Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients
Hemodialysis deteriorates patients’ physical, metabolic, and mental status. Clinical outcomes derived from inflammation determine a worse status but are less frequently identified. The objective of the study was to identify inflammatory determinants and the effect of SNP-related serum IL-6 and IL-10...
Gespeichert in:
| Veröffentlicht in: | Journal of personalized medicine 2023-08, Vol.13 (9), p.1311 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 9 |
| container_start_page | 1311 |
| container_title | Journal of personalized medicine |
| container_volume | 13 |
| creator | De la Cruz-Ahumada, Claudia Jackelin Topete-Reyes, Jorge Fernando Mena-Ramírez, Juan Pablo Guzmán-Flores, Juan Manuel Guzmán-González, Jesúa Ivan Ramírez-De los Santos, Saúl |
| description | Hemodialysis deteriorates patients’ physical, metabolic, and mental status. Clinical outcomes derived from inflammation determine a worse status but are less frequently identified. The objective of the study was to identify inflammatory determinants and the effect of SNP-related serum IL-6 and IL-10 levels on associated morbidity in hemodialysis. A sample of hemodialysis patients at IMSS Regional Hospital No.46 in Guadalajara (n = 85) were tested using the Malnutrition Inflammation Score (MIS) and Patient Health Questionnaire-9 (PHQ-9) to assess the associated morbidity. Serum cytokine levels were quantified by enzyme-linked immunosorbent assay (ELISA). The restriction fragment length polymorphism (RFLP) technique was used for analysis of IL-6-572C/G and IL-10-1082A/G. Using data visualization methods, we identified relevant determinants of inflammation. A simple regression model was constructed between predictors and targets with genotypes as covariates. Results showed malnutrition in 85.9% of patients and depressive symptoms in 50.6%. IL-10 was the most relevant inflammatory determinant, with regression coefficients (R2) between 0.05 and 0.11. The GG genotype of IL-10-1082 A/G evinced small effect on both clinical outcomes (δ of 0.35 and 0.37, respectively). Hemodialysis increases the associated morbidity, cytokines act as inflammatory determinants, and genetic variability contributes to the severity of clinical outcomes. Further studies need to refine the causal relationship between inflammation and CKD. |
| doi_str_mv | 10.3390/jpm13091311 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10532888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A779739650</galeid><sourcerecordid>A779739650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-da96277b5dfecd90bfb5c74dac0fa0100f2120c5bf38b6640248bf877157d0c63</originalsourceid><addsrcrecordid>eNptkctKBDEQRRtRUNSVP9DgRpDRStLdSVYy-EZFF7oO6Tw0QycZkx5h_t4Mii9MFikq597iUlW1h-CIEA7Hs7lHBDgiCK1VWxhoO2ka3K3_qDer3ZxnUA5rMe5gq7q5DnaQ3ssxpmV9ZkaTvAsyjLmWQdfTnKNycjS6voupd9qNy9qF-sr4qJ0cltnl-kGOzhTFTrVh5ZDN7ue7XT1dnD-eXk1u7y-vT6e3E9UgPE605B2mtG-1NUpz6G3fKtpoqcBKQAAWIwyq7S1hfdc1gBvWW0YpaqkG1ZHt6uTDd77ovdGqzE5yEPPkvExLEaUTv3-CexHP8U0gaAlmjBWHg0-HFF8XJo_Cu6zMMMhg4iILzCggwihuCrr_B53FRQolX6E6TjhBHL6pZzkY4YKNZbBamYoppZwS3rUr6ugfqlxtvFMxGOtK_5fg8EOgUsw5GfsVEoFYLV38WDp5B1qansY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2869393190</pqid></control><display><type>article</type><title>Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>De la Cruz-Ahumada, Claudia Jackelin ; Topete-Reyes, Jorge Fernando ; Mena-Ramírez, Juan Pablo ; Guzmán-Flores, Juan Manuel ; Guzmán-González, Jesúa Ivan ; Ramírez-De los Santos, Saúl</creator><creatorcontrib>De la Cruz-Ahumada, Claudia Jackelin ; Topete-Reyes, Jorge Fernando ; Mena-Ramírez, Juan Pablo ; Guzmán-Flores, Juan Manuel ; Guzmán-González, Jesúa Ivan ; Ramírez-De los Santos, Saúl</creatorcontrib><description>Hemodialysis deteriorates patients’ physical, metabolic, and mental status. Clinical outcomes derived from inflammation