Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach
Abstract Introduction: Gastric metastases are quite infrequent. When arising from testicular germ cell tumors, gastric metastases are usually associated with nonseminomas. Case Report: A 45-year-old man presented with upper gastrointestinal bleeding, severe anemia, and elevated lactate dehydrogenase...
Gespeichert in:
| Veröffentlicht in: | GE Portuguese journal of gastroenterology 2023-08, Vol.30 (4), p.311-315 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 315 |
|---|---|
| container_issue | 4 |
| container_start_page | 311 |
| container_title | GE Portuguese journal of gastroenterology |
| container_volume | 30 |
| creator | Silva, Maria Azevedo Leal, Carina Ruge, André Fernandes, Alexandra Cunha, Maria Fernanda Vasconcelos, Helena |
| description | Abstract
Introduction: Gastric metastases are quite infrequent. When arising from testicular germ cell tumors, gastric metastases are usually associated with nonseminomas. Case Report: A 45-year-old man presented with upper gastrointestinal bleeding, severe anemia, and elevated lactate dehydrogenase. Endoscopy revealed three atypical-looking gastric ulcers. Abdominal computed tomography showed an extensive heterogeneous retroperitoneal mass and a smaller one in the pelvis. Biopsies of both the ulcers and the retroperitoneal mass revealed a highly proliferative neoplasia of unknown origin. While the diagnostic work up was taking place, the patient complained of a testicular mass which was resected, after suspicious findings in the ultrasound. Histopathologic findings revealed a testicular seminoma. Revision of previous biopsies was compatible with metastatic seminoma to the stomach and the retroperitoneum. Discussion/Conclusion: Gastric metastasis arising from testicular seminoma is quite infrequent and usually diagnosed after the primary tumor is known. We report a rare case of a testicular seminoma presenting as upper gastrointestinal bleeding due to gastric metastases. This case highlights the importance of detailed anamnesis and physical examination in the differential diagnosis of atypical gastric ulcers with initial inconclusive work up and emphasizes an unusual manifestation of a germ cell malignancy. |
| doi_str_mv | 10.1159/000526427 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10521319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A760266178</galeid><doaj_id>oai_doaj_org_article_c039273dbe7345a4afaaef87f769ce05</doaj_id><sourcerecordid>A760266178</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-46879ca8c88d696b775979cf4424e8c6e82bc3cb63b4c10ea47add9e3f4a6b333</originalsourceid><addsrcrecordid>eNptkkFv1DAQhSMEolXpgTsHSz1xSLFjx465oGWBpaiIipazNXHGWZdsvNgJEv8eL6lWqoR8sPXmzefRzBTFS0YvGav1G0ppXUlRqSfFacUbVTJdi6eHt2ClqEV9Upyn5FtaU8VlI6vnxQlXSipO1Wkx3mGavJ0HiOQWd34MOyA3EROOkx97AolsIE0x-HE6OEcYyPsBscvBt2RFvkNEsoY5IQmOfMUpmyEDyQefELLqRzJtkdxOGWy3L4pnDoaE5w_3WfHj08e79efy-tvmar26Lq3QYiqFbJS20Nim6aSWrVK1zoITohLYWIlN1VpuW8lbYRlFEAq6TiN3AmTLOT8rrhZuF-De7KPfQfxjAnjzTwixNxBzmQMaS7muFO9aVFzUIMABoGuUU1JbpHVmvVtY-7ndYWdzZyIMj6CPI6Pfmj78NiwPhnGmM-HigRDDrzm30dyHOeZWJlNpSjmnlT78c7m4eshl-dGFTLP5dHkuNozofNZXStJKSqaanPB6SbAxpBTRHWti1Bx2wxx3I3tfLd6fEHuMR-cxfPHf8M2XzeIw-87xv8FTv48</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2900330295</pqid></control><display><type>article</type><title>Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Karger Open Access</source><creator>Silva, Maria Azevedo ; Leal, Carina ; Ruge, André ; Fernandes, Alexandra ; Cunha, Maria Fernanda ; Vasconcelos, Helena</creator><creatorcontrib>Silva, Maria Azevedo ; Leal, Carina ; Ruge, André ; Fernandes, Alexandra ; Cunha, Maria Fernanda ; Vasconcelos, Helena</creatorcontrib><description>Abstract
