A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking

Calcium signaling is critical for successful fertilization. In spermatozoa, calcium influx into the sperm flagella mediated by the sperm-specific CatSper calcium channel is necessary for hyperactivated motility and male fertility. CatSper is a macromolecular complex and is repeatedly arranged in zig...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-09, Vol.120 (39), p.e2304409120-e2304409120
Hauptverfasser:	Huang, Xiaofang, Miyata, Haruhiko, Wang, Huafeng, Mori, Giulia, Iida-Norita, Rie, Ikawa, Masahito, Percudani, Riccardo, Chung, Jean-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Assembly Biological Sciences Calcium Calcium channels Calcium influx Calcium signalling Cell Membrane Dimers Fertility Fertilization Flagella Ion Channels Macromolecules Male Males Membrane Proteins - genetics Mice Motility Pore formation Proteins Semen Seminal Plasma Proteins Sperm Sperm Motility - genetics Sperm Tail Spermatogenesis Spermatozoa
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