Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression

Prostate cancer progression to the lethal metastatic castration-resistant phenotype (mCRPC) is driven by αv integrins and is associated with Golgi disorganization and activation of the ATF6 branch of unfolded protein response (UPR). Overexpression of integrins requires N-acetylglucosaminyltransferas...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular cancer research 2023-09, Vol.21 (9), p.958-974
Hauptverfasser:	Macke, Amanda J, Pachikov, Artem N, Divita, Taylor E, Morris, Mary E, LaGrange, Chad A, Holzapfel, Melissa S, Kubyshkin, Anatoly V, Zyablitskaya, Evgeniya Y, Makalish, Tatiana P, Eremenko, Sergey N, Qiu, Haowen, Riethoven, Jean-Jack M, Hemstreet, George P, Petrosyan, Armen
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Autophagy Endoplasmic Reticulum Stress Humans Integrin alphaV Integrins Male N-Acetylglucosaminyltransferases Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!