Measuring prion propagation in single bacteria elucidates a mechanism of loss

Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathies in mammals, but prions can also constitute nontoxic protein-based elements of inheritance in fungi a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-09, Vol.120 (39), p.e2221539120-e2221539120
Hauptverfasser:	Jager, Krista, Orozco-Hidalgo, Maria Teresa, Springstein, Benjamin Lennart, Joly-Smith, Euan, Papazotos, Fotini, McDonough, EmilyKate, Fleming, Eleanor, McCallum, Giselle, Yuan, Andy H, Hilfinger, Andreas, Hochschild, Ann, Potvin-Trottier, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Animals Bacteria Biological Sciences Cell Division Fluorescence microscopy Inheritance Patterns Mammals Microfluidics Physical Sciences Prion protein Prions Prokaryotes Prokaryotic Cells Propagation Proteins Saccharomyces cerevisiae Self propagation Transmissible spongiform encephalopathy Yeast Yeasts
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