The dangerous link between coal dust exposure and DNA damage: unraveling the role of some of the chemical agents and oxidative stress
Exposure to coal mining dust poses a substantial health hazard to individuals due to the complex mixture of components released during the extraction process. This study aimed to assess the oxidative potential of residual coal mining dust on human lymphocyte DNA and telomeres and to perform a chemic...
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| Veröffentlicht in: | Environmental geochemistry and health 2023-10, Vol.45 (10), p.7081-7097 |
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| creator | Miranda-Guevara, Alvaro Muñoz-Acevedo, Amner Fiorillo-Moreno, Ornella Acosta-Hoyos, Antonio Pacheco-Londoño, Leonardo Quintana-Sosa, Milton De Moya, Yurina Dias, Johnny de Souza, Guilherme Soares Martinez-Lopez, Wilner Garcia, Ana Letícia Hilário da Silva, Juliana Borges, Malu Siqueira Henriques, João Antonio Pêgas León-Mejía, Grethel |
| description | Exposure to coal mining dust poses a substantial health hazard to individuals due to the complex mixture of components released during the extraction process. This study aimed to assess the oxidative potential of residual coal mining dust on human lymphocyte DNA and telomeres and to perform a chemical characterization of coal dust and urine samples. The study included 150 individuals exposed to coal dust for over ten years, along with 120 control individuals. The results revealed significantly higher levels of DNA damage in the exposed group, as indicated by the standard comet assay, and oxidative damage, as determined by the FPG-modified comet assay. Moreover, the exposed individuals exhibited significantly shorter telomeres compared to the control group, and a significant correlation was found between telomere length and oxidative DNA damage. Using the PIXE method on urine samples, significantly higher concentrations of sodium (Na), phosphorus (P), sulfur (S), chlorine (Cl), potassium (K), iron (Fe), zinc (Zn), and bromine (Br) were observed in the exposed group compared to the control group. Furthermore, men showed shorter telomeres, greater DNA damage, and higher concentrations of nickel (Ni), calcium (Ca), and chromium (Cr) compared to exposed women. Additionally, the study characterized the particles released into the environment through GC–MS analysis, identifying several compounds, including polycyclic aromatic hydrocarbons (PAHs) such as fluoranthene, naphthalene, anthracene, 7H-benzo[c]fluorene, phenanthrene, pyrene, benz[a]anthracene, chrysene, and some alkyl derivatives. These findings underscore the significant health risks associated with exposure to coal mining dust, emphasizing the importance of further research and the implementation of regulatory measures to safeguard the health of individuals in affected populations.
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| doi_str_mv | 10.1007/s10653-023-01697-3 |
| format | Article |
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The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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This study aimed to assess the oxidative potential of residual coal mining dust on human lymphocyte DNA and telomeres and to perform a chemical characterization of coal dust and urine samples. The study included 150 individuals exposed to coal dust for over ten years, along with 120 control individuals. The results revealed significantly higher levels of DNA damage in the exposed group, as indicated by the standard comet assay, and oxidative damage, as determined by the FPG-modified comet assay. Moreover, the exposed individuals exhibited significantly shorter telomeres compared to the control group, and a significant correlation was found between telomere length and oxidative DNA damage. Using the PIXE method on urine samples, significantly higher concentrations of sodium (Na), phosphorus (P), sulfur (S), chlorine (Cl), potassium (K), iron (Fe), zinc (Zn), and bromine (Br) were observed in the exposed group compared to the control group. Furthermore, men showed shorter telomeres, greater DNA damage, and higher concentrations of nickel (Ni), calcium (Ca), and chromium (Cr) compared to exposed women. Additionally, the study characterized the particles released into the environment through GC–MS analysis, identifying several compounds, including polycyclic aromatic hydrocarbons (PAHs) such as fluoranthene, naphthalene, anthracene, 7H-benzo[c]fluorene, phenanthrene, pyrene, benz[a]anthracene, chrysene, and some alkyl derivatives. These findings underscore the significant health risks associated with exposure to coal mining dust, emphasizing the importance of further research and the implementation of regulatory measures to safeguard the health of individuals in affected populations.