determine a worse status but are less frequently identified. The objective of the study was to identify inflammatory determinants and the effect of SNP-related serum IL-6 and IL-10 levels on associated morbidity in hemodialysis. A sample of hemodialysis patients at IMSS Regional Hospital No.46 in Guadalajara (n = 85) were tested using the Malnutrition Inflammation Score (MIS) and Patient Health Questionnaire-9 (PHQ-9) to assess the associated morbidity. Serum cytokine levels were quantified by enzyme-linked immunosorbent assay (ELISA). The restriction fragment length polymorphism (RFLP) technique was used for analysis of IL-6-572C/G and IL-10-1082A/G. Using data visualization methods, we identified relevant determinants of inflammation. A simple regression model was constructed between predictors and targets with genotypes as covariates. Results showed malnutrition in 85.9% of patients and depressive symptoms in 50.6%. IL-10 was the most relevant inflammatory determinant, with regression coefficients (R2) between 0.05 and 0.11. The GG genotype of IL-10-1082 A/G evinced small effect on both clinical outcomes (δ of 0.35 and 0.37, respectively). Hemodialysis increases the associated morbidity, cytokines act as inflammatory determinants, and genetic variability contributes to the severity of clinical outcomes. Further studies need to refine the causal relationship between inflammation and CKD.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm13091311</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Chronic kidney failure ; Clinical outcomes ; Cytokines ; Development and progression ; Enzyme-linked immunosorbent assay ; Enzymes ; Ethylenediaminetetraacetic acid ; Gene polymorphism ; Genetic testing ; Genetic variability ; Health aspects ; Hemodialysis ; Inflammation ; Interleukin 10 ; Interleukin 6 ; Kidney diseases ; Malnutrition ; Mental depression ; Mexico ; Morbidity ; Mortality ; Nutritional status ; Patients ; Polymorphism ; Precision medicine ; Questionnaires ; Restriction fragment length polymorphism ; Single-nucleotide polymorphism</subject><ispartof>Journal of personalized medicine, 2023-08, Vol.13 (9), p.1311</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c412t-da96277b5dfecd90bfb5c74dac0fa0100f2120c5bf38b6640248bf877157d0c63</cites><orcidid>0000-0001-7695-0289 ; 0000-0002-4673-112X ; 0000-0002-7433-1908</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532888/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532888/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids></links><search><creatorcontrib>De la Cruz-Ahumada, Claudia Jackelin</creatorcontrib><creatorcontrib>Topete-Reyes, Jorge Fernando</creatorcontrib><creatorcontrib>Mena-Ramírez, Juan Pablo</creatorcontrib><creatorcontrib>Guzmán-Flores, Juan Manuel</creatorcontrib><creatorcontrib>Guzmán-González, Jesúa Ivan</creatorcontrib><creatorcontrib>Ramírez-De los Santos, Saúl</creatorcontrib><title>Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients</title><title>Journal of personalized medicine</title><description>Hemodialysis deteriorates patients’ physical, metabolic, and mental status. Clinical outcomes derived from inflammation determine a worse status but are less frequently identified. The objective of the study was to identify inflammatory determinants and the effect of SNP-related serum IL-6 and IL-10 levels on associated morbidity in hemodialysis. A sample of hemodialysis patients at IMSS Regional Hospital No.46 in Guadalajara (n = 85) were tested using the Malnutrition Inflammation Score (MIS) and Patient Health Questionnaire-9 (PHQ-9) to assess the associated morbidity. Serum cytokine levels were quantified by enzyme-linked immunosorbent assay (ELISA). The restriction fragment length polymorphism (RFLP) technique was used for analysis of IL-6-572C/G and IL-10-1082A/G. Using data visualization methods, we identified relevant