Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling

Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) with various etiologies, which seriously affects the structure and function of the kidney. Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily and plays a critical role in regulating the genes relat...

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Veröffentlicht in:	Acta pharmacologica Sinica 2023-10, Vol.44 (10), p.2075-2090
Hauptverfasser:	Ming, Wen-hua, Luan, Zhi-lin, Yao, Yao, Liu, Hang-chi, Hu, Shu-yuan, Du, Chun-xiu, Zhang, Cong, Zhao, Yi-hang, Huang, Ying-zhi, Sun, Xiao-wan, Qiao, Rong-fang, Xu, Hu, Guan, You-fei, Zhang, Xiao-yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Biomedical and Life Sciences Biomedicine Epithelial cells Fibronectin Fibrosis Genes Humans Immunology Internal Medicine Kidney diseases Mammals - metabolism Medical Microbiology Mice p53 Protein Pharmacology/Toxicology Pregnane X Receptor - metabolism Pregnane X receptors Pregnenolone Receptor mechanisms Receptors, Steroid - genetics Receptors, Steroid - metabolism Renal function Renal Insufficiency, Chronic - chemically induced Renal Insufficiency, Chronic - drug therapy Rifampin Rifampin - pharmacology Signal Transduction Structure-function relationships Transcription activation Transforming growth factor-b1 Tumor Suppressor Protein p53 - metabolism Ureter Vaccine Wnt Signaling Pathway β-Catenin
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