A study of the interaction of alcohol drinking and tobacco smoking among French cases of laryngeal cancer
Laryngeal cancer represents an important cause of cancer in France, and the individual effects of alcohol and tobacco on this cancer site are well known. However the problem of the interaction between these agents is less extensively documented, and the role of the high consumptions of alcohol has n...
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| Veröffentlicht in: | Journal of epidemiology and community health (1979) 1988-12, Vol.42 (4), p.350-354 |
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| container_title | Journal of epidemiology and community health (1979) |
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| creator | Guénel, P Chastang, J F Luce, D Leclerc, A Brugère, J |
| description | Laryngeal cancer represents an important cause of cancer in France, and the individual effects of alcohol and tobacco on this cancer site are well known. However the problem of the interaction between these agents is less extensively documented, and the role of the high consumptions of alcohol has not been studied frequently. A case-control analysis was undertaken to investigate the joint effect of alcohol and tobacco by comparing 197 glottic and 214 supraglottic cancer cases to 4135 controls representative of the French general population. Heavy drinkers were available from the two groups of cases, the highest alcohol category being equivalent to a consumption of more than 2 litres of wine per day. The relative risks estimated for heavy drinkers and smokers were high, and the results indicated an even stronger effect of alcohol drinking and tobacco smoking on the upper part of the laryngeal region. Additive and multiplicative models were fitted to the data. The multiplicative hypothesis was found to be the most appropriate, implying that the risks associated with alcohol and tobacco multiply when the exposures occur simultaneously. The public health implications of this result and the contribution of heavy drinkers and smokers to the frequency of upper respiratory and digestive tract cancers are discussed. |
| doi_str_mv | 10.1136/jech.42.4.350 |
| format | Article |
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However the problem of the interaction between these agents is less extensively documented, and the role of the high consumptions of alcohol has not been studied frequently. A case-control analysis was undertaken to investigate the joint effect of alcohol and tobacco by comparing 197 glottic and 214 supraglottic cancer cases to 4135 controls representative of the French general population. Heavy drinkers were available from the two groups of cases, the highest alcohol category being equivalent to a consumption of more than 2 litres of wine per day. The relative risks estimated for heavy drinkers and smokers were high, and the results indicated an even stronger effect of alcohol drinking and tobacco smoking on the upper part of the laryngeal region. Additive and multiplicative models were fitted to the data. The multiplicative hypothesis was found to be the most appropriate, implying that the risks associated with alcohol and tobacco multiply when the exposures occur simultaneously. The public health implications of this result and the contribution of heavy drinkers and smokers to the frequency of upper respiratory and digestive tract cancers are discussed.</description><identifier>ISSN: 0143-005X</identifier><identifier>EISSN: 1470-2738</identifier><identifier>DOI: 10.1136/jech.42.4.350</identifier><identifier>PMID: 3256577</identifier><identifier>CODEN: JECHDR</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Alcohol Drinking ; Alcoholic beverages ; Alcohols ; Carcinoma, Squamous Cell - etiology ; Control groups ; Ethanol ; Female ; France ; Glottis ; Humans ; Laryngeal cancer ; Laryngeal Neoplasms - etiology ; Larynx ; Male ; Middle Aged ; Modeling ; Public health ; Risk Factors ; Smoking - adverse effects ; Tobacco ; Tobacco smoking ; Wines</subject><ispartof>Journal of epidemiology and community health (1979), 1988-12, Vol.42 (4), p.350-354</ispartof><rights>Copyright 1988 The Journal of Epidemiology and Community Health</rights><rights>Copyright BMJ Publishing Group LTD Dec 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b503t-d30e6df5b64d89ac8dabdce7e840a5491bf30bba58a8f89c3e9d85ffeeff52023</citedby><cites>FETCH-LOGICAL-b503t-d30e6df5b64d89ac8dabdce7e840a5491bf30bba58a8f89c3e9d85ffeeff52023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25566877$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25566877$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,725,778,782,801,883,27907,27908,53774,53776,58000,58233</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3256577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guénel, P</creatorcontrib><creatorcontrib>Chastang, J F</creatorcontrib><creatorcontrib>Luce, D</creatorcontrib><creatorcontrib>Leclerc, A</creatorcontrib><creatorcontrib>Brugère, J</creatorcontrib><title>A study of the interaction of alcohol drinking and tobacco smoking among French cases of laryngeal