Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study
Background: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and...
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| Veröffentlicht in: | Journal of clinical medicine 2023-09, Vol.12 (18), p.5939 |
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| creator | Benoit-Piau, Justine Tremblay, Karine Piché, Alain Dallaire, Frédéric Bélanger, Mathieu d’Entremont, Marc-André Pasquier, Jean-Charles Fortin, Martin Bourque, Catherine Lapointe, Fanny Betala-Belinga, Jean-François Petit, Geneviève Jourdan, Guillaume Bahous, Renata Maya, Camilo Benzina, Amira Faiyaz Hossain, Muhammad Peel, Marie-Audrey Houle, Olivier Auger, Marie-Sandrine Rioux, Antoine Farand, Paul |
| description | Background: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. Objective: To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. Methods: This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. Results: A total of 1349 participants with a mean age of 46.6 ± 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). Conclusions: In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue. |
| doi_str_mv | 10.3390/jcm12185939 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10532279</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A779738917</galeid><sourcerecordid>A779738917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-69c9082ed60a4f526518b2b61e2e6688ac870172c8463be10c6cc3b8018962a93</originalsourceid><addsrcrecordid>eNptkktv1DAQxyMEElXpiS9giQsSSutH4gcXtIQWVlqplVq4Wo4zWbyK7SVOivbb16EVtKj2waPxb_7z0BTFW4JPGVP4bGc9oUTWiqkXxRHFQpSYSfbykf26OElph_ORsqJEHBW_NzFsyxsYPWpiSPBrhmAhodij5vLH-ktJFHIBXY3QRe-CCdNwQGvv5xCDcbeArszkIEzpI1qhxgTTObPgMe3BTn-AuJ-HDMVQfjYJOnQ9zd3hTfGqN0OCk4f3uPh-cX7TfCs3l1_XzWpT2qquppIrq7Ck0HFsqr6mvCaypS0nQIFzKY2VAhNBraw4a4Fgy61lrcREKk6NYsfFp3vd_dx66GwudTSD3o_Om_Ggo3H66U9wP_U23mqCa0apWBTePyiMMU8nTdq7ZGEYTIA4J02XCpgUgmb03X_oLs5jyP1liivGRVWrf9TWDKBd6GNObBdRvRJCCSYVEZk6fYbKtwPvbAzQu-x_EvDhPsDm4acR-r9NEqyXBdGPFoTdAZn_rE4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2869367459</pqid></control><display><type>article</type><title>Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study</title><source>Open Access: PubMed Central</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Benoit-Piau, Justine ; Tremblay, Karine ; Piché, Alain ; Dallaire, Frédéric ; Bélanger, Mathieu ; d’Entremont, Marc-André ; Pasquier, Jean-Charles ; Fortin, Martin ; Bourque, Catherine ; Lapointe, Fanny ; Betala-Belinga, Jean-François ; Petit, Geneviève ; Jourdan, Guillaume ; Bahous, Renata ; Maya, Camilo ; Benzina, Amira ; Faiyaz Hossain, Muhammad ; Peel, Marie-Audrey ; Houle, Olivier ; Auger, Marie-Sandrine ; Rioux, Antoine ; Farand, Paul</creator><creatorcontrib>Benoit-Piau, Justine ; Tremblay, Karine ; Piché, Alain ; Dallaire, Frédéric ; Bélanger, Mathieu ; d’Entremont, Marc-André ; Pasquier, Jean-Charles ; Fortin, Martin ; Bourque, Catherine ; Lapointe, Fanny ; Betala-Belinga, Jean-François ; Petit, Geneviève ; Jourdan, Guillaume ; Bahous, Renata ; Maya, Camilo ; Benzina, Amira ; Faiyaz Hossain, Muhammad ; Peel, Marie-Audrey ; Houle, Olivier ; Auger, Marie-Sandrine ; Rioux, Antoine ; Farand, Paul</creatorcontrib><description>Background: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. Objective: To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. Methods: This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. Results: A total of 1349 participants with a mean age of 46.6 ± 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). Conclusions: In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12185939</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age groups ; Asymptomatic ; Care and treatment ; Causes of ; Clinical medicine ; COVID-19 ; Data collection ; Diagnosis ; Disease ; Fatigue ; Infections ; Long COVID ; Medical personnel ; Mental disorders ; Mental health ; Population-based studies ; Public health ; Questionnaires ; Severe acute respiratory syndrome coronavirus 2 ; Stress (Psychology)</subject><ispartof>Journal of clinical medicine, 2023-09, Vol.12 (18), p.5939</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-69c9082ed60a4f526518b2b61e2e6688ac870172c8463be10c6cc3b8018962a93</citedby><cites>FETCH-LOGICAL-c454t-69c9082ed60a4f526518b2b61e2e6688ac870172c8463be10c6cc3b8018962a93</cites><orcidid>0009-0003-7140-0714 ; 0000-0002-1432-7384 ; 0000-0002-9874-3771 ; 0009-0000-6347-1190 ; 0000-0002-0489-2523 ; 0000-0002-2774-9738</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532279/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532279/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Benoit-Piau, Justine</creatorcontrib><creatorcontrib>Tremblay, Karine</creatorcontrib><creatorcontrib>Piché, Alain</creatorcontrib><creatorcontrib>Dallaire, Frédéric</creatorcontrib><creatorcontrib>Bélanger, Mathieu</creatorcontrib><creatorcontrib>d’Entremont, Marc-André</creatorcontrib><creatorcontrib>Pasquier, Jean-Charles</creatorcontrib><creatorcontrib>Fortin, Martin</creatorcontrib><creatorcontrib>Bourque, Catherine</creatorcontrib><creatorcontrib>Lapointe, Fanny</creatorcontrib><creatorcontrib>Betala-Belinga, Jean-François</creatorcontrib><creatorcontrib>Petit, Geneviève</creatorcontrib><creatorcontrib>Jourdan, Guillaume</creatorcontrib><creatorcontrib>Bahous, Renata</creatorcontrib><creatorcontrib>Maya, Camilo</creatorcontrib><creatorcontrib>Benzina, Amira</creatorcontrib><creatorcontrib>Faiyaz Hossain, Muhammad</creatorcontrib><creatorcontrib>Peel, Marie-Audrey</creatorcontrib><creatorcontrib>Houle, Olivier</creatorcontrib><creatorcontrib>Auger, Marie-Sandrine</creatorcontrib><creatorcontrib>Rioux, Antoine</creatorcontrib><creatorcontrib>Farand, Paul</creatorcontrib><title>Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study</title><title>Journal of clinical medicine</title><description>Background: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. Objective: To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. Methods: This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. Results: A total of 1349 participants with a mean age of 46.6 ± 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). Conclusions: In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue.</description><subject>Age groups</subject><subject>Asymptomatic</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Clinical medicine</subject><subject>COVID-19</subject><subject>Data collection</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Fatigue</subject><subject>Infections</subject><subject>Long COVID</subject><subject>Medical personnel</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Population-based studies</subject><subject>Public health</subject><subject>Questionnaires</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Stress 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collection</topic><topic>Diagnosis</topic><topic>Disease</topic><topic>Fatigue</topic><topic>Infections</topic><topic>Long COVID</topic><topic>Medical personnel</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Population-based studies</topic><topic>Public health</topic><topic>Questionnaires</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Stress (Psychology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benoit-Piau, Justine</creatorcontrib><creatorcontrib>Tremblay, Karine</creatorcontrib><creatorcontrib>Piché, Alain</creatorcontrib><creatorcontrib>Dallaire, Frédéric</creatorcontrib><creatorcontrib>Bélanger, Mathieu</creatorcontrib><creatorcontrib>d’Entremont, Marc-André</creatorcontrib><creatorcontrib>Pasquier, Jean-Charles</creatorcontrib><creatorcontrib>Fortin, Martin</creatorcontrib><creatorcontrib>Bourque, Catherine</creatorcontrib><creatorcontrib>Lapointe, 