Introduction: Gastric metastases are quite infrequent. When arising from testicular germ cell tumors, gastric metastases are usually associated with nonseminomas. Case Report: A 45-year-old man presented with upper gastrointestinal bleeding, severe anemia, and elevated lactate dehydrogenase. Endoscopy revealed three atypical-looking gastric ulcers. Abdominal computed tomography showed an extensive heterogeneous retroperitoneal mass and a smaller one in the pelvis. Biopsies of both the ulcers and the retroperitoneal mass revealed a highly proliferative neoplasia of unknown origin. While the diagnostic work up was taking place, the patient complained of a testicular mass which was resected, after suspicious findings in the ultrasound. Histopathologic findings revealed a testicular seminoma. Revision of previous biopsies was compatible with metastatic seminoma to the stomach and the retroperitoneum. Discussion/Conclusion: Gastric metastasis arising from testicular seminoma is quite infrequent and usually diagnosed after the primary tumor is known. We report a rare case of a testicular seminoma presenting as upper gastrointestinal bleeding due to gastric metastases. This case highlights the importance of detailed anamnesis and physical examination in the differential diagnosis of atypical gastric ulcers with initial inconclusive work up and emphasizes an unusual manifestation of a germ cell malignancy.</description><identifier>ISSN: 2341-4545</identifier><identifier>EISSN: 2387-1954</identifier><identifier>DOI: 10.1159/000526427</identifier><identifier>PMID: 37767307</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Anemia ; Antigens ; Biopsy ; Care and treatment ; Case reports ; Clinical Case Study ; Conflicts of interest ; Dehydrogenases ; Diagnosis ; Endoscopy ; gastric metastases ; gastrointestinal bleeding ; Hypotheses ; Lymphoma ; Medical prognosis ; Metastasis ; Stomach ; Stomach cancer ; Testicular cancer ; testicular seminoma ; Tomography ; Tumors ; Ulcers ; Ultrasonic imaging</subject><ispartof>GE Portuguese journal of gastroenterology, 2023-08, Vol.30 (4), p.311-315</ispartof><rights>2022 The Author(s). Published by S. Karger AG, Basel</rights><rights>COPYRIGHT 2023 S. Karger AG</rights><rights>2022 The Author(s). Published by S. Karger AG, Basel . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><rights>Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c494t-46879ca8c88d696b775979cf4424e8c6e82bc3cb63b4c10ea47add9e3f4a6b333</cites><orcidid>0000-0001-5772-5844 ; 0000-0001-9030-0645 ; 0000-0002-5545-868X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521319/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10521319/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,27614,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Silva, Maria Azevedo</creatorcontrib><creatorcontrib>Leal, Carina</creatorcontrib><creatorcontrib>Ruge, André</creatorcontrib><creatorcontrib>Fernandes, Alexandra</creatorcontrib><creatorcontrib>Cunha, Maria Fernanda</creatorcontrib><creatorcontrib>Vasconcelos, Helena</creatorcontrib><title>Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach</title><title>GE Portuguese journal of gastroenterology</title><addtitle>GE Port J Gastroenterol</addtitle><description>Abstract
Introduction: Gastric metastases are quite infrequent. When arising from testicular germ cell tumors, gastric metastases are usually associated with nonseminomas. Case Report: A 45-year-old man presented with upper gastrointestinal bleeding, severe anemia, and elevated lactate dehydrogenase. Endoscopy revealed three atypical-looking gastric ulcers. Abdominal computed tomography showed an extensive heterogeneous retroperitoneal mass and a smaller one in the pelvis. Biopsies of both the ulcers and the retroperitoneal mass revealed a highly proliferative neoplasia of unknown origin. While the diagnostic work up was taking place, the patient complained of a