cancer</title><title>Journal of epidemiology and community health (1979)</title><addtitle>J Epidemiol Community Health</addtitle><description>Laryngeal cancer represents an important cause of cancer in France, and the individual effects of alcohol and tobacco on this cancer site are well known. However the problem of the interaction between these agents is less extensively documented, and the role of the high consumptions of alcohol has not been studied frequently. A case-control analysis was undertaken to investigate the joint effect of alcohol and tobacco by comparing 197 glottic and 214 supraglottic cancer cases to 4135 controls representative of the French general population. Heavy drinkers were available from the two groups of cases, the highest alcohol category being equivalent to a consumption of more than 2 litres of wine per day. The relative risks estimated for heavy drinkers and smokers were high, and the results indicated an even stronger effect of alcohol drinking and tobacco smoking on the upper part of the laryngeal region. Additive and multiplicative models were fitted to the data. The multiplicative hypothesis was found to be the most appropriate, implying that the risks associated with alcohol and tobacco multiply when the exposures occur simultaneously. The public health implications of this result and the contribution of heavy drinkers and smokers to the frequency of upper respiratory and digestive tract cancers are discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Carcinoma, Squamous Cell - etiology</subject><subject>Control groups</subject><subject>Ethanol</subject><subject>Female</subject><subject>France</subject><subject>Glottis</subject><subject>Humans</subject><subject>Laryngeal cancer</subject><subject>Laryngeal Neoplasms - etiology</subject><subject>Larynx</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Modeling</subject><subject>Public health</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Tobacco</subject><subject>Tobacco smoking</subject><subject>Wines</subject><issn>0143-005X</issn><issn>1470-2738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkduL1DAUxoMo67j66KNQEMSXjmkuTfoi7A6uCouKN3wLaXoybbdNdpNU3P_ejDOMlxdfknC-3znnCx9Cjyu8ripavxjB9GtG1mxNOb6DVhUTuCSCyrtohStGS4z5t_voQYwjzk9BmhN0QgmvuRArNJwVMS3dbeFtkXooBpcgaJMG73YlPRnf-6nowuCuBrcttOuK5FttjC_i7Pe12efzIoAzfWF0hLhrnXS4dVvQUy45A-Ehumf1FOHR4T5FXy5efd68KS_fv367ObssW45pKjuKoe4sb2vWyUYb2em2MyBAMqw5a6rWUty2mkstrWwMhaaT3FoAaznBhJ6il_u510s7Q251KehJXYdhzo6U14P6W3FDr7b-u6owJ6JmecCzw4DgbxaISc1DNDBN2oFfohJSNAJzmsGn_4CjX4LLn1OVEIxLwrHMVLmnTPAxBrBHKxVWuwTVLkHFiGIqJ5j5J3_6P9KHyH7rY0w-HGXCeV3LX_ph3xAT_DjqOlypWlDB1buvG_WJyPMPhH9U55l_vufbefyPtZ88Fr-5</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>Guénel, P</creator><creator>Chastang, J F</creator><creator>Luce, D</creator><creator>Leclerc, A</creator><creator>Brugère, J</creator><general>BMJ Publishing Group Ltd</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19881201</creationdate><title>A study of the interaction of alcohol drinking and tobacco smoking among French cases of laryngeal cancer</title><author>Guénel, P ; 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However the problem of the interaction between these agents is less extensively documented, and the role of the high consumptions of alcohol has not been studied frequently. A case-control analysis was undertaken to investigate the joint effect of alcohol and tobacco by comparing 197 glottic and 214 supraglottic cancer cases to 4135 controls representative of the French general population. Heavy drinkers were available from the two groups of cases, the highest alcohol category being equivalent to a consumption of more than 2 litres of wine per day. The relative risks estimated for heavy drinkers and smokers were high, and the results indicated an even stronger effect of alcohol drinking and tobacco smoking on the upper part of the laryngeal region. Additive and multiplicative models were fitted to the data. The multiplicative hypothesis was found to be the most appropriate, implying that the risks associated with alcohol and tobacco multiply when the exposures occur simultaneously. The public health implications of this result and the contribution of heavy drinkers and smokers to the frequency of upper respiratory and digestive tract cancers are discussed.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>3256577</pmid><doi>10.1136/jech.42.4.350</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0143-005X |
| ispartof | Journal of epidemiology and community health (1979), 1988-12, Vol.42 (4), p.350-354 |
| issn | 0143-005X 1470-2738 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Alcohol Drinking Alcoholic beverages Alcohols Carcinoma, Squamous Cell - etiology Control groups Ethanol Female France Glottis Humans Laryngeal cancer Laryngeal Neoplasms - etiology Larynx Male Middle Aged Modeling Public health Risk Factors Smoking - adverse effects Tobacco Tobacco smoking Wines |
| title | A study of the interaction of alcohol drinking and tobacco smoking among French cases of laryngeal cancer |
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