Coupling High-Field Asymmetric Waveform Ion Mobility Spectrometry with Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Top-Down Proteomics

Capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) has emerged as an essential technique for top-down proteomics (TDP), providing superior separation efficiency and high detection sensitivity for proteoform analysis. Here, we aimed to further enhance the performance of CZE-MS/MS for...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-06, Vol.95 (25), p.9497-9504
Hauptverfasser:	Xu, Tian, Wang, Qianjie, Wang, Qianyi, Sun, Liangliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetry Capillary electrophoresis Capillary zone Chemistry Coupling DNA-Binding Proteins Electrophoresis Electrophoresis, Capillary - methods Electrophoretic mobility Fractionation Ion Mobility Spectrometry Ionic mobility Ions Mass spectrometry Mass spectroscopy Proteomics Proteomics - methods Saccharomyces cerevisiae Scientific imaging Sensitivity analysis Tandem Mass Spectrometry - methods Waveforms Yeasts
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