YTHDF2 inhibition potentiates radiotherapy anti-tumor efficacy

RNA N 6 -methyladenosine (m 6 A) modification is implicated in cancer progression. However, the impact of m 6 A on the anti-tumor effects of radiotherapy and the related mechanisms are unknown. Here we show that ionizing radiation (IR) induces immunosuppressive myeloid-derived suppressor cell (MDSC)...

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Veröffentlicht in:	Cancer cell 2023-05, Vol.41 (7), p.1294-1308.e8
Hauptverfasser:	Wang, Liangliang, Dou, Xiaoyang, Chen, Shijie, Yu, Xianbin, Huang, Xiaona, Zhang, Linda, Chen, Yantao, Wang, Jiaai, Yang, Kaiting, Bugno, Jason, Pitroda, Sean, Ding, Xingchen, Piffko, Andras, Si, Wei, Chen, Chao, Jiang, Hualiang, Zhou, Bing, Chmura, Steven J., Luo, Cheng, Liang, Hua Laura, He, Chuan, Weichselbaum, Ralph R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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