Recovering the susceptibility of antibiotic-resistant bacteria using photooxidative damage
Multidrug-resistant bacteria are one of the most serious threats to infection control. Few new antibiotics have been developed; however, the lack of an effective new mechanism of their action has worsened the situation. Photodynamic inactivation (PDI) can break antimicrobial resistance, since it pot...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2023-09, Vol.120 (39), p.e2311667120-e2311667120 |
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| creator | Soares, Jennifer M. Yakovlev, Vladislav V. Blanco, Kate C. Bagnato, Vanderlei S. |
| description | Multidrug-resistant bacteria are one of the most serious threats to infection control. Few new antibiotics have been developed; however, the lack of an effective new mechanism of their action has worsened the situation. Photodynamic inactivation (PDI) can break antimicrobial resistance, since it potentiates the effect of antibiotics, and induces oxidative stress in microorganisms through the interaction of light with a photosensitizer. This paper addresses the application of PDI for increasing bacterial susceptibility to antibiotics and helping in bacterial persistence and virulence. The effect of photodynamic action on resistant bacteria collected from patients and bacteria cells with induced resistance in the laboratory was investigated.
Staphylococcus aureus
resistance breakdown levels for each antibiotic (amoxicillin, erythromycin, and gentamicin) from the photodynamic effect (10 µM curcumin, 10 J/cm
2
) and its maintenance in descendant microorganisms were demonstrated within five cycles after PDI application. PDI showed an innovative feature for modifying the degree of bacterial sensitivity to antibiotics according to dosages, thus reducing resistance and persistence of microorganisms from standard and clinical strains. We hypothesize a reduction in the degree of antimicrobial resistance through photooxidative action combats antibiotic failures. |
| doi_str_mv | 10.1073/pnas.2311667120 |
| format | Article |
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Staphylococcus aureus
resistance breakdown levels for each antibiotic (amoxicillin, erythromycin, and gentamicin) from the photodynamic effect (10 µM curcumin, 10 J/cm
2
) and its maintenance in descendant microorganisms were demonstrated within five cycles after PDI application. PDI showed an innovative feature for modifying the degree of bacterial sensitivity to antibiotics according to dosages, thus reducing resistance and persistence of microorganisms from standard and clinical strains. We hypothesize a reduction in the degree of antimicrobial resistance through photooxidative action combats antibiotic failures.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.2311667120</identifier><identifier>PMID: 37729197</identifier><language>eng</language><publisher>Washington: National Academy of Sciences</publisher><subject>Amoxicillin ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Antimicrobial resistance ; Bacteria ; Biological Sciences ; Curcumin ; Drug resistance ; Erythromycin ; Gentamicin ; Inactivation ; Microorganisms ; Multidrug resistance ; Oxidation resistance ; Oxidative stress ; Virulence</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2023-09, Vol.120 (39), p.e2311667120-e2311667120</ispartof><rights>Copyright National Academy of Sciences Sep 26, 2023</rights><rights>Copyright © 2023 the Author(s). Published by PNAS. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-c698f38b379fcac745ed2d9348059201ff9a481d19498d043dbd4e326c36b2c13</citedby><cites>FETCH-LOGICAL-c399t-c698f38b379fcac745ed2d9348059201ff9a481d19498d043dbd4e326c36b2c13</cites><orcidid>0000-0002-4557-1013 ; 0000-0002-2978-7076 ; 0000-0003-0361-9725 ; 0000-0003-4833-239X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523486/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523486/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Soares, Jennifer M.</creatorcontrib><creatorcontrib>Yakovlev, Vladislav V.</creatorcontrib><creatorcontrib>Blanco, Kate C.</creatorcontrib><creatorcontrib>Bagnato, Vanderlei S.</creatorcontrib><title>Recovering the susceptibility of antibiotic-resistant bacteria using photooxidative damage</title><title>Proceedings of the National Academy of Sciences - PNAS</title><description>Multidrug-resistant bacteria are one of the most serious threats to infection control. Few new antibiotics have been developed; however, the lack of an effective new mechanism of their action has worsened the situation. Photodynamic inactivation (PDI) can break antimicrobial resistance, since it potentiates the effect of antibiotics, and induces oxidative stress in microorganisms through the interaction of light with a photosensitizer. This paper addresses the application of PDI for increasing bacterial susceptibility to antibiotics and helping in bacterial persistence and virulence. The effect of photodynamic action on resistant bacteria collected from patients and bacteria cells with induced resistance in the laboratory was investigated.
