THU272 Early Time Restricted Feeding As a Weight Neutral Approach To Improved Glycemic Variation

Disclosure: S. Nasserifar: None. J. Bruno: None. S. Vanegas: None. C. Popp: None. J.M. Walker: None. J.O. Aleman Diaz: None. Abstract: Early time-restricted feeding (eTRF) is a type of intermittent fasting that involves restricting caloric intake to the first 6-8 hours of the day. Various studies suggest that eTRF improves cardiometabolic health and glycemic variation. However, it is unclear whether these effects are a consequence of weight loss that frequently accompanies this dietary intervention or due to the metabolic effects of the feeding strategy itself. To address this, we conducted a randomized 7-day isocaloric crossover supervised feeding study comparing eTRF (80% of calories consumed before 1 pm) to a usual feeding pattern (UFP, 50% of calories consumed after 4 pm) among 10 participants with prediabetes and obesity in a metabolic ward. Participants were randomized 1:1 to eTRF or UFP for days 1-7, and then subsequently crossed over to the alternate arm on days 8-14. In order to determine the weight-independent effects of this intervention, food was provided to meet participants’ calculated caloric needs for weight maintenance. To assess glycemia, continuous glucose monitoring was utilized throughout the study period and OGTTs were performed at baseline, crossover point (day 7), and at the end of the study (day 14). Subjects’ weights were stable across the study duration. Compared to the control (UFP), eTRF resulted in decreased mean amplitude of glycemic excursion (MAGE) of 2.5 mmol/L ± 0.2 vs 2.9 mmol/L ± 0.3 (p