Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS)
Purpose Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of autoantibodies in human sera of participants with different stages of AMD in a large population-based, observational cohort study in Germany...
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| creator | Korb, Christina A. Lackner, Karl J. Wolters, Dominik Schuster, Alexander K. Nickels, Stefan Beutgen, Vanessa M. Münzel, Thomas Wild, Philipp S. Beutel, Manfred E. Schmidtmann, Irene Pfeiffer, Norbert Grus, Franz H. |
| description | Purpose
Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of autoantibodies in human sera of participants with different stages of AMD in a large population-based, observational cohort study in Germany.
Methods
The Gutenberg Health Study (GHS) is a population-based, observational cohort study in Germany, including 15,010 participants aged between 35 and 74. Amongst others, non-mydriatic fundus photography (Visucam PRO NM™, Carl Zeiss Meditec AG, Jena, Germany) was performed. Fundus images of the first 5000 participants were graded based on the Rotterdam Eye Study classification. Sera of participants with AMD (
n
=541) and sera of age-matched participants without AMD (
n
=490) were analyzed by antigen-microarrays. Besides descriptive statistics, autoantibody-levels were compared by Mann-Whitney-U test and the associations of level of autoantibodies with AMD were calculated by logistic regression analysis. Likewise, possible associations of the autoantibodies and both clinical and laboratory parameters on AMD subjects were analyzed.
Results
Autoantibodies against transferrin (
p |
| doi_str_mv | 10.1007/s00417-023-06085-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10543519</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2811941081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-23d487253c339c0024fb9161d1e4a34de9ee19064e7e716a0ee375e6a3741a473</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EokvhD3BAlrhsD4HxV5xwQasCu0hFSBSk3iwnmWRTZeOt7RT17_BL8TalfBw4-TDPvDPv-CXkOYNXDEC_DgCS6Qy4yCCHQmX8AVkwKVSmgV88JAvQnGWF4BdH5EkIl5B4odhjciQ0y0EBX5AfqxBc3dvYu5G6ltopOjvGvnLNDR3wGodAv_dxS5u-bdHjGGmItsNwC3eYeRxsxIbubD0N1tMGOxzRz4LL1ad3J2_oFwzTEANtvdvRuEW6d_sEH5CssiF1r6eIY4W-oxu0Qxp3Hqe0wHK9OT95Sh61dgj47O49Jt8-vP96usnOPq8_nq7OslpqFTMuGllorkQtRFkDcNlWJctZw1BaIRssEVkJuUSNyb4FRKEV5lZoyazU4pi8nXX3U7XDpk5evR3M3vc762-Ms735uzL2W9O5a8NAHe5aJoXlnYJ3VxOGaHZ9qHEY7IhuCoYXjJWSQcES-vIf9NJNfkz-EqVBaVGoIlF8pmrvQvDY3m_DwBwyYOYMmJQBc5sBw1PTiz993Lf8-vQEiBkIqTR26H_P_o_sT4WVvoU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2870573858</pqid></control><display><type>article</type><title>Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS)</title><source>Springer Nature - Complete Springer Journals</source><creator>Korb, Christina A. ; Lackner, Karl J. ; Wolters, Dominik ; Schuster, Alexander K. ; Nickels, Stefan ; Beutgen, Vanessa M. ; Münzel, Thomas ; Wild, Philipp S. ; Beutel, Manfred E. ; Schmidtmann, Irene ; Pfeiffer, Norbert ; Grus, Franz H.</creator><creatorcontrib>Korb, Christina A. ; Lackner, Karl J. ; Wolters, Dominik ; Schuster, Alexander K. ; Nickels, Stefan ; Beutgen, Vanessa M. ; Münzel, Thomas ; Wild, Philipp S. ; Beutel, Manfred E. ; Schmidtmann, Irene ; Pfeiffer, Norbert ; Grus, Franz H.</creatorcontrib><description>Purpose
Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of autoantibodies in human sera of participants with different stages of AMD in a large population-based, observational cohort study in Germany.
