Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death

TAK1 is a key modulator of both NF-κB signaling and RIPK1. In TNF signaling pathway, activation of TAK1 directly mediates the phosphorylation of IKK complex and RIPK1. In a search for small molecule activators of RIPK1-mediated necroptosis, we found R406/R788, two small molecule analogs that could p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-09, Vol.120 (39), p.e2308079120-e2308079120
Hauptverfasser:	Sun, Weimin, Wu, Guowei, Tian, Xinyu, Qi, Chunting, Liu, Jingli, Tong, Yilun, Zhang, Mengmeng, Gao, Jiayang, Cao, Ze, Zhang, Yuchao, Liu, Zhijun, Tian, Xiaoxu, Wu, Ping, Peng, Chao, Li, Jingwen, Tan, Li, Shan, Bing, Liu, Jianping, Li, Ying, Yuan, Junying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anticancer properties Apoptosis Binding Biological Sciences Cell Death Chemical synthesis Cytosol Kinases Mice Necroptosis Neoplasms - drug therapy Neoplasms - genetics NF-κB protein Phosphorylation Signal transduction Syk protein TAK1 protein Tumor necrosis factor Ubiquitination
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