterium</topic><topic>AMINAS</topic><topic>AMINE</topic><topic>Auxins</topic><topic>Biological and medical sciences</topic><topic>BIOSINTESIS</topic><topic>BIOSYNTHESE</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Callus</topic><topic>Catecholamines</topic><topic>CITOCININAS</topic><topic>CULTIVO DE CELULAS</topic><topic>CULTURE DE CELLULES</topic><topic>Cultured cells</topic><topic>CYTOKININE</topic><topic>Cytokinins</topic><topic>Eukaryotic cell cultures</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLYCINE MAX</topic><topic>GOSSYPIUM HIRSUTUM</topic><topic>HELIANTHUS ANNUUS</topic><topic>In vitro propagation: entire plant regeneration from tissues and cell cultures</topic><topic>METABOLISME</topic><topic>METABOLISMO</topic><topic>Methods. Procedures. Technologies</topic><topic>Molecular Biology and Gene Regulation</topic><topic>NICOTIANA TABACUM</topic><topic>Phenethylamines</topic><topic>Plant cells</topic><topic>Plant cells and fungal cells</topic><topic>Plant gall</topic><topic>Plant physiology and development</topic><topic>Tissue cultures, protoplasts</topic><topic>ZEA MAYS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christou, P</creatorcontrib><creatorcontrib>Barton, K.A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Plant physiology (Bethesda)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christou, P</au><au>Barton, K.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokinin antagonist activity of substituted phenethylamines in plant cell culture</atitle><jtitle>Plant physiology (Bethesda)</jtitle><addtitle>Plant Physiol</addtitle><date>1989-02-01</date><risdate>1989</risdate><volume>89</volume><issue>2</issue><spage>564</spage><epage>568</epage><pages>564-568</pages><issn>0032-0889</issn><eissn>1532-2548</eissn><coden>PPHYA5</coden><abstract>A series of structurally related substituted phenethylamines shows extreme toxicity toward wild-type callus tissue cultures of tobacco (Nicotiana tabacum), soybean (Glycine max), corn (Zea mays), and sunflower (Helianthus annuus L.), but tobacco crown gall cultures are resistant to the compounds. The essential components that result in toxicity of the phenethylamines include one aromatic hydroxyl and one primary aliphatic amino group. A series of attenuated crown gall cultures, generated by transformation of tobacco with various modified Agrobacterium strains, has been used to demonstrate that the resistance of crown galls to the phenethylamines is due to the expression in these tissues of isopentenyl transferase, a first step in cytokinin biosynthesis. The toxicity of the compounds to tissue cultures is very rapid, but can be overcome by prior exposure of the calli to exogenous cytokinin. Because of the relationships we have observed between cytokinins and these compounds, we propose that the substituted phenethylamines may represent a class of chemicals that can be used as specific probes to further an understanding of cytokinin metabolism in plant tissues</abstract><cop>Rockville, MD</cop><pub>American Society of Plant Physiologists</pub><pmid>16666583</pmid><doi>10.1104/pp.89.2.564</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Jstor Complete Legacy; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Agrobacterium AMINAS AMINE Auxins Biological and medical sciences BIOSINTESIS BIOSYNTHESE Biosynthesis Biotechnology Callus Catecholamines CITOCININAS CULTIVO DE CELULAS CULTURE DE CELLULES Cultured cells CYTOKININE Cytokinins Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology GLYCINE MAX GOSSYPIUM HIRSUTUM HELIANTHUS ANNUUS In vitro propagation: entire plant regeneration from tissues and cell cultures METABOLISME METABOLISMO Methods. Procedures. Technologies Molecular Biology and Gene Regulation NICOTIANA TABACUM Phenethylamines Plant cells Plant cells and fungal cells Plant gall Plant physiology and development Tissue cultures, protoplasts ZEA MAYS |
| title | Cytokinin antagonist activity of substituted phenethylamines in plant cell culture |
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