Staphylococcus aureus
resistance breakdown levels for each antibiotic (amoxicillin, erythromycin, and gentamicin) from the photodynamic effect (10 µM curcumin, 10 J/cm
2
) and its maintenance in descendant microorganisms were demonstrated within five cycles after PDI application. PDI showed an innovative feature for modifying the degree of bacterial sensitivity to antibiotics according to dosages, thus reducing resistance and persistence of microorganisms from standard and clinical strains. We hypothesize a reduction in the degree of antimicrobial resistance through photooxidative action combats antibiotic failures.</description><subject>Amoxicillin</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial resistance</subject><subject>Bacteria</subject><subject>Biological Sciences</subject><subject>Curcumin</subject><subject>Drug resistance</subject><subject>Erythromycin</subject><subject>Gentamicin</subject><subject>Inactivation</subject><subject>Microorganisms</subject><subject>Multidrug resistance</subject><subject>Oxidation resistance</subject><subject>Oxidative stress</subject><subject>Virulence</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdUU1LxDAQDaLo-nH2WvDipTr5aNOcRMQvEATRi5eQJulupNvUJF3035tVUfQ0zMybNzPvIXSI4QQDp6fjoOIJoRjXNccENtAMg8BlzQRsohkA4WXDCNtBuzG-AICoGthGO5RzIrDgM_T8YLVf2eCGeZEWtohT1HZMrnW9S--F7wo1rDOfnC6DjS6mXChapVMeUsUU15Pjwifv35xRya1sYdRSze0-2upUH-3Bd9xDT1eXjxc35d399e3F-V2pqRCp1LVoOtq0lItOK81ZZQ0xgrIGKkEAd51QrMEGCyYaA4ya1jBLSa1p3RKN6R46--Idp3ZpjbZDCqqXY3BLFd6lV07-7QxuIed-JTFUJK-pM8PxN0Pwr5ONSS5dlqHv1WD9FCVpsroVzcpm6NE_6IufwpD_yygOWWvySXj6hdLBxxhs93MNBrk2Tq6Nk7_G0Q-Qaoyc</recordid><startdate>20230926</startdate><enddate>20230926</enddate><creator>Soares, Jennifer M.</creator><creator>Yakovlev, Vladislav V.</creator><creator>Blanco, Kate C.</creator><creator>Bagnato, Vanderlei S.</creator><general>National Academy of Sciences</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4557-1013</orcidid><orcidid>https://orcid.org/0000-0002-2978-7076</orcidid><orcidid>https://orcid.org/0000-0003-0361-9725</orcidid><orcidid>https://orcid.org/0000-0003-4833-239X</orcidid></search><sort><creationdate>20230926</creationdate><title>Recovering the susceptibility of antibiotic-resistant bacteria using photooxidative damage</title><author>Soares, Jennifer M. ; 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Staphylococcus aureus
resistance breakdown levels for each antibiotic (amoxicillin, erythromycin, and gentamicin) from the photodynamic effect (10 µM curcumin, 10 J/cm
2
) and its maintenance in descendant microorganisms were demonstrated within five cycles after PDI application. PDI showed an innovative feature for modifying the degree of bacterial sensitivity to antibiotics according to dosages, thus reducing resistance and persistence of microorganisms from standard and clinical strains. We hypothesize a reduction in the degree of antimicrobial resistance through photooxidative action combats antibiotic failures.</abstract><cop>Washington</cop><pub>National Academy of Sciences</pub><pmid>37729197</pmid><doi>10.1073/pnas.2311667120</doi><orcidid>https://orcid.org/0000-0002-4557-1013</orcidid><orcidid>https://orcid.org/0000-0002-2978-7076</orcidid><orcidid>https://orcid.org/0000-0003-0361-9725</orcidid><orcidid>https://orcid.org/0000-0003-4833-239X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amoxicillin Antibiotic resistance Antibiotics Antimicrobial agents Antimicrobial resistance Bacteria Biological Sciences Curcumin Drug resistance Erythromycin Gentamicin Inactivation Microorganisms Multidrug resistance Oxidation resistance Oxidative stress Virulence |
| title | Recovering the susceptibility of antibiotic-resistant bacteria using photooxidative damage |
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