Methods
The Gutenberg Health Study (GHS) is a population-based, observational cohort study in Germany, including 15,010 participants aged between 35 and 74. Amongst others, non-mydriatic fundus photography (Visucam PRO NM™, Carl Zeiss Meditec AG, Jena, Germany) was performed. Fundus images of the first 5000 participants were graded based on the Rotterdam Eye Study classification. Sera of participants with AMD (
n
=541) and sera of age-matched participants without AMD (
n
=490) were analyzed by antigen-microarrays. Besides descriptive statistics, autoantibody-levels were compared by Mann-Whitney-U test and the associations of level of autoantibodies with AMD were calculated by logistic regression analysis. Likewise, possible associations of the autoantibodies and both clinical and laboratory parameters on AMD subjects were analyzed.
Results
Autoantibodies against transferrin (
p
<0.001) were significantly downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only compared to Controls. Mitogen-activated protein kinase 3 (
p
=0.041), glutathione peroxidase 4 (
p
=0.048), clusterin (
p
=0.045), lysozyme (
p
=0.19), protein kinase C substrate 80K-H (
p
=0.02), heat shock 70 kDa protein 1A (
p
=0.04) and insulin (
p
=0.018) show a trend between Control and participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only.
Conclusions
This study contributes to a growing knowledge of autoantibodies in association with different AMD stages compared to controls in the context of a large population-based study in Germany. Especially autoantibodies against inflammatory proteins were downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-023-06085-2</identifier><identifier>PMID: 37160502</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autoantibodies ; Clusterin ; Cohort analysis ; Down-regulation ; Glutathione peroxidase ; Heat shock proteins ; Inflammation ; Kinases ; Lysozyme ; Macular degeneration ; MAP kinase ; Medicine ; Medicine & Public Health ; Ophthalmology ; Photography ; Population studies ; Population-based studies ; Protein kinase C ; Proteins ; Retinal Disorders ; Statistical analysis</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2023-10, Vol.261 (10), p.2763-2773</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-23d487253c339c0024fb9161d1e4a34de9ee19064e7e716a0ee375e6a3741a473</citedby><cites>FETCH-LOGICAL-c475t-23d487253c339c0024fb9161d1e4a34de9ee19064e7e716a0ee375e6a3741a473</cites><orcidid>0000-0001-7572-4749</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-023-06085-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-023-06085-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,778,782,883,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37160502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Korb, Christina A.</creatorcontrib><creatorcontrib>Lackner, Karl J.</creatorcontrib><creatorcontrib>Wolters, Dominik</creatorcontrib><creatorcontrib>Schuster, Alexander K.</creatorcontrib><creatorcontrib>Nickels, Stefan</creatorcontrib><creatorcontrib>Beutgen, Vanessa M.</creatorcontrib><creatorcontrib>Münzel, Thomas</creatorcontrib><creatorcontrib>Wild, Philipp S.</creatorcontrib><creatorcontrib>Beutel, Manfred E.</creatorcontrib><creatorcontrib>Schmidtmann, Irene</creatorcontrib><creatorcontrib>Pfeiffer, Norbert</creatorcontrib><creatorcontrib>Grus, Franz H.</creatorcontrib><title>Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS)</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of autoantibodies in human sera of participants with different stages of AMD in a large population-based, observational cohort study in Germany.
Methods
The Gutenberg Health Study (GHS) is a population-based, observational cohort study in Germany, including 15,010 participants aged between 35 and 74. Amongst others, non-mydriatic fundus photography (Visucam PRO NM™, Carl Zeiss Meditec AG, Jena, Germany) was performed. Fundus images of the first 5000 participants were graded based on the Rotterdam Eye Study classification. Sera of participants with AMD (
n
=541) and sera of age-matched participants without AMD (
n
=490) were analyzed by antigen-microarrays. Besides descriptive statistics, autoantibody-levels were compared by Mann-Whitney-U test and the associations of level of autoantibodies with AMD were calculated by logistic regression analysis. Likewise, possible associations of the autoantibodies and both clinical and laboratory parameters on AMD subjects were analyzed.
