Inhibition of talin-induced integrin activation by a double-hit stapled peptide

Integrins are ubiquitously expressed cell-adhesion proteins. Activation of integrins is triggered by talin through an inside-out signaling pathway, which can be driven by RAP1-interacting adaptor molecule (RIAM) through its interaction with talin at two distinct sites. A helical talin-binding segmen...

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Veröffentlicht in:	Structure (London) 2023-08, Vol.31 (8), p.948-957.e3
Hauptverfasser:	Gao, Tong, Cho, Eun-ah, Zhang, Pingfeng, Wu, Jinhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry crystal structure integrin Integrins - metabolism Membrane Proteins - chemistry Peptides - metabolism Peptides - pharmacology peptidomimetic inhibitor Peptidomimetics - pharmacology RIAM stapled peptide talin Talin - chemistry
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