Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function

Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid derivatives were identified as DFMO adjunct agents....

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Veröffentlicht in:	Journal of medicinal chemistry 2022-11, Vol.65 (22), p.15391-15415
Hauptverfasser:	Dobrovolskaite, Aiste, Moots, Holly, Tantak, Mukund P., Shah, Kunal, Thomas, Jenna, Dinara, Sharifa, Massaro, Chelsea, Hershberger, Paul M., Maloney, Patrick R., Peddibhotla, Satyamaheshwar, Sugarman, Eliot, Litherland, Sally, Arnoletti, Juan Pablo, Jha, Rajiv Kumar, Levens, David, Phanstiel, Otto
Format:	Artikel
Sprache:	eng
Schlagworte:	Eflornithine - pharmacology RNA, Messenger - genetics RNA-Binding Proteins Spermidine - metabolism
Online-Zugang:	Volltext
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