An Evolutionarily Conserved Strategy for Ribosome Binding and Host Translation Inhibition by β-coronavirus Non-structural Protein 1

[Display omitted] •α- and β-CoV Nsp1s inhibit gene expression.•The CTD of all β-CoV Nsp1s confers high-affinity ribosome binding despite low sequence conservation.•Conservation in surface charge, rather than amino acid sequence, mediates ribosome binding of beta-CoV Nsp1s.•The Nsp1 CTD is an ineffic...

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