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benoit-Piau, Justine</au><au>Tremblay, Karine</au><au>Piché, Alain</au><au>Dallaire, Frédéric</au><au>Bélanger, Mathieu</au><au>d’Entremont, Marc-André</au><au>Pasquier, Jean-Charles</au><au>Fortin, Martin</au><au>Bourque, Catherine</au><au>Lapointe, Fanny</au><au>Betala-Belinga, Jean-François</au><au>Petit, Geneviève</au><au>Jourdan, Guillaume</au><au>Bahous, Renata</au><au>Maya, Camilo</au><au>Benzina, Amira</au><au>Faiyaz Hossain, Muhammad</au><au>Peel, Marie-Audrey</au><au>Houle, Olivier</au><au>Auger, Marie-Sandrine</au><au>Rioux, Antoine</au><au>Farand, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study</atitle><jtitle>Journal of clinical medicine</jtitle><date>2023-09-01</date><risdate>2023</risdate><volume>12</volume><issue>18</issue><spage>5939</spage><pages>5939-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: Lingering symptoms are frequently reported after acute SARS-CoV-2 infection, a condition known as post-COVID-19 condition (PCC). The duration and severity of PCC in immunologically naïve persons remain unclear. Furthermore, the long-term consequences of these chronic symptoms on work and mental health are poorly documented. Objective: To determine the outcome, the risk factors, and the impact on work and mental health associated with post-COVID-19 symptoms. Methods: This prospective population-based study assessed acute COVID-19 symptoms and their evolution for up to nine months following infection. Individuals aged 18 years and older with COVID-19 in three Canadian regions between 1 November 2020 and 31 May 2021 were recruited. Participants completed a questionnaire that was either administered by trained student investigators over the phone or self-administered online. Results: A total of 1349 participants with a mean age of 46.6 ± 16.0 years completed the questionnaire. Participants were mostly unvaccinated at the time of their COVID-19 episode (86.9%). Six hundred and twenty-two participants (48.0%) exhibited one symptom or more, at least three months post-COVID-19. Among participants with PCC, 23.0% to 37.8% experienced fatigue at the time of survey. Moreover, 6.1% expressed psychological distress. Risk factors for PCC and fatigue included female sex (OR = 1.996), higher number of symptoms (OR = 1.292), higher severity of episode (OR = 3.831), and having a mental health condition prior to the COVID-19 episode (OR = 5.155). Conclusions: In this multicenter cohort study, almost half (47%) of the participants reported persistent symptoms >3 months after acute infection. Baseline risk factors for PCC include female sex, number and severity of symptoms during acute infection, and a previous diagnosis of mental health disorder. Having PCC negatively impacted health-related quality of life and these patients were more likely to exhibit psychological distress, as well as fatigue.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/jcm12185939</doi><orcidid>https://orcid.org/0009-0003-7140-0714</orcidid><orcidid>https://orcid.org/0000-0002-1432-7384</orcidid><orcidid>https://orcid.org/0000-0002-9874-3771</orcidid><orcidid>https://orcid.org/0009-0000-6347-1190</orcidid><orcidid>https://orcid.org/0000-0002-0489-2523</orcidid><orcidid>https://orcid.org/0000-0002-2774-9738</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Asymptomatic Care and treatment Causes of Clinical medicine COVID-19 Data collection Diagnosis Disease Fatigue Infections Long COVID Medical personnel Mental disorders Mental health Population-based studies Public health Questionnaires Severe acute respiratory syndrome coronavirus 2 Stress (Psychology) |
| title | Long-Term Consequences of COVID-19 in Predominantly Immunonaive Patients: A Canadian Prospective Population-Based Study |
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