determinants of inflammation. A simple regression model was constructed between predictors and targets with genotypes as covariates. Results showed malnutrition in 85.9% of patients and depressive symptoms in 50.6%. IL-10 was the most relevant inflammatory determinant, with regression coefficients (R2) between 0.05 and 0.11. The GG genotype of IL-10-1082 A/G evinced small effect on both clinical outcomes (δ of 0.35 and 0.37, respectively). Hemodialysis increases the associated morbidity, cytokines act as inflammatory determinants, and genetic variability contributes to the severity of clinical outcomes. Further studies need to refine the causal relationship between inflammation and CKD.</description><subject>Chronic kidney failure</subject><subject>Clinical outcomes</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Gene polymorphism</subject><subject>Genetic testing</subject><subject>Genetic variability</subject><subject>Health aspects</subject><subject>Hemodialysis</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 6</subject><subject>Kidney diseases</subject><subject>Malnutrition</subject><subject>Mental depression</subject><subject>Mexico</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Nutritional status</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Precision medicine</subject><subject>Questionnaires</subject><subject>Restriction fragment length polymorphism</subject><subject>Single-nucleotide polymorphism</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkctKBDEQRRtRUNSVP9DgRpDRStLdSVYy-EZFF7oO6Tw0QycZkx5h_t4Mii9MFikq597iUlW1h-CIEA7Hs7lHBDgiCK1VWxhoO2ka3K3_qDer3ZxnUA5rMe5gq7q5DnaQ3ssxpmV9ZkaTvAsyjLmWQdfTnKNycjS6voupd9qNy9qF-sr4qJ0cltnl-kGOzhTFTrVh5ZDN7ue7XT1dnD-eXk1u7y-vT6e3E9UgPE605B2mtG-1NUpz6G3fKtpoqcBKQAAWIwyq7S1hfdc1gBvWW0YpaqkG1ZHt6uTDd77ovdGqzE5yEPPkvExLEaUTv3-CexHP8U0gaAlmjBWHg0-HFF8XJo_Cu6zMMMhg4iILzCggwihuCrr_B53FRQolX6E6TjhBHL6pZzkY4YKNZbBamYoppZwS3rUr6ugfqlxtvFMxGOtK_5fg8EOgUsw5GfsVEoFYLV38WDp5B1qansY</recordid><startdate>20230827</startdate><enddate>20230827</enddate><creator>De la Cruz-Ahumada, Claudia Jackelin</creator><creator>Topete-Reyes, Jorge Fernando</creator><creator>Mena-Ramírez, Juan Pablo</creator><creator>Guzmán-Flores, Juan Manuel</creator><creator>Guzmán-González, Jesúa Ivan</creator><creator>Ramírez-De los Santos, Saúl</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7695-0289</orcidid><orcidid>https://orcid.org/0000-0002-4673-112X</orcidid><orcidid>https://orcid.org/0000-0002-7433-1908</orcidid></search><sort><creationdate>20230827</creationdate><title>Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients</title><author>De la Cruz-Ahumada, Claudia Jackelin ; Topete-Reyes, Jorge Fernando ; Mena-Ramírez, Juan Pablo ; Guzmán-Flores, Juan Manuel ; Guzmán-González, Jesúa Ivan ; Ramírez-De los Santos, Saúl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-da96277b5dfecd90bfb5c74dac0fa0100f2120c5bf38b6640248bf877157d0c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chronic kidney failure</topic><topic>Clinical outcomes</topic><topic>Cytokines</topic><topic>Development and progression</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Gene polymorphism</topic><topic>Genetic testing</topic><topic>Genetic variability</topic><topic>Health aspects</topic><topic>Hemodialysis</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 6</topic><topic>Kidney diseases</topic><topic>Malnutrition</topic><topic>Mental depression</topic><topic>Mexico</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Nutritional status</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Precision medicine</topic><topic>Questionnaires</topic><topic>Restriction fragment length polymorphism</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De la Cruz-Ahumada, Claudia Jackelin</creatorcontrib><creatorcontrib>Topete-Reyes, Jorge Fernando</creatorcontrib><creatorcontrib>Mena-Ramírez, Juan