Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell
Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon...
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| Veröffentlicht in: | Diabetologia 2023-11, Vol.66 (11), p.1971-1982 |
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| container_end_page | 1982 |
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| container_issue | 11 |
| container_start_page | 1971 |
| container_title | Diabetologia |
| container_volume | 66 |
| creator | Thompson, Peter J. Pipella, Jasmine Rutter, Guy A. Gaisano, Herbert Y. Santamaria, Pere |
| description | Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon early life exposures affecting the islets, especially beta cells. Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. Future progress in this area holds promise for advancing islet- and beta cell-directed therapies that could be implemented in the early stages of the disease and could be combined with immunotherapies.
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| doi_str_mv | 10.1007/s00125-023-05970-z |
| format | Article |
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Graphical Abstract</description><subject>Antigen presentation</subject><subject>Autoimmunity</subject><subject>Autoimmunity - physiology</subject><subject>Beta cells</subject><subject>Cellular stress response</subject><subject>Diabetes</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - metabolism</subject><subject>Genetic Predisposition to Disease</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Internal Medicine</subject><subject>Invited Review</subject><subject>Islets of Langerhans - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU9v1DAQxS0EotvCF-CALHHhEvDYTuxwQaiiUKkSF5C4Wd7seNdVYgfbqbT99Hi7pfw5cLFlv9-8mdEj5AWwN8CYepsZA942jIuGtb1ize0jsgIpeMMk14_J6qA3oLvvJ-Q052vGmGhl95ScCCW1FpyvyHSZRyzULiX6aVqCL3vqA90tkw207GekQDferrFgflcVX7wtPgZqw4bOKW4T5nx4uxQnWnZIZ0x5xqH4G6TR3X3VaksHHMdn5ImzY8bn9_cZ-Xbx8ev55-bqy6fL8w9XzSBVW5oeBbJeCQ5cWJROKqyTg13r1gHHQXVSDr3urW2hHk4JREC1dq7DrlNWnJH3R995WU-4GTCUZEczJz_ZtDfRevO3EvzObOONAdZKrqCtDq_vHVL8sWAuZvL5sIINGJdsuJagNWilKvrqH_Q6LinU_SqlGKgeWF8pfqSGFHNO6B6mAWYOcZpjnKbGae7iNLe16OWfezyU_MqvAuII5CqFLabfvf9j-xMPZq2Y</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Thompson, Peter J.</creator><creator>Pipella, Jasmine</creator><creator>Rutter, Guy A.</creator><creator>Gaisano, Herbert Y.</creator><creator>Santamaria, Pere</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5213-9168</orcidid><orcidid>https://orcid.org/0000-0002-6851-8899</orcidid><orcidid>https://orcid.org/0009-0005-9936-8386</orcidid><orcidid>https://orcid.org/0000-0001-6360-0343</orcidid><orcidid>https://orcid.org/0000-0003-3469-1586</orcidid></search><sort><creationdate>20231101</creationdate><title>Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell</title><author>Thompson, Peter J. ; Pipella, Jasmine ; Rutter, Guy A. ; Gaisano, Herbert Y. ; Santamaria, Pere</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-9e3e09732123ae4f47e0351ab85f12ec7644c989aa519aaf73ee1e7bff6e667a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigen presentation</topic><topic>Autoimmunity</topic><topic>Autoimmunity - physiology</topic><topic>Beta cells</topic><topic>Cellular stress response</topic><topic>Diabetes</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes Mellitus, Type 1 - metabolism</topic><topic>Genetic Predisposition to Disease</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Internal Medicine</topic><topic>Invited Review</topic><topic>Islets of Langerhans - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, Peter J.</creatorcontrib><creatorcontrib>Pipella, Jasmine</creatorcontrib><creatorcontrib>Rutter, Guy A.</creatorcontrib><creatorcontrib>Gaisano, Herbert Y.</creatorcontrib><creatorcontrib>Santamaria, Pere</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, Peter J.</au><au>Pipella, Jasmine</au><au>Rutter, Guy A.</au><au>Gaisano, Herbert Y.</au><au>Santamaria, Pere</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell</atitle><jtitle>Diabetologia</jtitle><stitle>Diabetologia</stitle><addtitle>Diabetologia</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>66</volume><issue>11</issue><spage>1971</spage><epage>1982</epage><pages>1971-1982</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. 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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Antigen presentation Autoimmunity Autoimmunity - physiology Beta cells Cellular stress response Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - metabolism Genetic Predisposition to Disease Human Physiology Humans Immunotherapy Insulin-Secreting Cells - metabolism Internal Medicine Invited Review Islets of Langerhans - metabolism Medicine Medicine & Public Health Metabolic Diseases |
| title | Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell |
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