Epidemiology and molecular typing of multidrug-resistant bacteria in day care centres in Flanders, Belgium
The global prevalence and spread of multidrug-resistant organisms (MDROs) represent an emerging public health threat. Day care centre (DCC) attendance is a risk factor for MDRO carriage in children and their environment. This study aimed to map the epidemiology of carriage and potential transmission...
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| Veröffentlicht in: | Epidemiology and infection 2023-09, Vol.151, Article e156 |
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| creator | van Kleef – van Koeveringe, Stefanie Matheeussen, Veerle Jansens, Hilde Perales Selva, Natascha De Coninck, Dieter De Bruyne, Katrien Mensaert, Klaas Kluytmans - van den Bergh, Marjolein Kluytmans, Jan Goossens, Herman Dhaeze, Wouter |
| description | The global prevalence and spread of multidrug-resistant organisms (MDROs) represent an emerging public health threat. Day care centre (DCC) attendance is a risk factor for MDRO carriage in children and their environment. This study aimed to map the epidemiology of carriage and potential transmission of these organisms within 18 Flemish DDCs (Belgium). An MDRO prevalence survey was organised between November 2018 and February 2019 among children attending the centres. Selective chromogenic culture media were used for the detection of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenemase-producing Enterobacterales (CPE), and vancomycin-resistant Enterococci (VRE) in faecal swabs obtained from diapers or jars (n = 448). All isolated MDROs were subjected to resistance gene sequencing. A total of 71 of 448 samples (15.8%) yielded isolates of ESBL-E with a predominance of Escherichia coli (92.2% of ESBL-E) and ESBL resistance gene blaCTX-M-15 (50.7% of ESBL coding genes in E. coli). ESBL-E prevalence varied between DCCs, ranging from 0 to 50%. Transmission, based on the clonal relatedness of ESBL-E strains, was observed. CPE was identified in only one child carrying an E. coli with an OXA-244 gene. VRE was absent from all samples. The observed prevalence of ESBL-E in Flemish DCCs is high compared with previous studies, and our findings re-emphasise the need for rigorous hygiene measures within such centres to control the further spread of MDROs in the community. |
| doi_str_mv | 10.1017/S0950268823001528 |
| format | Article |
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Day care centre (DCC) attendance is a risk factor for MDRO carriage in children and their environment. This study aimed to map the epidemiology of carriage and potential transmission of these organisms within 18 Flemish DDCs (Belgium). An MDRO prevalence survey was organised between November 2018 and February 2019 among children attending the centres. Selective chromogenic culture media were used for the detection of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenemase-producing Enterobacterales (CPE), and vancomycin-resistant Enterococci (VRE) in faecal swabs obtained from diapers or jars (n = 448). All isolated MDROs were subjected to resistance gene sequencing. A total of 71 of 448 samples (15.8%) yielded isolates of ESBL-E with a predominance of Escherichia coli (92.2% of ESBL-E) and ESBL resistance gene blaCTX-M-15 (50.7% of ESBL coding genes in E. coli). ESBL-E prevalence varied between DCCs, ranging from 0 to 50%. Transmission, based on the clonal relatedness of ESBL-E strains, was observed. CPE was identified in only one child carrying an E. coli with an OXA-244 gene. VRE was absent from all samples. The observed prevalence of ESBL-E in Flemish DCCs is high compared with previous studies, and our findings re-emphasise the need for rigorous hygiene measures within such centres to control the further spread of MDROs in the community.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268823001528</identifier><identifier>PMID: 37711023</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Algorithms ; Antibiotic resistance ; Carbapenemase ; Children ; Culture media ; Day care centers ; E coli ; Enterobacterales ; Epidemiology ; Escherichia coli ; Gene sequencing ; Genes ; Genomes ; Health risks ; Hygiene ; Multidrug resistance ; Multidrug resistant organisms ; Mutation ; Original Paper ; Public health ; Risk factors ; Selective media ; Vancomycin ; β Lactamase</subject><ispartof>Epidemiology and infection, 2023-09, Vol.151, Article e156</ispartof><rights>The Author(s), 2023. Published by Cambridge University Press</rights><rights>The Author(s), 2023. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023 2023 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-b20b63dcd38c2c36a8929eda3021db3bb3c6442bf291af0e677de76a7b9e6acb3</cites><orcidid>0000-0002-0685-7553 ; 0000-0001-9859-8589 ; 0000-0001-7105-3001 ; 0000-0001-9500-3674 ; 0000-0003-2137-2068 ; 0000-0002-6576-6408</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548538/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0950268823001528/type/journal_article$$EHTML$$P50$$Gcambridge$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,23318,27924,27925,53791,53793,55804</link.rule.ids></links><search><creatorcontrib>van Kleef – van Koeveringe, Stefanie</creatorcontrib><creatorcontrib>Matheeussen, Veerle</creatorcontrib><creatorcontrib>Jansens, Hilde</creatorcontrib><creatorcontrib>Perales Selva, Natascha</creatorcontrib><creatorcontrib>De Coninck, Dieter</creatorcontrib><creatorcontrib>De Bruyne, Katrien</creatorcontrib><creatorcontrib>Mensaert, Klaas</creatorcontrib><creatorcontrib>Kluytmans - van den Bergh, Marjolein</creatorcontrib><creatorcontrib>Kluytmans, Jan</creatorcontrib><creatorcontrib>Goossens, Herman</creatorcontrib><creatorcontrib>Dhaeze, Wouter</creatorcontrib><creatorcontrib>on behalf of the i-4-1-Health Study Group</creatorcontrib><title>Epidemiology and molecular typing of multidrug-resistant bacteria in day care centres in Flanders, Belgium</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>The global prevalence and spread of multidrug-resistant organisms (MDROs) represent an emerging public health threat. Day care centre (DCC) attendance is a risk factor for MDRO carriage in children and their environment. This study aimed to map the epidemiology of carriage and potential transmission of these organisms within 18 Flemish DDCs (Belgium). An MDRO prevalence survey was organised between November 2018 and February 2019 among children attending the centres. Selective chromogenic culture media were used for the detection of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenemase-producing Enterobacterales (CPE), and vancomycin-resistant Enterococci (VRE) in faecal swabs obtained from diapers or jars (n = 448). All isolated MDROs were subjected to resistance gene sequencing. A total of 71 of 448 samples (15.8%) yielded isolates of ESBL-E with a predominance of Escherichia coli (92.2% of ESBL-E) and ESBL resistance gene blaCTX-M-15 (50.7% of ESBL coding genes in E. coli). ESBL-E prevalence varied between DCCs, ranging from 0 to 50%. Transmission, based on the clonal relatedness of ESBL-E strains, was observed. CPE was identified in only one child carrying an E. coli with an OXA-244 gene. VRE was absent from all samples. The observed prevalence of ESBL-E in Flemish DCCs is high compared with previous studies, and our findings re-emphasise the need for rigorous hygiene measures within such centres to control the further spread of MDROs in the community.</description><subject>Algorithms</subject><subject>Antibiotic resistance</subject><subject>Carbapenemase</subject><subject>Children</subject><subject>Culture media</subject><subject>Day care centers</subject><subject>E coli</subject><subject>Enterobacterales</subject><subject>Epidemiology</subject><subject>Escherichia coli</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Genomes</subject><subject>Health risks</subject><subject>Hygiene</subject><subject>Multidrug resistance</subject><subject>Multidrug resistant organisms</subject><subject>Mutation</subject><subject>Original Paper</subject><subject>Public health</subject><subject>Risk factors</subject><subject>Selective media</subject><subject>Vancomycin</subject><subject>β Lactamase</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>IKXGN</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU-LFDEQxYMo7uzqB_AW8GqvlaT_JCfRZVeFBQ_qOVSS6jZDd2dMuoX59va4gyLiqaDee78qqhh7IeBagOhefwbTgGy1lgpANFI_YjtRt6aqazCP2e4kVyf9gl2WsgcAI3X3lF2orhMCpNqx_e0hBppiGtNw5DgHPqWR_Dpi5svxEOeBp55P67jEkNehylRiWXBeuEO_UI7I48wDHrnHTNzTvGyWU-9u3GiUyyv-jsYhrtMz9qTHsdDzc71iX-9uv9x8qO4_vf948_a-8qrVS-UkuFYFH5T2cmuhNtJQQAVSBKecU76ta-l6aQT2QG3XBepa7JyhFr1TV-zNA_ewuonCr5VwtIccJ8xHmzDav5U5frND-mEFNLVulN4IL8-EnL6vVBa7T2uet6Xtdj8w0AjVbC7x4PI5lZKp_z1CgD39x_7zny2jzhmcXI5hoD_o_6d-Aoa3kzE</recordid><startdate>20230915</startdate><enddate>20230915</enddate><creator>van