Results
Autoantibodies against transferrin (
p
<0.001) were significantly downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only compared to Controls. Mitogen-activated protein kinase 3 (
p
=0.041), glutathione peroxidase 4 (
p
=0.048), clusterin (
p
=0.045), lysozyme (
p
=0.19), protein kinase C substrate 80K-H (
p
=0.02), heat shock 70 kDa protein 1A (
p
=0.04) and insulin (
p
=0.018) show a trend between Control and participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only.
Conclusions
This study contributes to a growing knowledge of autoantibodies in association with different AMD stages compared to controls in the context of a large population-based study in Germany. Especially autoantibodies against inflammatory proteins were downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only.</description><subject>Autoantibodies</subject><subject>Clusterin</subject><subject>Cohort analysis</subject><subject>Down-regulation</subject><subject>Glutathione peroxidase</subject><subject>Heat shock proteins</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>Lysozyme</subject><subject>Macular degeneration</subject><subject>MAP kinase</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Photography</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Protein kinase C</subject><subject>Proteins</subject><subject>Retinal Disorders</subject><subject>Statistical analysis</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kk1v1DAQhi0EokvhD3BAlrhsD4HxV5xwQasCu0hFSBSk3iwnmWRTZeOt7RT17_BL8TalfBw4-TDPvDPv-CXkOYNXDEC_DgCS6Qy4yCCHQmX8AVkwKVSmgV88JAvQnGWF4BdH5EkIl5B4odhjciQ0y0EBX5AfqxBc3dvYu5G6ltopOjvGvnLNDR3wGodAv_dxS5u-bdHjGGmItsNwC3eYeRxsxIbubD0N1tMGOxzRz4LL1ad3J2_oFwzTEANtvdvRuEW6d_sEH5CssiF1r6eIY4W-oxu0Qxp3Hqe0wHK9OT95Sh61dgj47O49Jt8-vP96usnOPq8_nq7OslpqFTMuGllorkQtRFkDcNlWJctZw1BaIRssEVkJuUSNyb4FRKEV5lZoyazU4pi8nXX3U7XDpk5evR3M3vc762-Ms735uzL2W9O5a8NAHe5aJoXlnYJ3VxOGaHZ9qHEY7IhuCoYXjJWSQcES-vIf9NJNfkz-EqVBaVGoIlF8pmrvQvDY3m_DwBwyYOYMmJQBc5sBw1PTiz993Lf8-vQEiBkIqTR26H_P_o_sT4WVvoU</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Korb, Christina A.</creator><creator>Lackner, Karl J.</creator><creator>Wolters, Dominik</creator><creator>Schuster, Alexander K.</creator><creator>Nickels, Stefan</creator><creator>Beutgen, Vanessa M.</creator><creator>Münzel, Thomas</creator><creator>Wild, Philipp S.</creator><creator>Beutel, Manfred E.</creator><creator>Schmidtmann, Irene</creator><creator>Pfeiffer, Norbert</creator><creator>Grus, Franz H.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7572-4749</orcidid></search><sort><creationdate>20231001</creationdate><title>Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS)</title><author>Korb, Christina A. ; Lackner, Karl J. ; Wolters, Dominik ; Schuster, Alexander K. ; Nickels, Stefan ; Beutgen, Vanessa M. ; Münzel, Thomas ; Wild, Philipp S. ; Beutel, Manfred E. ; Schmidtmann, Irene ; Pfeiffer, Norbert ; Grus, Franz H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-23d487253c339c0024fb9161d1e4a34de9ee19064e7e716a0ee375e6a3741a473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Autoantibodies</topic><topic>Clusterin</topic><topic>Cohort analysis</topic><topic>Down-regulation</topic><topic>Glutathione peroxidase</topic><topic>Heat shock proteins</topic><topic>Inflammation</topic><topic>Kinases</topic><topic>Lysozyme</topic><topic>Macular degeneration</topic><topic>MAP kinase</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Photography</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Protein kinase C</topic><topic>Proteins</topic><topic>Retinal Disorders</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Korb, Christina A.</creatorcontrib><creatorcontrib>Lackner, Karl J.</creatorcontrib><creatorcontrib>Wolters, Dominik</creatorcontrib><creatorcontrib>Schuster, Alexander K.</creatorcontrib><creatorcontrib>Nickels, Stefan</creatorcontrib><creatorcontrib>Beutgen, Vanessa M.