Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins

A complex interplay between mRNA translation and cellular respiration has been recently unveiled, but its regulation in humans is poorly characterized in either health or disease. Cancer cells radically reshape both biosynthetic and bioenergetic pathways to sustain their aberrant growth rates. In th...

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Veröffentlicht in:	Genome research 2023-08, Vol.33 (8), p.1242-1257
Hauptverfasser:	Avolio, Rosario, Agliarulo, Ilenia, Criscuolo, Daniela, Sarnataro, Daniela, Auriemma, Margherita, De Lella, Sabrina, Pennacchio, Sara, Calice, Giovanni, Ng, Martin Y, Giorgi, Carlotta, Pinton, Paolo, Cooperman, Barry S, Landriscina, Matteo, Esposito, Franca, Matassa, Danilo Swann
Format:	Artikel
Sprache:	eng
Schlagworte:	Energy metabolism HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Molecular Chaperones - genetics Molecular Chaperones - metabolism Molecular modelling mRNA Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Peptide Chain Elongation, Translational - genetics Peptide Chain Elongation, Translational - physiology Protein biosynthesis Protein Biosynthesis - genetics Protein Biosynthesis - physiology Protein turnover Respiration Ribosomes Ribosomes - genetics Ribosomes - metabolism Translation elongation Tumor suppressor genes
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