Kleef – van Koeveringe, Stefanie</creator><creator>Matheeussen, Veerle</creator><creator>Jansens, Hilde</creator><creator>Perales Selva, Natascha</creator><creator>De Coninck, Dieter</creator><creator>De Bruyne, Katrien</creator><creator>Mensaert, Klaas</creator><creator>Kluytmans - 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van den Bergh, Marjolein</creatorcontrib><creatorcontrib>Kluytmans, Jan</creatorcontrib><creatorcontrib>Goossens, Herman</creatorcontrib><creatorcontrib>Dhaeze, Wouter</creatorcontrib><creatorcontrib>on behalf of the i-4-1-Health Study Group</creatorcontrib><collection>Cambridge Journals Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Kleef – van Koeveringe, Stefanie</au><au>Matheeussen, Veerle</au><au>Jansens, Hilde</au><au>Perales Selva, Natascha</au><au>De Coninck, Dieter</au><au>De Bruyne, Katrien</au><au>Mensaert, Klaas</au><au>Kluytmans - van den Bergh, Marjolein</au><au>Kluytmans, Jan</au><au>Goossens, Herman</au><au>Dhaeze, Wouter</au><aucorp>on behalf of the i-4-1-Health Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology and molecular typing of multidrug-resistant bacteria in day care centres in Flanders, Belgium</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2023-09-15</date><risdate>2023</risdate><volume>151</volume><artnum>e156</artnum><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>The global prevalence and spread of multidrug-resistant organisms (MDROs) represent an emerging public health threat. Day care centre (DCC) attendance is a risk factor for MDRO carriage in children and their environment. This study aimed to map the epidemiology of carriage and potential transmission of these organisms within 18 Flemish DDCs (Belgium). An MDRO prevalence survey was organised between November 2018 and February 2019 among children attending the centres. Selective chromogenic culture media were used for the detection of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E), carbapenemase-producing Enterobacterales (CPE), and vancomycin-resistant Enterococci (VRE) in faecal swabs obtained from diapers or jars (n = 448). All isolated MDROs were subjected to resistance gene sequencing. A total of 71 of 448 samples (15.8%) yielded isolates of ESBL-E with a predominance of Escherichia coli (92.2% of ESBL-E) and ESBL resistance gene blaCTX-M-15 (50.7% of ESBL coding genes in E. coli). ESBL-E prevalence varied between DCCs, ranging from 0 to 50%. Transmission, based on the clonal relatedness of ESBL-E strains, was observed. CPE was identified in only one child carrying an E. coli with an OXA-244 gene. VRE was absent from all samples. The observed prevalence of ESBL-E in Flemish DCCs is high compared with previous studies, and our findings re-emphasise the need for rigorous hygiene measures within such centres to control the further spread of MDROs in the community.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>37711023</pmid><doi>10.1017/S0950268823001528</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0685-7553</orcidid><orcidid>https://orcid.org/0000-0001-9859-8589</orcidid><orcidid>https://orcid.org/0000-0001-7105-3001</orcidid><orcidid>https://orcid.org/0000-0001-9500-3674</orcidid><orcidid>https://orcid.org/0000-0003-2137-2068</orcidid><orcidid>https://orcid.org/0000-0002-6576-6408</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Epidemiology and infection, 2023-09, Vol.151, Article e156 |
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| source | Cambridge Journals Open Access; DOAJ Directory of Open Access Journals; PubMed Central |
| subjects | Algorithms Antibiotic resistance Carbapenemase Children Culture media Day care centers E coli Enterobacterales Epidemiology Escherichia coli Gene sequencing Genes Genomes Health risks Hygiene Multidrug resistance Multidrug resistant organisms Mutation Original Paper Public health Risk factors Selective media Vancomycin β Lactamase |
| title | Epidemiology and molecular typing of multidrug-resistant bacteria in day care centres in Flanders, Belgium |
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