Urinary excretion kinetics of [177Lu]Lu-PSMA-617
Introduction For the implementation of suitable radiation safety measures in [ 177 Lu]Lu-PSMA-617 therapy, additional insight into excretion kinetics is important. This study evaluates this kinetics in prostate cancer patients via direct urine measurements. Methods Both the short-term (up to 24 h, n...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2023-10, Vol.50 (12), p.3572-3575 |
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| creator | de Bakker, Maarten Dominicus, Noa Meeuwis, Antoi Janssen, Marcel Konijnenberg, Mark W. Nagarajah, James Peters, Steffie M. B. |
| description | Introduction
For the implementation of suitable radiation safety measures in [
177
Lu]Lu-PSMA-617 therapy, additional insight into excretion kinetics is important. This study evaluates this kinetics in prostate cancer patients via direct urine measurements.
Methods
Both the short-term (up to 24 h,
n
= 28 cycles) and long-term kinetics (up to 7 weeks,
n
= 35 samples) were evaluated by collection of urine samples. Samples were measured on a scintillation counter to determine excretion kinetics.
Results
The mean excretion half-time during the first 20 h was 4.9 h. Kinetics was significantly different for patients with kidney function below or above eGFR 65 ml/min. Calculated skin equivalent dose in case of urinary contamination was between 50 and 145 mSv when it was caused between 0 and 8 h p.i.. Measurable amounts of
177
Lu were found in urine samples up to 18 days p.i..
Conclusion
Excretion kinetics of [
177
Lu]Lu-PSMA-617 is especially relevant during the first 24 h, when accurate radiation safety measures are important to prevent skin contamination. Measures for accurate waste management are relevant up to 18 days. |
| doi_str_mv | 10.1007/s00259-023-06328-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10547615</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2871972367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-8f85c2d12948971112518759111ead221db2eb897f0e6e5ab1236bf19232b8f13</originalsourceid><addsrcrecordid>eNp9kUtLAzEUhYMotlb_gAspuHETzb0zmSQrKcUXjChoVyJhHpk6tZ2pSUf035s6tT4WrnLgfvfkXA4h-8COgTFx4hhDrijDgLIoQEnlBulCBIoKJtXmWgvWITvOTRgDiVJtk04gQoQQRZewkS2rxL73zVtmzaKsq_5zWXmRuX5d9B9AiLh5jBt6e3c9oBGIXbJVJFNn9lZvj4zOz-6HlzS-ubgaDmKahYIvqCwkzzAHVKFUAgCQgxRceWWSHBHyFE3qRwUzkeFJChhEaQEKA0xlAUGPnLa-8yadmTwz1cImUz235czH1XVS6t-TqnzS4_pVA-OhiIB7h6OVg61fGuMWela6zEynSWXqxmmUAcdIKSE9evgHndSNrfx9nhKghA8nPIUtldnaOWuKdRpgetmIbhvRvhH92YheWh_8vGO98lWBB4IWcH5UjY39_vsf2w8Z15M4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2871972367</pqid></control><display><type>article</type><title>Urinary excretion kinetics of [177Lu]Lu-PSMA-617</title><source>Springer Nature - Complete Springer Journals</source><creator>de Bakker, Maarten ; Dominicus, Noa ; Meeuwis, Antoi ; Janssen, Marcel ; Konijnenberg, Mark W. ; Nagarajah, James ; Peters, Steffie M. B.</creator><creatorcontrib>de Bakker, Maarten ; Dominicus, Noa ; Meeuwis, Antoi ; Janssen, Marcel ; Konijnenberg, Mark W. ; Nagarajah, James ; Peters, Steffie M. B.</creatorcontrib><description>Introduction
For the implementation of suitable radiation safety measures in [
177
Lu]Lu-PSMA-617 therapy, additional insight into excretion kinetics is important. This study evaluates this kinetics in prostate cancer patients via direct urine measurements.
Methods
Both the short-term (up to 24 h,
n
= 28 cycles) and long-term kinetics (up to 7 weeks,
n
= 35 samples) were evaluated by collection of urine samples. Samples were measured on a scintillation counter to determine excretion kinetics.