Pablo</creatorcontrib><creatorcontrib>Guzmán-Flores, Juan Manuel</creatorcontrib><creatorcontrib>Guzmán-González, Jesúa Ivan</creatorcontrib><creatorcontrib>Ramírez-De los Santos, Saúl</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De la Cruz-Ahumada, Claudia Jackelin</au><au>Topete-Reyes, Jorge Fernando</au><au>Mena-Ramírez, Juan Pablo</au><au>Guzmán-Flores, Juan Manuel</au><au>Guzmán-González, Jesúa Ivan</au><au>Ramírez-De los Santos, Saúl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients</atitle><jtitle>Journal of personalized medicine</jtitle><date>2023-08-27</date><risdate>2023</risdate><volume>13</volume><issue>9</issue><spage>1311</spage><pages>1311-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>Hemodialysis deteriorates patients’ physical, metabolic, and mental status. Clinical outcomes derived from inflammation determine a worse status but are less frequently identified. The objective of the study was to identify inflammatory determinants and the effect of SNP-related serum IL-6 and IL-10 levels on associated morbidity in hemodialysis. A sample of hemodialysis patients at IMSS Regional Hospital No.46 in Guadalajara (n = 85) were tested using the Malnutrition Inflammation Score (MIS) and Patient Health Questionnaire-9 (PHQ-9) to assess the associated morbidity. Serum cytokine levels were quantified by enzyme-linked immunosorbent assay (ELISA). The restriction fragment length polymorphism (RFLP) technique was used for analysis of IL-6-572C/G and IL-10-1082A/G. Using data visualization methods, we identified relevant determinants of inflammation. A simple regression model was constructed between predictors and targets with genotypes as covariates. Results showed malnutrition in 85.9% of patients and depressive symptoms in 50.6%. IL-10 was the most relevant inflammatory determinant, with regression coefficients (R2) between 0.05 and 0.11. The GG genotype of IL-10-1082 A/G evinced small effect on both clinical outcomes (δ of 0.35 and 0.37, respectively). Hemodialysis increases the associated morbidity, cytokines act as inflammatory determinants, and genetic variability contributes to the severity of clinical outcomes. Further studies need to refine the causal relationship between inflammation and CKD.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/jpm13091311</doi><orcidid>https://orcid.org/0000-0001-7695-0289</orcidid><orcidid>https://orcid.org/0000-0002-4673-112X</orcidid><orcidid>https://orcid.org/0000-0002-7433-1908</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2075-4426 |
| ispartof | Journal of personalized medicine, 2023-08, Vol.13 (9), p.1311 |
| issn | 2075-4426 2075-4426 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10532888 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Chronic kidney failure Clinical outcomes Cytokines Development and progression Enzyme-linked immunosorbent assay Enzymes Ethylenediaminetetraacetic acid Gene polymorphism Genetic testing Genetic variability Health aspects Hemodialysis Inflammation Interleukin 10 Interleukin 6 Kidney diseases Malnutrition Mental depression Mexico Morbidity Mortality Nutritional status Patients Polymorphism Precision medicine Questionnaires Restriction fragment length polymorphism Single-nucleotide polymorphism |
| title | Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T10%3A07%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inflammatory%20Determinants%20and%20Associated%20Morbidity%20in%20Hemodialysis%20Patients&rft.jtitle=Journal%20of%20personalized%20medicine&rft.au=De%20la%20Cruz-Ahumada,%20Claudia%20Jackelin&rft.date=2023-08-27&rft.volume=13&rft.issue=9&rft.spage=1311&rft.pages=1311-&rft.issn=2075-4426&rft.eissn=2075-4426&rft_id=info:doi/10.3390/jpm13091311&rft_dat=%3Cgale_pubme%3EA779739650%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2869393190&rft_id=info:pmid/&rft_galeid=A779739650&rfr_iscdi=true |