Mitogen-induced defective mitosis transforms neural progenitor cells

Abstract Background Chromosome instability (CIN) with recurrent copy number alterations is a feature of many solid tumors, including glioblastoma (GBM), yet the genes that regulate cell division are rarely mutated in cancers. Here, we show that the brain-abundant mitogen, platelet-derived growth fac...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2023-10, Vol.25 (10), p.1763-1774
Hauptverfasser:	Omairi, Hiba K, Grisdale, Cameron J, Meode, Mathieu, Bohm, Alexandra K, Black, Sophie, Adam, Nancy J, Chapman, Cassidy P, Maroilley, Tatiana, Kelly, John J, Tarailo-Graovac, Maja, Jones, Steven J M, Blough, Michael D, Cairncross, John Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic and Translational Investigations Glioblastoma - pathology Humans Mice Mitogens - metabolism Mitosis Neural Stem Cells - pathology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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