Results
The mean excretion half-time during the first 20 h was 4.9 h. Kinetics was significantly different for patients with kidney function below or above eGFR 65 ml/min. Calculated skin equivalent dose in case of urinary contamination was between 50 and 145 mSv when it was caused between 0 and 8 h p.i.. Measurable amounts of
177
Lu were found in urine samples up to 18 days p.i..
Conclusion
Excretion kinetics of [
177
Lu]Lu-PSMA-617 is especially relevant during the first 24 h, when accurate radiation safety measures are important to prevent skin contamination. Measures for accurate waste management are relevant up to 18 days.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-023-06328-8</identifier><identifier>PMID: 37421427</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cardiology ; Contamination ; Excretion ; Imaging ; Kinetics ; Lutetium isotopes ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Oncology ; Orthopedics ; Prostate cancer ; Radiation ; Radiation measurement ; Radiology ; Safety measures ; Scintillation counters ; Short Communication ; Urine ; Waste management</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2023-10, Vol.50 (12), p.3572-3575</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-8f85c2d12948971112518759111ead221db2eb897f0e6e5ab1236bf19232b8f13</citedby><cites>FETCH-LOGICAL-c475t-8f85c2d12948971112518759111ead221db2eb897f0e6e5ab1236bf19232b8f13</cites><orcidid>0000-0002-0752-7134</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-023-06328-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-023-06328-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37421427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Bakker, Maarten</creatorcontrib><creatorcontrib>Dominicus, Noa</creatorcontrib><creatorcontrib>Meeuwis, Antoi</creatorcontrib><creatorcontrib>Janssen, Marcel</creatorcontrib><creatorcontrib>Konijnenberg, Mark W.</creatorcontrib><creatorcontrib>Nagarajah, James</creatorcontrib><creatorcontrib>Peters, Steffie M. B.</creatorcontrib><title>Urinary excretion kinetics of [177Lu]Lu-PSMA-617</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Introduction
For the implementation of suitable radiation safety measures in [
177
Lu]Lu-PSMA-617 therapy, additional insight into excretion kinetics is important. This study evaluates this kinetics in prostate cancer patients via direct urine measurements.
Methods
Both the short-term (up to 24 h,
n
= 28 cycles) and long-term kinetics (up to 7 weeks,
n
= 35 samples) were evaluated by collection of urine samples. Samples were measured on a scintillation counter to determine excretion kinetics.
Results
The mean excretion half-time during the first 20 h was 4.9 h. Kinetics was significantly different for patients with kidney function below or above eGFR 65 ml/min. Calculated skin equivalent dose in case of urinary contamination was between 50 and 145 mSv when it was caused between 0 and 8 h p.i.. Measurable amounts of
177
Lu were found in urine samples up to 18 days p.i..
Conclusion
Excretion kinetics of [
177
Lu]Lu-PSMA-617 is especially relevant during the first 24 h, when accurate radiation safety measures are important to prevent skin contamination. Measures for accurate waste management are relevant up to 18 days.</description><subject>Cardiology</subject><subject>Contamination</subject><subject>Excretion</subject><subject>Imaging</subject><subject>Kinetics</subject><subject>Lutetium isotopes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Orthopedics</subject><subject>Prostate cancer</subject><subject>Radiation</subject><subject>Radiation measurement</subject><subject>Radiology</subject><subject>Safety measures</subject><subject>Scintillation counters</subject><subject>Short Communication</subject><subject>Urine</subject><subject>Waste management</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtLAzEUhYMotlb_gAspuHETzb0zmSQrKcUXjChoVyJhHpk6tZ2pSUf035s6tT4WrnLgfvfkXA4h-8COgTFx4hhDrijDgLIoQEnlBulCBIoKJtXmWgvWITvOTRgDiVJtk04gQoQQRZewkS2rxL73zVtmzaKsq_5zWXmRuX5d9B9AiLh5jBt6e3c9oBGIXbJVJFNn9lZvj4zOz-6HlzS-ubgaDmKahYIvqCwkzzAHVKFUAgCQgxRceWWSHBHyFE3qRwUzkeFJChhEaQEKA0xlAUGPnLa-8yadmTwz1cImUz235czH1XVS6t-TqnzS4_pVA-OhiIB7h6OVg61fGuMWela6zEynSWXqxmmUAcdIKSE9evgHndSNrfx9nhKghA8nPIUtldnaOWuKdRpgetmIbhvRvhH92YheWh_8vGO98lWBB4IWcH5UjY39_vsf2w8Z15M4</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>de Bakker, Maarten</creator><creator>Dominicus, Noa</creator><creator>Meeuwis, Antoi</creator><creator>Janssen, Marcel</creator><creator>Konijnenberg, Mark W.