Metastasis and immunosuppression promoted by mtDNA and PD-L1 in extracellular vesicles are reversed by WGP β-glucan in oral squamous cell carcinoma

The suppressive regulatory T cells (Treg) are frequently upregulated in cancer patients. This study aims to demonstrate the hypothesis that arecoline could induce the secretion of mitochondrial (mt) DNA D-loop and programmed cell death-ligand 1 (PD-L1) in extracellular vesicles (EVs), and attenuate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2023-10, Vol.114 (10), p.3857-3872
Hauptverfasser:	Ko, Hui-Hsin, Peng, Hsin-Hui, Cheng, An Ning, Chou, Han-Yi Elizabeth, Hou, Hsin-Han, Kuo, Wei-Ting, Liu, Wei-Wen, Kuo, Mark Yen-Ping, Lee, Alan Yueh-Luen, Cheng, Shih-Jung
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer therapies CD4 antigen CD8 antigen Cell death Cells Drug resistance Extracellular vesicles Immunity Immunoregulation Immunosuppression Lymphocytes T Metastases Metastasis Mitochondrial DNA Multivariate analysis Oral carcinoma Oral squamous cell carcinoma Original ORIGINAL ARTICLES Oxidative stress PD-L1 protein Reactive oxygen species β-Glucan γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!