Osteoclast-derived apoptotic bodies inhibit naive CD8 + T cell activation via Siglec15, promoting breast cancer secondary metastasis

The bone microenvironment promotes cancer cell proliferation and dissemination. During periodic bone remodeling, osteoclasts undergo apoptosis, producing large numbers of apoptotic bodies (ABs). However, the biological role of osteoclast-derived ABs, which are residents of the bone-tumor niche, rema...

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Veröffentlicht in:	Cell reports. Medicine 2023-09, Vol.4 (9), p.101165-101165, Article 101165
Hauptverfasser:	Wu, Yutong, Ai, Hongbo, Xi, Yuhang, Tan, Jiulin, Qu, Ying, Xu, Jianzhong, Luo, Fei, Dou, Ce
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes Extracellular Vesicles Melanoma Melanoma, Cutaneous Malignant Mice Mice, Inbred MRL lpr Osteoclasts Tumor Microenvironment
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