Pseudomonas-dominant microbiome elicits sustained IL-1β upregulation in alveolar macrophages from lung transplant recipients

Isolation of Pseudomonas aeruginosa (PsA) is associated with increased BAL (bronchoalveolar lavage) inflammation and lung allograft injury in lung transplant recipients (LTR). However, the effect of PsA on macrophage responses in this population is incompletely understood. We examined human alveolar...

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Veröffentlicht in:	The Journal of heart and lung transplantation 2023-09, Vol.42 (9), p.1166-1174
Hauptverfasser:	Britton, Noel, Villabona-Rueda, Andres, Whiteside, Samantha A., Mathew, Joby, Kelley, Matthew, Agbor-Enoh, Sean, McDyer, John F., Christie, Jason D., Collman, Ronald G., Cox, Andrea L., Shah, Pali, D'Alessio, Franco
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Psoriatic Cytokines - metabolism Humans Inflammasomes Interleukin-6 Interleukin-8 - metabolism Lung - metabolism lung allograft injury lung transplant macrophage Macrophages, Alveolar - metabolism microbiome Pseudomonas - metabolism Pseudomonas aeruginosa Transplant Recipients Tumor Necrosis Factor-alpha Up-Regulation
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