</creatorcontrib><creatorcontrib>Münzel, Thomas</creatorcontrib><creatorcontrib>Wild, Philipp S.</creatorcontrib><creatorcontrib>Beutel, Manfred E.</creatorcontrib><creatorcontrib>Schmidtmann, Irene</creatorcontrib><creatorcontrib>Pfeiffer, Norbert</creatorcontrib><creatorcontrib>Grus, Franz H.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korb, Christina A.</au><au>Lackner, Karl J.</au><au>Wolters, Dominik</au><au>Schuster, Alexander K.</au><au>Nickels, Stefan</au><au>Beutgen, Vanessa M.</au><au>Münzel, Thomas</au><au>Wild, Philipp S.</au><au>Beutel, Manfred E.</au><au>Schmidtmann, Irene</au><au>Pfeiffer, Norbert</au><au>Grus, Franz H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS)</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>261</volume><issue>10</issue><spage>2763</spage><epage>2773</epage><pages>2763-2773</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
Anti-retinal autoantibodies are assumed to be associated with age-related macular degeneration (AMD). To our knowledge, this is the first evaluation of autoantibodies in human sera of participants with different stages of AMD in a large population-based, observational cohort study in Germany.
Methods
The Gutenberg Health Study (GHS) is a population-based, observational cohort study in Germany, including 15,010 participants aged between 35 and 74. Amongst others, non-mydriatic fundus photography (Visucam PRO NM™, Carl Zeiss Meditec AG, Jena, Germany) was performed. Fundus images of the first 5000 participants were graded based on the Rotterdam Eye Study classification. Sera of participants with AMD (
n
=541) and sera of age-matched participants without AMD (
n
=490) were analyzed by antigen-microarrays. Besides descriptive statistics, autoantibody-levels were compared by Mann-Whitney-U test and the associations of level of autoantibodies with AMD were calculated by logistic regression analysis. Likewise, possible associations of the autoantibodies and both clinical and laboratory parameters on AMD subjects were analyzed.
Results
Autoantibodies against transferrin (
p
<0.001) were significantly downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only compared to Controls. Mitogen-activated protein kinase 3 (
p
=0.041), glutathione peroxidase 4 (
p
=0.048), clusterin (
p
=0.045), lysozyme (
p
=0.19), protein kinase C substrate 80K-H (
p
=0.02), heat shock 70 kDa protein 1A (
p
=0.04) and insulin (
p
=0.018) show a trend between Control and participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only.
Conclusions
This study contributes to a growing knowledge of autoantibodies in association with different AMD stages compared to controls in the context of a large population-based study in Germany. Especially autoantibodies against inflammatory proteins were downregulated in participants with early AMD and soft, distinct drusen (≥63 μm) or pigmentary abnormalities only.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37160502</pmid><doi>10.1007/s00417-023-06085-2</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7572-4749</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2023-10, Vol.261 (10), p.2763-2773 |
| issn | 0721-832X 1435-702X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10543519 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Autoantibodies Clusterin Cohort analysis Down-regulation Glutathione peroxidase Heat shock proteins Inflammation Kinases Lysozyme Macular degeneration MAP kinase Medicine Medicine & Public Health Ophthalmology Photography Population studies Population-based studies Protein kinase C Proteins Retinal Disorders Statistical analysis |
| title | Association of autoantibody levels with different stages of age-related macular degeneration (AMD): Results from the population-based Gutenberg Health Study (GHS) |
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