Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4: ANG1-CPA4 axis promotes TNBC progression

Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4: ANG1-CPA4 axis promotes TNBC progression

Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta biochimica et biophysica Sinica 2023-05, Vol.55 (9), p.1487-1495
Hauptverfasser: Liu, Xue, Liang, Huichun, Fang, Huan, Xiao, Ji, Yang, Chuanyu, Zhou, Zhongmei, Feng, Jing, Chen, Ceshi
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1495
container_issue 9
container_start_page 1487
container_title Acta biochimica et biophysica Sinica
container_volume 55
creator Liu, Xue
Liang, Huichun
Fang, Huan
Xiao, Ji
Yang, Chuanyu
Zhou, Zhongmei
Feng, Jing
Chen, Ceshi
description Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of ANG1 inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.
doi_str_mv 10.3724/abbs.2023082
format Article
fullrecord <record><control><sourceid>pubmedcentral</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10520468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_10520468</sourcerecordid><originalsourceid>FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_105204683</originalsourceid><addsrcrecordid>eNqljMtOAyEYhYmxsfWy8wF4gancBurKNEbTB3BPYPqXYhggwDTO2zsmbly7Oufk-3IQeqRkyxUTT8baumWEcbJjV2hDleg7xRS5XrpUrHumol-j21o_CeFSUnKD1lxRyZgUGxT20fmUk4fmY0dxLmlMDSpuxecAXQRnmr8AtgVMbXgwcYCCBwjhxw3-BGURUsR2xlMu4Kaw7OgWs9j0NWfIzR9NBbwX92h1MqHCw2_eoZf3t4_XQ5cnO8JxgNiKCToXP5oy62S8_kuiP2uXLpqSnhEhd_z_D9-BF2nM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4: ANG1-CPA4 axis promotes TNBC progression</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Liu, Xue ; Liang, Huichun ; Fang, Huan ; Xiao, Ji ; Yang, Chuanyu ; Zhou, Zhongmei ; Feng, Jing ; Chen, Ceshi</creator><creatorcontrib>Liu, Xue ; Liang, Huichun ; Fang, Huan ; Xiao, Ji ; Yang, Chuanyu ; Zhou, Zhongmei ; Feng, Jing ; Chen, Ceshi</creatorcontrib><description>Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of ANG1 inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.</description><identifier>ISSN: 1672-9145</identifier><identifier>EISSN: 1745-7270</identifier><identifier>DOI: 10.3724/abbs.2023082</identifier><identifier>PMID: 37162264</identifier><language>eng</language><publisher>Oxford University Press</publisher><ispartof>Acta biochimica et biophysica Sinica, 2023-05, Vol.55 (9), p.1487-1495</ispartof><rights>The Author(s) 2021. 2023 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520468/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520468/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Liu, Xue</creatorcontrib><creatorcontrib>Liang, Huichun</creatorcontrib><creatorcontrib>Fang, Huan</creatorcontrib><creatorcontrib>Xiao, Ji</creatorcontrib><creatorcontrib>Yang, Chuanyu</creatorcontrib><creatorcontrib>Zhou, Zhongmei</creatorcontrib><creatorcontrib>Feng, Jing</creatorcontrib><creatorcontrib>Chen, Ceshi</creatorcontrib><title>Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4: ANG1-CPA4 axis promotes TNBC progression</title><title>Acta biochimica et biophysica Sinica</title><description>Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of ANG1 inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.</description><issn>1672-9145</issn><issn>1745-7270</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqljMtOAyEYhYmxsfWy8wF4gancBurKNEbTB3BPYPqXYhggwDTO2zsmbly7Oufk-3IQeqRkyxUTT8baumWEcbJjV2hDleg7xRS5XrpUrHumol-j21o_CeFSUnKD1lxRyZgUGxT20fmUk4fmY0dxLmlMDSpuxecAXQRnmr8AtgVMbXgwcYCCBwjhxw3-BGURUsR2xlMu4Kaw7OgWs9j0NWfIzR9NBbwX92h1MqHCw2_eoZf3t4_XQ5cnO8JxgNiKCToXP5oy62S8_kuiP2uXLpqSnhEhd_z_D9-BF2nM</recordid><startdate>20230509</startdate><enddate>20230509</enddate><creator>Liu, Xue</creator><creator>Liang, Huichun</creator><creator>Fang, Huan</creator><creator>Xiao, Ji</creator><creator>Yang, Chuanyu</creator><creator>Zhou, Zhongmei</creator><creator>Feng, Jing</creator><creator>Chen, Ceshi</creator><general>Oxford University Press</general><scope>5PM</scope></search><sort><creationdate>20230509</creationdate><title>Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4</title><author>Liu, Xue ; Liang, Huichun ; Fang, Huan ; Xiao, Ji ; Yang, Chuanyu ; Zhou, Zhongmei ; Feng, Jing ; Chen, Ceshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_105204683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xue</creatorcontrib><creatorcontrib>Liang, Huichun</creatorcontrib><creatorcontrib>Fang, Huan</creatorcontrib><creatorcontrib>Xiao, Ji</creatorcontrib><creatorcontrib>Yang, Chuanyu</creatorcontrib><creatorcontrib>Zhou, Zhongmei</creatorcontrib><creatorcontrib>Feng, Jing</creatorcontrib><creatorcontrib>Chen, Ceshi</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta biochimica et biophysica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xue</au><au>Liang, Huichun</au><au>Fang, Huan</au><au>Xiao, Ji</au><au>Yang, Chuanyu</au><au>Zhou, Zhongmei</au><au>Feng, Jing</au><au>Chen, Ceshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4: ANG1-CPA4 axis promotes TNBC progression</atitle><jtitle>Acta biochimica et biophysica Sinica</jtitle><date>2023-05-09</date><risdate>2023</risdate><volume>55</volume><issue>9</issue><spage>1487</spage><epage>1495</epage><pages>1487-1495</pages><issn>1672-9145</issn><eissn>1745-7270</eissn><abstract>Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of ANG1 inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.</abstract><pub>Oxford University Press</pub><pmid>37162264</pmid><doi>10.3724/abbs.2023082</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1672-9145
ispartof Acta biochimica et biophysica Sinica, 2023-05, Vol.55 (9), p.1487-1495
issn 1672-9145
1745-7270
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10520468
source DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
title Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4: ANG1-CPA4 axis promotes TNBC progression
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T00%3A16%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Angiopoietin-1%20promotes%20triple-negative%20breast%20cancer%20cell%20proliferation%20by%20upregulating%20carboxypeptidase%20A4:%20ANG1-CPA4%20axis%20promotes%20TNBC%20progression&rft.jtitle=Acta%20biochimica%20et%20biophysica%20Sinica&rft.au=Liu,%20Xue&rft.date=2023-05-09&rft.volume=55&rft.issue=9&rft.spage=1487&rft.epage=1495&rft.pages=1487-1495&rft.issn=1672-9145&rft.eissn=1745-7270&rft_id=info:doi/10.3724/abbs.2023082&rft_dat=%3Cpubmedcentral%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_10520468%3C/pubmedcentral%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/37162264&rfr_iscdi=true