Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma

A major hurdle to the application of precision oncology in pancreatic cancer is the lack of molecular stratification approaches and targeted therapy for defined molecular subtypes. In this work, we sought to gain further insight and identify molecular and epigenetic signatures of the Basal-like A pa...

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Veröffentlicht in:	Molecular cancer research 2023-09, Vol.21 (9), p.881-891
Hauptverfasser:	Wang, Xin, Kutschat, Ana P, Aggrey-Fynn, Joana, Hamdan, Feda H, Graham, Rondell P, Wixom, Alexander Q, Souto, Yara, Ladigan-Badura, Swetlana, Yonkus, Jennifer A, Abdelrahman, Amro M, Alva-Ruiz, Roberto, Gaedcke, Jochen, Ströbel, Philipp, Kosinsky, Robyn Laura, Wegwitz, Florian, Hermann, Patrick, Truty, Mark J, Siveke, Jens T, Hahn, Stephan A, Hessmann, Elisabeth, Johnsen, Steven A, Najafova, Zeynab
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Pancreatic Ductal - pathology Gene Expression Regulation, Neoplastic Humans Pancreatic Neoplasms - pathology Precision Medicine RNA
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