CEST2022: Amide proton transfer-weighted MRI improves the diagnostic performance of multiparametric non-contrast-enhanced MRI techniques in patients with post-treatment high-grade gliomas
New or enlarged lesions in malignant gliomas after surgery and chemoradiation can be associated with tumor recurrence or treatment effect. Due to similar radiographic characteristics, conventional—and even some advanced MRI techniques—are limited in distinguishing these two pathologies. Amide proton...
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| Veröffentlicht in: | Magnetic resonance imaging 2023-10, Vol.102, p.222-228 |
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| creator | Huang, Qianqi Wu, Jingpu Le, Nhat Shen, Yiqing Guo, Pengfei Schreck, Karisa C. Kamson, David Blair, Lindsay Heo, Hye-Young Li, Xu Li, Wenbo Sair, Haris L. Blakeley, Jaishri O. Laterra, John Holdhoff, Matthias Grossman, Stuart A. Mukherjee, Debraj Bettegowda, Chetan van Zijl, Peter Zhou, Jinyuan Jiang, Shanshan |
| description | New or enlarged lesions in malignant gliomas after surgery and chemoradiation can be associated with tumor recurrence or treatment effect. Due to similar radiographic characteristics, conventional—and even some advanced MRI techniques—are limited in distinguishing these two pathologies. Amide proton transfer-weighted (APTw) MRI, a protein-based molecular imaging technique that does not require the administration of any exogenous contrast agent, was recently introduced into the clinical setting. In this study, we evaluated and compared the diagnostic performances of APTw MRI with several non-contrast-enhanced MRI sequences, such as diffusion-weighted imaging, susceptibility-weighted imaging, and pseudo-continuous arterial spin labeling. Thirty-nine scans from 28 glioma patients were obtained on a 3 T MRI scanner. A histogram analysis approach was employed to extract parameters from each tumor area. Statistically significant parameters (P |
| doi_str_mv | 10.1016/j.mri.2023.06.003 |
| format | Article |
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Due to similar radiographic characteristics, conventional—and even some advanced MRI techniques—are limited in distinguishing these two pathologies. Amide proton transfer-weighted (APTw) MRI, a protein-based molecular imaging technique that does not require the administration of any exogenous contrast agent, was recently introduced into the clinical setting. In this study, we evaluated and compared the diagnostic performances of APTw MRI with several non-contrast-enhanced MRI sequences, such as diffusion-weighted imaging, susceptibility-weighted imaging, and pseudo-continuous arterial spin labeling. Thirty-nine scans from 28 glioma patients were obtained on a 3 T MRI scanner. A histogram analysis approach was employed to extract parameters from each tumor area. Statistically significant parameters (P < 0.05) were selected to train multivariate logistic regression models to evaluate the performance of MRI sequences. Multiple histogram parameters, particularly from APTw and pseudo-continuous arterial spin labeling images, demonstrated significant differences between treatment effect and recurrent tumor. The regression model trained on the combination of all significant histogram parameters achieved the best result (area under the curve = 0.89). We found that APTw images added value to other advanced MR images for the differentiation of treatment effect and tumor recurrence.</description><identifier>ISSN: 0730-725X</identifier><identifier>ISSN: 1873-5894</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/j.mri.2023.06.003</identifier><identifier>PMID: 37321378</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Amide proton transfer-weighted imaging ; Amides ; Arterial spin labeling imaging ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - therapy ; Glioblastoma ; Glioma - diagnostic imaging ; Glioma - therapy ; Humans ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Neoplasm Recurrence, Local - diagnostic imaging ; Protons ; Treatment effect</subject><ispartof>Magnetic resonance imaging, 2023-10, Vol.102, p.222-228</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c404t-59845399b3affdfae8761a3729f929f1440e0d09b8037c61f4bd5a9f1cad8ba93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mri.2023.06.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37321378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Qianqi</creatorcontrib><creatorcontrib>Wu, Jingpu</creatorcontrib><creatorcontrib>Le, Nhat</creatorcontrib><creatorcontrib>Shen, Yiqing</creatorcontrib><creatorcontrib>Guo, Pengfei</creatorcontrib><creatorcontrib>Schreck, Karisa C.</creatorcontrib><creatorcontrib>Kamson, David</creatorcontrib><creatorcontrib>Blair, Lindsay</creatorcontrib><creatorcontrib>Heo, Hye-Young</creatorcontrib><creatorcontrib>Li, Xu</creatorcontrib><creatorcontrib>Li, Wenbo</creatorcontrib><creatorcontrib>Sair, Haris L.