testicular mass which was resected, after suspicious findings in the ultrasound. Histopathologic findings revealed a testicular seminoma. Revision of previous biopsies was compatible with metastatic seminoma to the stomach and the retroperitoneum. Discussion/Conclusion: Gastric metastasis arising from testicular seminoma is quite infrequent and usually diagnosed after the primary tumor is known. We report a rare case of a testicular seminoma presenting as upper gastrointestinal bleeding due to gastric metastases. This case highlights the importance of detailed anamnesis and physical examination in the differential diagnosis of atypical gastric ulcers with initial inconclusive work up and emphasizes an unusual manifestation of a germ cell malignancy.</description><subject>Anemia</subject><subject>Antigens</subject><subject>Biopsy</subject><subject>Care and treatment</subject><subject>Case reports</subject><subject>Clinical Case Study</subject><subject>Conflicts of interest</subject><subject>Dehydrogenases</subject><subject>Diagnosis</subject><subject>Endoscopy</subject><subject>gastric metastases</subject><subject>gastrointestinal bleeding</subject><subject>Hypotheses</subject><subject>Lymphoma</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Stomach</subject><subject>Stomach cancer</subject><subject>Testicular cancer</subject><subject>testicular seminoma</subject><subject>Tomography</subject><subject>Tumors</subject><subject>Ulcers</subject><subject>Ultrasonic imaging</subject><issn>2341-4545</issn><issn>2387-1954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkkFv1DAQhSMEolXpgTsHSz1xSLFjx465oGWBpaiIipazNXHGWZdsvNgJEv8eL6lWqoR8sPXmzefRzBTFS0YvGav1G0ppXUlRqSfFacUbVTJdi6eHt2ClqEV9Upyn5FtaU8VlI6vnxQlXSipO1Wkx3mGavJ0HiOQWd34MOyA3EROOkx97AolsIE0x-HE6OEcYyPsBscvBt2RFvkNEsoY5IQmOfMUpmyEDyQefELLqRzJtkdxOGWy3L4pnDoaE5w_3WfHj08e79efy-tvmar26Lq3QYiqFbJS20Nim6aSWrVK1zoITohLYWIlN1VpuW8lbYRlFEAq6TiN3AmTLOT8rrhZuF-De7KPfQfxjAnjzTwixNxBzmQMaS7muFO9aVFzUIMABoGuUU1JbpHVmvVtY-7ndYWdzZyIMj6CPI6Pfmj78NiwPhnGmM-HigRDDrzm30dyHOeZWJlNpSjmnlT78c7m4eshl-dGFTLP5dHkuNozofNZXStJKSqaanPB6SbAxpBTRHWti1Bx2wxx3I3tfLd6fEHuMR-cxfPHf8M2XzeIw-87xv8FTv48</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Silva, Maria Azevedo</creator><creator>Leal, Carina</creator><creator>Ruge, André</creator><creator>Fernandes, Alexandra</creator><creator>Cunha, Maria Fernanda</creator><creator>Vasconcelos, Helena</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5772-5844</orcidid><orcidid>https://orcid.org/0000-0001-9030-0645</orcidid><orcidid>https://orcid.org/0000-0002-5545-868X</orcidid></search><sort><creationdate>20230801</creationdate><title>Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach</title><author>Silva, Maria Azevedo ; Leal, Carina ; Ruge, André ; Fernandes, Alexandra ; Cunha, Maria Fernanda ; Vasconcelos, Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-46879ca8c88d696b775979cf4424e8c6e82bc3cb63b4c10ea47add9e3f4a6b333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anemia</topic><topic>Antigens</topic><topic>Biopsy</topic><topic>Care and treatment</topic><topic>Case reports</topic><topic>Clinical Case Study</topic><topic>Conflicts of interest</topic><topic>Dehydrogenases</topic><topic>Diagnosis</topic><topic>Endoscopy</topic><topic>gastric metastases</topic><topic>gastrointestinal bleeding</topic><topic>Hypotheses</topic><topic>Lymphoma</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Stomach</topic><topic>Stomach cancer</topic><topic>Testicular cancer</topic><topic>testicular seminoma</topic><topic>Tomography</topic><topic>Tumors</topic><topic>Ulcers</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Maria Azevedo</creatorcontrib><creatorcontrib>Leal, Carina</creatorcontrib><creatorcontrib>Ruge, André</creatorcontrib><creatorcontrib>Fernandes, Alexandra</creatorcontrib><creatorcontrib>Cunha, Maria