</creator><creator>Nagarajah, James</creator><creator>Peters, Steffie M. B.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0752-7134</orcidid></search><sort><creationdate>20231001</creationdate><title>Urinary excretion kinetics of [177Lu]Lu-PSMA-617</title><author>de Bakker, Maarten ; Dominicus, Noa ; Meeuwis, Antoi ; Janssen, Marcel ; Konijnenberg, Mark W. ; Nagarajah, James ; Peters, Steffie M. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-8f85c2d12948971112518759111ead221db2eb897f0e6e5ab1236bf19232b8f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiology</topic><topic>Contamination</topic><topic>Excretion</topic><topic>Imaging</topic><topic>Kinetics</topic><topic>Lutetium isotopes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Orthopedics</topic><topic>Prostate cancer</topic><topic>Radiation</topic><topic>Radiation measurement</topic><topic>Radiology</topic><topic>Safety measures</topic><topic>Scintillation counters</topic><topic>Short Communication</topic><topic>Urine</topic><topic>Waste management</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Bakker, Maarten</creatorcontrib><creatorcontrib>Dominicus, Noa</creatorcontrib><creatorcontrib>Meeuwis, Antoi</creatorcontrib><creatorcontrib>Janssen, Marcel</creatorcontrib><creatorcontrib>Konijnenberg, Mark W.</creatorcontrib><creatorcontrib>Nagarajah, James</creatorcontrib><creatorcontrib>Peters, Steffie M. B.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Bakker, Maarten</au><au>Dominicus, Noa</au><au>Meeuwis, Antoi</au><au>Janssen, Marcel</au><au>Konijnenberg, Mark W.</au><au>Nagarajah, James</au><au>Peters, Steffie M. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary excretion kinetics of [177Lu]Lu-PSMA-617</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>50</volume><issue>12</issue><spage>3572</spage><epage>3575</epage><pages>3572-3575</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Introduction
For the implementation of suitable radiation safety measures in [
177
Lu]Lu-PSMA-617 therapy, additional insight into excretion kinetics is important. This study evaluates this kinetics in prostate cancer patients via direct urine measurements.
Methods
Both the short-term (up to 24 h,
n
= 28 cycles) and long-term kinetics (up to 7 weeks,
n
= 35 samples) were evaluated by collection of urine samples. Samples were measured on a scintillation counter to determine excretion kinetics.
Results
The mean excretion half-time during the first 20 h was 4.9 h. Kinetics was significantly different for patients with kidney function below or above eGFR 65 ml/min. Calculated skin equivalent dose in case of urinary contamination was between 50 and 145 mSv when it was caused between 0 and 8 h p.i.. Measurable amounts of
177
Lu were found in urine samples up to 18 days p.i..
Conclusion
Excretion kinetics of [
177
Lu]Lu-PSMA-617 is especially relevant during the first 24 h, when accurate radiation safety measures are important to prevent skin contamination. Measures for accurate waste management are relevant up to 18 days.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37421427</pmid><doi>10.1007/s00259-023-06328-8</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-0752-7134</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10547615 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Cardiology Contamination Excretion Imaging Kinetics Lutetium isotopes Medicine Medicine & Public Health Nuclear Medicine Oncology Orthopedics Prostate cancer Radiation Radiation measurement Radiology Safety measures Scintillation counters Short Communication Urine Waste management |
| title | Urinary excretion kinetics of [177Lu]Lu-PSMA-617 |
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