The astrocytic Na+‐HCO3− cotransporter, NBCe1, is dispensable for respiratory chemosensitivity

The interoceptive homeostatic mechanism that controls breathing, blood gases and acid‐base balance in response to changes in CO2/H+ is exquisitely sensitive, with convergent roles proposed for chemosensory brainstem neurons in the retrotrapezoid nucleus (RTN) and their supporting glial cells. For as...

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Veröffentlicht in:	The Journal of physiology 2023-08, Vol.601 (16), p.3667-3686
Hauptverfasser:	Li, Keyong, Gonye, Elizabeth C., Stornetta, Ruth L., Bayliss, Christopher B., Yi, Grace, Stornetta, Daniel S., Baca, Serapio M., Abbott, Stephen B.G., Guyenet, Patrice G., Bayliss, Douglas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification astrocyte Astrocytes Brain stem Carbon dioxide Cell activation Chemoreception chemosensors depolarization‐induced alkalosis electrogenic Gene deletion Glial cells Glial fibrillary acidic protein Hydrogen Hypoxia Neuronal-glial interactions Neurons Respiration retrotrapezoid Retrotrapezoid nucleus Slc4a4
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