Fernanda</creatorcontrib><creatorcontrib>Vasconcelos, Helena</creatorcontrib><collection>Karger Open Access</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>GE Portuguese journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Maria Azevedo</au><au>Leal, Carina</au><au>Ruge, André</au><au>Fernandes, Alexandra</au><au>Cunha, Maria Fernanda</au><au>Vasconcelos, Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach</atitle><jtitle>GE Portuguese journal of gastroenterology</jtitle><addtitle>GE Port J Gastroenterol</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>30</volume><issue>4</issue><spage>311</spage><epage>315</epage><pages>311-315</pages><issn>2341-4545</issn><eissn>2387-1954</eissn><abstract>Abstract
Introduction: Gastric metastases are quite infrequent. When arising from testicular germ cell tumors, gastric metastases are usually associated with nonseminomas. Case Report: A 45-year-old man presented with upper gastrointestinal bleeding, severe anemia, and elevated lactate dehydrogenase. Endoscopy revealed three atypical-looking gastric ulcers. Abdominal computed tomography showed an extensive heterogeneous retroperitoneal mass and a smaller one in the pelvis. Biopsies of both the ulcers and the retroperitoneal mass revealed a highly proliferative neoplasia of unknown origin. While the diagnostic work up was taking place, the patient complained of a testicular mass which was resected, after suspicious findings in the ultrasound. Histopathologic findings revealed a testicular seminoma. Revision of previous biopsies was compatible with metastatic seminoma to the stomach and the retroperitoneum. Discussion/Conclusion: Gastric metastasis arising from testicular seminoma is quite infrequent and usually diagnosed after the primary tumor is known. We report a rare case of a testicular seminoma presenting as upper gastrointestinal bleeding due to gastric metastases. This case highlights the importance of detailed anamnesis and physical examination in the differential diagnosis of atypical gastric ulcers with initial inconclusive work up and emphasizes an unusual manifestation of a germ cell malignancy.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>37767307</pmid><doi>10.1159/000526427</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-5772-5844</orcidid><orcidid>https://orcid.org/0000-0001-9030-0645</orcidid><orcidid>https://orcid.org/0000-0002-5545-868X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2341-4545 |
| ispartof | GE Portuguese journal of gastroenterology, 2023-08, Vol.30 (4), p.311-315 |
| issn | 2341-4545 2387-1954 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10521319 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Karger Open Access |
| subjects | Anemia Antigens Biopsy Care and treatment Case reports Clinical Case Study Conflicts of interest Dehydrogenases Diagnosis Endoscopy gastric metastases gastrointestinal bleeding Hypotheses Lymphoma Medical prognosis Metastasis Stomach Stomach cancer Testicular cancer testicular seminoma Tomography Tumors Ulcers Ultrasonic imaging |
| title | Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T02%3A01%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Testicular%20Seminoma%20Presenting%20as%20Gastrointestinal%20Bleeding:%20A%20Rare%20Cause%20of%20Metastatic%20Disease%20in%20the%20Stomach&rft.jtitle=GE%20Portuguese%20journal%20of%20gastroenterology&rft.au=Silva,%20Maria%20Azevedo&rft.date=2023-08-01&rft.volume=30&rft.issue=4&rft.spage=311&rft.epage=315&rft.pages=311-315&rft.issn=2341-4545&rft.eissn=2387-1954&rft_id=info:doi/10.1159/000526427&rft_dat=%3Cgale_pubme%3EA760266178%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2900330295&rft_id=info:pmid/37767307&rft_galeid=A760266178&rft_doaj_id=oai_doaj_org_article_c039273dbe7345a4afaaef87f769ce05&rfr_iscdi=true |