</creatorcontrib><creatorcontrib>Blakeley, Jaishri O.</creatorcontrib><creatorcontrib>Laterra, John</creatorcontrib><creatorcontrib>Holdhoff, Matthias</creatorcontrib><creatorcontrib>Grossman, Stuart A.</creatorcontrib><creatorcontrib>Mukherjee, Debraj</creatorcontrib><creatorcontrib>Bettegowda, Chetan</creatorcontrib><creatorcontrib>van Zijl, Peter</creatorcontrib><creatorcontrib>Zhou, Jinyuan</creatorcontrib><creatorcontrib>Jiang, Shanshan</creatorcontrib><title>CEST2022: Amide proton transfer-weighted MRI improves the diagnostic performance of multiparametric non-contrast-enhanced MRI techniques in patients with post-treatment high-grade gliomas</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>New or enlarged lesions in malignant gliomas after surgery and chemoradiation can be associated with tumor recurrence or treatment effect. Due to similar radiographic characteristics, conventional—and even some advanced MRI techniques—are limited in distinguishing these two pathologies. Amide proton transfer-weighted (APTw) MRI, a protein-based molecular imaging technique that does not require the administration of any exogenous contrast agent, was recently introduced into the clinical setting. In this study, we evaluated and compared the diagnostic performances of APTw MRI with several non-contrast-enhanced MRI sequences, such as diffusion-weighted imaging, susceptibility-weighted imaging, and pseudo-continuous arterial spin labeling. Thirty-nine scans from 28 glioma patients were obtained on a 3 T MRI scanner. A histogram analysis approach was employed to extract parameters from each tumor area. Statistically significant parameters (P < 0.05) were selected to train multivariate logistic regression models to evaluate the performance of MRI sequences. Multiple histogram parameters, particularly from APTw and pseudo-continuous arterial spin labeling images, demonstrated significant differences between treatment effect and recurrent tumor. The regression model trained on the combination of all significant histogram parameters achieved the best result (area under the curve = 0.89). We found that APTw images added value to other advanced MR images for the differentiation of treatment effect and tumor recurrence.</description><subject>Amide proton transfer-weighted imaging</subject><subject>Amides</subject><subject>Arterial spin labeling imaging</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - therapy</subject><subject>Glioblastoma</subject><subject>Glioma - diagnostic imaging</subject><subject>Glioma - therapy</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Neoplasm Recurrence, Local - diagnostic imaging</subject><subject>Protons</subject><subject>Treatment effect</subject><issn>0730-725X</issn><issn>1873-5894</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEokvhAbggH7k42HH-wgFVqwKVipCgSNwsx5lsvIrtYHu34tn6cky0pYILB8uSv29-npkvy15ylnPG6zf73AaTF6wQOatzxsSjbMPbRtCq7crH2YY1gtGmqH6cZc9i3DPGqkJUT7Mz0YiCi6bdZHfby283SCjekgtrBiBL8Mk7koJycYRAb8HspgQD-fz1ihiL8hEiSROQwaid8zEZTRYIow9WOQ3Ej8Qe5mQWFZSFFFB23lHtHTJjouCm1XcCJtCTMz8PiDSOLCoZcCmSW5MmsiCbpgAqWXwkE_ZBd0Fhj7vZeKvi8-zJqOYIL-7v8-z7h8ub7Sd6_eXj1fbimuqSlYlWXVtWout6ocZxGBW0Tc2VaIpu7PDwsmTABtb1LRONrvlY9kOlUNBqaHvVifPs_Ym7HHoLg4Z1klkuwVgVfkmvjPxXcWaSO3-UHPfdFhVHwut7QvDrsElaEzXMs3LgD1GiC2Nq24ahlZ-sOvgYA4wP_3Am19TlXmLqck1dslpi6ljz6u8GHyr-xIyGdycD4JqOBoKMGjeNKZgAOsnBm__gfwPfesMz</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Huang, Qianqi</creator><creator>Wu, Jingpu</creator><creator>Le, Nhat</creator><creator>Shen, Yiqing</creator><creator>Guo, Pengfei</creator><creator>Schreck, Karisa C.</creator><creator>Kamson, David</creator><creator>Blair, Lindsay</creator><creator>Heo, Hye-Young</creator><creator>Li, Xu</creator><creator>Li, Wenbo</creator><creator>Sair, Haris L.</creator><creator>Blakeley, Jaishri O.</creator><creator>Laterra, John</creator><creator>Holdhoff, Matthias</creator><creator>Grossman, Stuart A.</creator><creator>Mukherjee, Debraj</creator><creator>Bettegowda, Chetan</creator><creator>van Zijl, Peter</creator><creator>Zhou, Jinyuan</creator><creator>Jiang, Shanshan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20231001</creationdate><title>CEST2022: Amide proton transfer-weighted MRI improves the diagnostic performance of multiparametric non-contrast-enhanced MRI techniques in patients with post-treatment high-grade gliomas</title><author>Huang, Qianqi ; Wu, Jingpu ; Le, Nhat ; Shen, Yiqing ; Guo, Pengfei ; Schreck, Karisa C. ; Kamson, David ; Blair, Lindsay ; Heo, Hye-Young ; Li, Xu ; Li, Wenbo ; Sair, Haris L. ; Blakeley, Jaishri O. ; Laterra, John ; Holdhoff, Matthias ; Grossman, Stuart A. ; Mukherjee, Debraj ; Bettegowda, Chetan ; van Zijl, Peter ; Zhou, Jinyuan ; Jiang, Shanshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-59845399b3affdfae8761a3729f929f1440e0d09b8037c61f4bd5a9f1cad8ba93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amide proton transfer-weighted imaging</topic><topic>Amides</topic><topic>Arterial spin labeling imaging</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - therapy</topic><topic>Glioblastoma</topic><topic>Glioma - diagnostic imaging</topic><topic>Glioma - therapy</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Neoplasm Recurrence, Local - diagnostic imaging</topic><topic>Protons</topic><topic>Treatment effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Qianqi</creatorcontrib><creatorcontrib>Wu, Jingpu</creatorcontrib><creatorcontrib>Le, Nhat</creatorcontrib><creatorcontrib>Shen, Yiqing</creatorcontrib><creatorcontrib>Guo, Pengfei</creatorcontrib><creatorcontrib>Schreck, Karisa C.</creatorcontrib><creatorcontrib>Kamson, David</creatorcontrib><creatorcontrib>Blair, Lindsay</creatorcontrib><creatorcontrib>Heo, Hye-Young</creatorcontrib><creatorcontrib>Li, Xu</creatorcontrib><creatorcontrib>Li, Wenbo</creatorcontrib><creatorcontrib>Sair, Haris L.</creatorcontrib><creatorcontrib>Blakeley, Jaishri O.</creatorcontrib><creatorcontrib>Laterra, John</creatorcontrib><creatorcontrib>Holdhoff, Matthias</creatorcontrib><creatorcontrib>Grossman, Stuart A.</creatorcontrib><creatorcontrib>Mukherjee, Debraj</creatorcontrib><creatorcontrib>Bettegowda, Chetan</creatorcontrib><creatorcontrib>van Zijl, Peter</creatorcontrib><creatorcontrib>Zhou, Jinyuan</creatorcontrib><creatorcontrib>Jiang, Shanshan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Qianqi</au><au>Wu, Jingpu</au><au>Le, Nhat</au><au>Shen, Yiqing</au><au>Guo, Pengfei</au><au>Schreck, Karisa C.</au><au>Kamson, David</au><au>Blair, Lindsay</au><au>Heo, Hye-Young</au><au>Li, Xu</au><au>Li, Wenbo</au><au>Sair, Haris L.</au><au>Blakeley, Jaishri O.</au><au>Laterra, John</au><au>Holdhoff, Matthias</au><au>Grossman, Stuart A.</au><au>Mukherjee, Debraj</au><au>Bettegowda, Chetan</au><au>van Zijl, Peter</au><au>Zhou, Jinyuan</au><au>Jiang, Shanshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CEST2022: Amide proton transfer-weighted MRI improves the diagnostic performance of multiparametric non-contrast-enhanced MRI techniques in patients with post-treatment high-grade gliomas</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>102</volume><spage>222</spage><epage>228</epage><pages>222-228</pages><issn>0730-725X</issn><issn>1873-5894</issn><eissn>1873-5894</eissn><abstract>New or enlarged lesions in malignant gliomas after surgery and chemoradiation can be associated with tumor recurrence or treatment effect. Due to similar radiographic characteristics, conventional—and even some advanced MRI techniques—are limited in distinguishing these two pathologies. Amide proton transfer-weighted (APTw) MRI, a protein-based molecular imaging technique that does not require the administration of any exogenous contrast agent, was recently introduced into the clinical setting. In this study, we evaluated and compared the diagnostic performances of APTw MRI with several non-contrast-enhanced MRI sequences, such as diffusion-weighted imaging, susceptibility-weighted imaging, and pseudo-continuous arterial spin labeling. Thirty-nine scans from 28 glioma patients were obtained on a 3 T MRI scanner. A histogram analysis approach was employed to extract parameters from each tumor area. Statistically significant parameters (P < 0.05) were selected to train multivariate logistic regression models to evaluate the performance of MRI sequences. Multiple histogram parameters, particularly from APTw and pseudo-continuous arterial spin labeling images, demonstrated significant differences between treatment effect and recurrent tumor. The regression model trained on the combination of all significant histogram parameters achieved the best result (area under the curve = 0.89). We found that APTw images added value to other advanced MR images for the differentiation of treatment effect and tumor recurrence.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>37321378</pmid><doi>10.1016/j.mri.2023.06.003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amide proton transfer-weighted imaging Amides Arterial spin labeling imaging Brain Neoplasms - diagnostic imaging Brain Neoplasms - therapy Glioblastoma Glioma - diagnostic imaging Glioma - therapy Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Neoplasm Recurrence, Local - diagnostic imaging Protons Treatment effect |
| title | CEST2022: Amide proton transfer-weighted MRI improves the diagnostic performance of multiparametric non-contrast-enhanced MRI techniques in patients with post-treatment high-grade gliomas |
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