Graphic abstract</description><subject>Anthracene</subject><subject>anthracenes</subject><subject>Aromatic compounds</subject><subject>Aromatic hydrocarbons</subject><subject>Atmospheric particulates</subject><subject>Bioassays</subject><subject>Bromine</subject><subject>Calcium</subject><subject>Chemical agents</subject><subject>Chlorine</subject><subject>Chromium</subject><subject>Chrysene</subject><subject>Coal</subject><subject>Coal dust</subject><subject>Coal mining</subject><subject>Comet assay</subject><subject>Damage detection</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Dust</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Exposure</subject><subject>Fluoranthene</subject><subject>Fluorene</subject><subject>fluorenes</subject><subject>Geochemistry</subject><subject>Health hazards</subject><subject>Health risks</subject><subject>humans</subject><subject>Iron</subject><subject>Lymphocytes</subject><subject>Men</subject><subject>Naphthalene</subject><subject>Nickel</subject><subject>Original Paper</subject><subject>Oxidative stress</subject><subject>Phenanthrene</subject><subject>phenanthrenes</subject><subject>Phosphorus</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Potassium</subject><subject>Public Health</subject><subject>Sodium</subject><subject>Soil Science & Conservation</subject><subject>Sulfur</subject><subject>Sulphur</subject><subject>Telomerase</subject><subject>Telomeres</subject><subject>Terrestrial Pollution</subject><subject>Toxicity 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of the chemical agents and oxidative stress</atitle><jtitle>Environmental geochemistry and health</jtitle><stitle>Environ Geochem Health</stitle><addtitle>Environ Geochem Health</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>45</volume><issue>10</issue><spage>7081</spage><epage>7097</epage><pages>7081-7097</pages><issn>0269-4042</issn><eissn>1573-2983</eissn><abstract>Exposure to coal mining dust poses a substantial health hazard to individuals due to the complex mixture of components released during the extraction process. This study aimed to assess the oxidative potential of residual coal mining dust on human lymphocyte DNA and telomeres and to perform a chemical characterization of coal dust and urine samples. The study included 150 individuals exposed to coal dust for over ten years, along with 120 control individuals. The results revealed significantly higher levels of DNA damage in the exposed group, as indicated by the standard comet assay, and oxidative damage, as determined by the FPG-modified comet assay. Moreover, the exposed individuals exhibited significantly shorter telomeres compared to the control group, and a significant correlation was found between telomere length and oxidative DNA damage. Using the PIXE method on urine samples, significantly higher concentrations of sodium (Na), phosphorus (P), sulfur (S), chlorine (Cl), potassium (K), iron (Fe), zinc (Zn), and bromine (Br) were observed in the exposed group compared to the control group. Furthermore, men showed shorter telomeres, greater DNA damage, and higher concentrations of nickel (Ni), calcium (Ca), and chromium (Cr) compared to exposed women. Additionally, the study characterized the particles released into the environment through GC–MS analysis, identifying several compounds, including polycyclic aromatic hydrocarbons (PAHs) such as fluoranthene, naphthalene, anthracene, 7H-benzo[c]fluorene, phenanthrene, pyrene, benz[a]anthracene, chrysene, and some alkyl derivatives. These findings underscore the significant health risks associated with exposure to coal mining dust, emphasizing the importance of further research and the implementation of regulatory measures to safeguard the health of individuals in affected populations.
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| fulltext | fulltext |
| identifier | ISSN: 0269-4042 |
| ispartof | Environmental geochemistry and health, 2023-10, Vol.45 (10), p.7081-7097 |
| issn | 0269-4042 1573-2983 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10517898 |
| source | SpringerLink Journals (MCLS) |
| subjects | Anthracene anthracenes Aromatic compounds Aromatic hydrocarbons Atmospheric particulates Bioassays Bromine Calcium Chemical agents Chlorine Chromium Chrysene Coal Coal dust Coal mining Comet assay Damage detection Deoxyribonucleic acid DNA DNA damage Dust Earth and Environmental Science Environment Environmental Chemistry Environmental Health Exposure Fluoranthene Fluorene fluorenes Geochemistry Health hazards Health risks humans Iron Lymphocytes Men Naphthalene Nickel Original Paper Oxidative stress Phenanthrene phenanthrenes Phosphorus Polycyclic aromatic hydrocarbons Potassium Public Health Sodium Soil Science & Conservation Sulfur Sulphur Telomerase Telomeres Terrestrial Pollution Toxicity tests urine Women Zinc |
| title | The dangerous link between coal dust exposure and DNA damage: unraveling the role of some of the chemical agents and oxidative stress |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T00%3A58%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20dangerous%20link%20between%20coal%20dust%20exposure%20and%20DNA%20damage:%20unraveling%20the%20role%20of%20some%20of%20the%20chemical%20agents%20and%20oxidative%20stress&rft.jtitle=Environmental%20geochemistry%20and%20health&rft.au=Miranda-Guevara,%20Alvaro&rft.date=2023-10-01&rft.volume=45&rft.issue=10&rft.spage=7081&rft.epage=7097&rft.pages=7081-7097&rft.issn=0269-4042&rft.eissn=1573-2983&rft_id=info:doi/10.1007/s10653-023-01697-3&rft_dat=%3Cproquest_pubme%3E3153151415%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2867645107&rft_id=info:pmid/37542205&rfr_iscdi=true |