Structure of the hepatitis C virus E1E2 glycoprotein complex

Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma in humans and afflicts more than 58 million people worldwide. The HCV envelope E1 and E2 glycoproteins are essential for viral entry and comprise the primary antigenic target for ne...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2022-10, Vol.378 (6617), p.263-269
Hauptverfasser:	Torrents de la Peña, Alba, Sliepen, Kwinten, Eshun-Wilson, Lisa, Newby, Maddy L, Allen, Joel D, Zon, Ian, Koekkoek, Sylvie, Chumbe, Ana, Crispin, Max, Schinkel, Janke, Lander, Gabriel C, Sanders, Rogier W, Ward, Andrew B
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antiviral Agents - chemistry Broadly Neutralizing Antibodies Cancer vaccines Chronic infection Cirrhosis Cryoelectron Microscopy Drug development Electron microscopy Epitopes Glycoproteins Hepacivirus - chemistry Hepacivirus - immunology Hepatitis Hepatitis C Hepatitis C - virology Humans Liver Liver cancer Liver cirrhosis Neutralizing Protein Multimerization Torrents Vaccine development Vaccines Viral Envelope Proteins - chemistry Viral Envelope Proteins - immunology Viral Hepatitis Vaccines - chemistry Viral Hepatitis Vaccines - immunology Viruses
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